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Team:Cambridge/turingpatterns
From 2010.igem.org
Investigating the idea of Turing patterns in cell colonies: Hannah + Paul
Research of the previous Team's work
iGEM Mexico 2007
- Project Failed
- Admitted were underfunded, no results shown
iGEM Mexico 2009
- Apparently 11 out of 12 ligations were successful - they would have been able to test the system had the final ligation occurred.
- The only experimental results were those demonstrating that AHL was initiating it's own transcription via the expression of GFP.
- Seemed to have done quite a lot of good modelling work. So will be difficult to go much further on this aspect of the project
iGEM 2008 Cambridge team - iBrain
- Planned to use similar quorum sensing mechanisms with the lux operon to detect activity. However, the lux operon would not work in a gram positive organism such as Bacillus therefore only E.coli could work.
Papers on Turing patterns
- Original paper from Alan Turing: http://www.dna.caltech.edu/courses/cs191/paperscs191/turing.pdf
Conclusion
- Turing patterns have been well described theoretically
- Mexico 2009 modelled the problem extensively
- Our project WILL have to reach the implementation stage to go a step further
- Some Biobricks exist. A lot of the project will have to do with fine tuning of the system
- Combine with one of the other projects? Bioluminescence?
