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From 2010.igem.org

Sensitivity analysis

For all beta parameters (lumped variables for transcriptions speed, translations speed, promoter strength and rbs strength) and all K parameters (equilibrium constant for binding of AlkS with alkanes and coefficients for the activity of promoters) a sensitivity analysis has been performed. This was done by varying the parameters from 50% of their original values to 200% of their original values.

For this range of parameter values it is checked how much the steady state concentration of AlkB is and how long it takes for 95% of the steady state concentration of AlkB to be reached from steady state values for no alkanes to steady state values for 1 µM of alkanes.

In the figures below are the results for this sensitivity analysis.

These results are summarized in table 1. A '0' means insensitive, a '+' means somewhat sensitive and a '++' is very sensitive.

Table 1; results for sensitivity analysis for the gene regulation model

Parameter	Sensitive for steady state concentration	Sensitive for reaching steady state concentration
βmaxS1	0	+
βmaxS2	+	+
βmaxB	++	0
βmaxAlkS	+	+
βmaxAlkB	++	0
KHC	+	+
KS1	0	+
KS2	+	+
KB	+	+

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