E. lemming is the 2010 iGEM project of ETH Zurich. We intend to control movement of a single E. coli bacterium by hijacking chemotaxis. Position and direction of the bacterium is monitored by image processing algorithms, which are linked to a controller device. Find out more about our motivation and project idea!
We created a short animation about the project idea and general concept of E. lemming. Find out, how we combine biology and information processing to create E. lemming.
By coupling proteins of the chemotaxis pathway to a light-sensitive spatial localization system, the chemotactic activity can be controlled reversibly. To find out more about our project on the molecular level biological implementation visit this section.
Mathematical modeling supports analysis of biological systems since the advent of synthetic biology. Find out, how this not only supported wet laboratory experiments by providing time and effort alleviating network structure and experimental design selection, but also provided a test bench for the information processing part.
Implementation of a comprehensive information processing workflow for controlling E. lemming was achieved by combination of microscopy, image processing, cell detection and a controller. Find out more about how this not only created E. lemming but also created a new application for synthetic biology: Gaming!
We created for E. lemming a BioBrick and a Matlab Toolkit. Find out, how this tools can be used for similar projects and learn more about our comprehensive systems design and systems implementation approaches, which were necessary for the success of E. lemming.
Find out who created E. lemming and learn about the different backgrounds of the people who tried to achieve one common goal: Having a great experience and going crazy with E. lemming!
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