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Team:St Andrews
From 2010.igem.org
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<li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors">Sponsors</a> | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors">Sponsors</a> | ||
<ul> | <ul> | ||
| + | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#Wellcome Trust">Wellcome Trust</a></li> | ||
| + | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#New England Biolabs">New England Biolabs</a></li> | ||
<li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#Fermentas">Fermentas</a></li> | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#Fermentas">Fermentas</a></li> | ||
<li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#GENEART">GENEART</a></li> | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#GENEART">GENEART</a></li> | ||
<li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#Mr Gene">Mr Gene</a></li> | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#Mr Gene">Mr Gene</a></li> | ||
| - | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors# | + | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#University of St Andrews">University of St Andrews</a></li> |
| - | + | ||
<li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#SULSA">SULSA</a></li> | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#SULSA">SULSA</a></li> | ||
| + | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#SALTIRE">SALTIRE</a></li> | ||
<li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#School of Biology">School of Biology</a></li> | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#School of Biology">School of Biology</a></li> | ||
<li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#School of Chemistry">School of Chemistry</a></li> | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#School of Chemistry">School of Chemistry</a></li> | ||
| - | |||
<li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#School of Physics and Astronomy">School of Physics and Astronomy</a></li> | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#School of Physics and Astronomy">School of Physics and Astronomy</a></li> | ||
| - | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors# | + | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#School of Computer Science">School of Computer Science</a></li> |
| - | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors# | + | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#B. Jannettas">B. Jannettas</a></li> |
| - | + | <li><a href="https://2010.igem.org/Team:St_Andrews/team/sponsors#flip!">flip!</a></li> | |
| - | </li> | + | </ul> |
| - | <li><a href="https://2010.igem.org/Team:St_Andrews/official">Official Team Profile</a></li> | + | </li><li><a href="https://2010.igem.org/Team:St_Andrews/official">Official Team Profile</a></li> |
</ul> | </ul> | ||
</li> | </li> | ||
Revision as of 16:57, 30 August 2010
Welcome to the University of St Andrew's iGEM wiki!
Our multidisciplinary group of scientists will first re-engineer the existing LuxR quorum sensing system to create a bistable switch. This will allow us to infer a signalling molecule concentration required to deactivate the system much lower than the concentration required to activate it.
The second part of the project involves introducing the cholera autoinducer synthase gene CqsA to Escherichia coli so that CAI-1 is secreted.
Our engineered Escherichia coli will harmlessly colonise the gut, and in large numbers secrete the cholera autoinducer, CAI-1. This will cause an immediate high autoinducer concentration to be detected by incoming Vibrio cholerae cells which then become avirulent and harmlessly pass out of the body.
The second part of the project involves introducing the cholera autoinducer synthase gene CqsA to Escherichia coli so that CAI-1 is secreted.
Our engineered Escherichia coli will harmlessly colonise the gut, and in large numbers secrete the cholera autoinducer, CAI-1. This will cause an immediate high autoinducer concentration to be detected by incoming Vibrio cholerae cells which then become avirulent and harmlessly pass out of the body.
