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Team:Northwestern/Project/Apoptosis
From 2010.igem.org
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We used the Apoptosis Cassette by Brown '08 iGEM team (K124017).
The bacteriophage cassette includes S105 protein (Holin), R protein (Endolysin), and Rz protein, all of which act in combination to lyse the bacteria.
Holin is a small membrane protein that produces holes in the membrane.
R is an endolysin that digests and cleaves the cell wall.
Rz protein, a periplasmic protein, through reasons that are not yet totally clear, carries out the final step of host lysis.
