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Team:ETHZ Basel/Modeling/Combined
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= Combined model = | = Combined model = | ||
[[Image:ETHZ_Basel_molecular.png|thumb|400px|'''Combined model.''' Coupled individual models for the simulation of the whole process and their interfaces. The concentration of CheYp determines the movement bias.]] | [[Image:ETHZ_Basel_molecular.png|thumb|400px|'''Combined model.''' Coupled individual models for the simulation of the whole process and their interfaces. The concentration of CheYp determines the movement bias.]] | ||
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| + | == Interface == | ||
| + | To combine light switch, chemotaxis and movement models, interfaces were defined. The combination was achieved in two steps: | ||
| + | |||
| + | * First, the deterministic light switch and chemotaxis models were combined by assuming a complete removal of a selected Che protein species by the light switch. The interface was defined as the concentration ([LSP-Che]) of this linked device. | ||
| + | |||
| + | * Second, the probabilistic movement model was combined with the light switch - chemotaxis model. To combine this models, the concentration of CheYp was used to be the input parameter of the movement model; determining the probability of straight run / tumbling. | ||
| + | |||
| + | [[Image:ETHZ_Basel_models_overview_comb.png|thumb|400px|'''Combined model.''' Coupled individual models for the simulation of the whole process and their interfaces.]] | ||
| + | |||
| + | == Challenges == | ||
| + | The combination of the deterministic and probabilistic models was the biggest challenge in combining the models. The problem of different step-size could be solved by combination via Simulink and independent numerical integration of the two model types. | ||
Revision as of 15:18, 2 October 2010
Combined model
Interface
To combine light switch, chemotaxis and movement models, interfaces were defined. The combination was achieved in two steps:
- First, the deterministic light switch and chemotaxis models were combined by assuming a complete removal of a selected Che protein species by the light switch. The interface was defined as the concentration ([LSP-Che]) of this linked device.
- Second, the probabilistic movement model was combined with the light switch - chemotaxis model. To combine this models, the concentration of CheYp was used to be the input parameter of the movement model; determining the probability of straight run / tumbling.
Challenges
The combination of the deterministic and probabilistic models was the biggest challenge in combining the models. The problem of different step-size could be solved by combination via Simulink and independent numerical integration of the two model types.
