Team:Groningen/Modeling

From 2010.igem.org

The modelling time is developing a mathematical model which describes the growth of biofilms. Furthermore we are researching how strong the biofilm is, how fast it grows and other parameters needed fot the model.

In the literature we found models that described biofilms in by a so called differential discrete cellular automaton approach. This means that we are using both discrete and continous models to determine what is happening in our biofim.

The approach we are taking now is mainly based on the articles below:

Picioreanu C, van Loosdrecht MC, Heijnen JJ. A new combined differential-discrete cellular automaton approach for biofilm modeling: application for growth in gel beads, Biotechnology Bioengineering 1998 Mar 20;57(6):718-31. http://www.ncbi.nlm.nih.gov/pubmed/10099251

Picioreanu C, van Loosdrecht MC, Heijnen JJ. Mathematical modeling of biofilm structure with a hybrid differential-discrete cellular automaton approach, Biotechnology Bioengineering 1998 Apr 5;58(1):101-16. http://www.ncbi.nlm.nih.gov/pubmed/10099266

van Loosdrecht MC, Heijnen JJ, Eberl H, Kreft J, Picioreanu C. Mathematical modelling of biofilm structures, Antonie Van Leeuwenhoek, 2002 Aug;81(1-4):245-56. http://www.ncbi.nlm.nih.gov/pubmed/12448723

A useful article on biofilms in general is: López D, Vlamakis H, Kolter R. Biofilms, Cold Spring Harb Perspect Biol. 2010 Jul 1;2(7):a000398. http://www.ncbi.nlm.nih.gov/pubmed/20519345