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User:MayaBrandi/1 July 2010
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Revision as of 15:15, 1 July 2010 by Mayabrandi (Talk | contribs)
1 Microarrays - reliability
- How reliable is the protein regulation profile in the article "Transcriptional profiling of melanocytes..."
2 How should one priorate different types of protein-protein interactions?
Focus on experimental (not predictive ) data and focus first of all at physical PPI second at co expression and co localisation. Skip the rest.
To improve PPI reliability
* Find a good coverage from many primary databases. -How many and with?
* What experiments were used? If the same result is dereved from many different experiments then the PPI is more reliable.
* Look at 3D structures...?
Compare with canonical pathways to get a better insight in the functional roles of the proteins in the network.
