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Team:Aberdeen Scotland/Bifurcation
From 2010.igem.org
University of Aberdeen - ayeSwitch
Bifurcation Analysis
The literal meaning of bifurcation is, "division into two parts, branches or aspects" (Answers). In mathematics, this 'division' is reference to when non-linear equation suddenly switches from having one solution to having multiple solution when a parameter of the system is varied. The point at which bifurcation occurs is referred to as the 'bifurcation point.' If a system is bistable it can be stable, or at rest in two distinct states.
Figure 1.This is a graphical representation of bistability. Ball 2 ban be equally 'happy' in either the 'one' or 'three' positions. Once it falls into one of these states, ball 2 will not be inclined to leave this state, hence making it a "stable state."
Why are they important?
Analysing the stability of a system is a key to the success of a project. In biological terms, bistability represents the potential for out system to switch between the expression of green and cyan fluorescent proteins. Our goal is to analyse the parameter space in order to determine which parameters are needed to allow for bistability in the system.
a bifurcation diagram has branches which define the possible states a system can rest in. By analysing the bifurcation plots, we can determine how far apart the two "branches," or stable states, are. The further apart the branches, the harder it will be to attain a switch between the two stable states, however the switch also becomes more stable with increased distance between the branches. THerefore, we want to manipulate the parameters in the system to guarantee stable bistability.
How do you analyse the stability of a system?
In order to analyse the stability of the system, we utilised XPP Auto, C programming, and MATLAB. we will attempt to detail the math behind what the programme does computationally. The process involved with general stability analysis is as follows. We have takes a simple example system that is easy to analyse in order to demonstrate the general process:
Take the foloowing example system of two differential equations:
