Team:ULB-Brussels/Safety

From 2010.igem.org

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     <td><strong>Would any of your project ideas raise safety issues in terms of:  
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     <td><p><strong>Would any of your project ideas raise safety issues in terms of:   researcher safety, <br>
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  researcher safety, <br>
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      public safety, or environmental safety? </strong></p></td>
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public safety, or  
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environmental safety? </strong></td>
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   <em>Since our project doesn’t include producing of  dangereous chemical products, or modification that could be pathogen, there is no evident safety issues, concerning public or the researcher himself, if we  except the well-known risks of all molecular biology researches.</em><br>
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   <em>Since our project doesn’t involve producing dangerous products, nor any  modification that could be pathogen, there is no evident issues concerning public or the researcher’s safety , except the well-known risks of all molecular biology researches.</em><br>
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   <em>Of course, any bacterial modification imply the risk of genetic transduction in other bacteria, which consequences we cannot predict; that’s why we have designed the very efficient way of preventing  contamination of the river by escaped bacteria (see <a href="https://2010.igem.org/Team:ULB-Brussels/QAModule">Cell Death module</a>)</em><br>
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   <em>Of course, any bacterial modification implies the risk of genetic transduction in other bacteria, which consequences we cannot predict; that’s why we have designed a way to prevent the bacteria from escapping. (see </em><em><a href="https://2010.igem.org/Team:ULB-Brussels/QAModule">Cell Death module</a></em><em>)</em><br>
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   <em>Environmentally speaking, the carbonated molecules  used by bacteria are obtained from wasted water, and residual carbone is found, at the end of the process, in the bacterial sludge, so the carbone balance is null. Even more, there is an free energy production,  through the release of dihydogen, which could be used as an alternative to other pollutive and limited resources. We can then affirm our project is  environmentally friendly, and doesn’t present evident environmental issues.</em><br>
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   <em>Environmentally speaking, the energy source used by bacteria is obtained from wastewaters, and residual carbone is found, at the end of the process, in the bacterial sludge, so the global carbone balance is null. Furthermore, the dihydrogen produced could be used as an alternative to other pollutive and limited energy sources. </em></p>
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     <td><strong>Do any of the new BioBrick parts (or devices) that you made this year <br>
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     <td><br>
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raise any safety issues? </strong></td>
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      <strong>Do any of the new BioBrick parts (or devices) that you made this year <br>
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        raise any safety issues? </strong></td>
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<p><em>No, all of the BioBricks we sent or intended to send were made from DNA parts usually used in our host lab, with no  particular safety issues.</em></p>
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  <em>No, all of the BioBricks we sent or intended to send were made from DNA parts usually used in our host lab, with no particular safety issues.</em><br>
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     <td><strong>Is there a local biosafety group, committee, or review board at your <br>
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     <td><br>
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institution? </strong></td>
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      <strong>Is there a local biosafety group, committee, or review board at your <br>
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        institution? </strong></td>
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<p><em>Yes, there is a biosafety committee specific of the ULB Institute of Molecular Biology and Medicine, which was our host lab.  This committee authorizes or refuses any new project to be carried in the institute, including end of studies works and thesis, which is routine, except if the project includes, for example, the manipulation of pathogenic organisms.</em><br>
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  <em>Yes, there is a specific biosafety commitee for the ULB Institute of Molecular Biology and Medicine, which was our host lab. They have to approve any new project carried in the institute, including end of studies works, and thesis, which is routine, except if the project includes, for example, manipulation of pathogens organisms.</em><br>
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   <em>See the </em><em><a href="https://2010.igem.org/Team:ULB-Brussels/ESIssues#_Toc275816602">Bioethics part, section biosecurity</a></em><em> for more detailed explanation about the standard protocol to follow in Belgium, in order to obtain the authorization to carry out a new experimentation.</em></p>
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   <em>See the <a href="https://2010.igem.org/Team:ULB-Brussels/ESIssues#_Toc275816602">Bioethics part, section biosecurity</a> for more detailed explanation about the standard protocol, in Belgium, to obtain the authorization to carry out an experimentation.</em><br>
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     <td><strong>If yes, what does your local biosafety group think about your project? </strong></td>
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     <td><br>
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      <strong>If yes, what does your local biosafety group think about your project? </strong></td>
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<p><br>
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<p><em>Since all the DNA parts we designed were already used, in different projects in our host lab, our project was considered  routine and was not subject to any specific decision of the committee. We didn’t have special presentations to do or forms to fill and obtained quite automatically the authorization to manipulate.</em></p>
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  <em>Our project was part of the routine of the committee,  since all the DNA parts we designed were already used, in different projects in our host lab. We didn’t have special presentations to do or forms to fill and obtained quite automatically the authorization to manipulate.</em><br>
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     <td><strong>If no, which specific biosafety rules or guidelines do you have to <br>
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consider in your country? <br>
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      <strong>If no, which specific biosafety rules or guidelines do you have to <br>
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Do you have any other ideas how to deal with safety issues that could <br>
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        consider in your country? <br>
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be useful for future iGEM competitions? How could parts, devices and <br>
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        Do you have any other ideas how to deal with safety issues that could <br>
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systems be made even safer through biosafety engineering?</strong></td>
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        be useful for future iGEM competitions? How could parts, devices and <br>
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        systems be made even safer through biosafety engineering?</strong></td>
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<p><br>
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<p><em>Perhaps potential pathogens or environmentally problematic parts should be referenced, with a dangerousness rate, based on a standard classification.</em><br>
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  <em>Maybe should potentially pathogens or environmentally problematic parts be referenced, with an indice of danger calculated using a  standard classification.</em><br>
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  <em>More drastically, having a standardized cell death system that could be  easily implemented in any cell or project presenting safety issues could be helpful.</em></p>
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<em>More drastically, for these devices presenting safety issues, we could impose the teams to encode it with a proposition of programmed cell death system, to avoid contamination, and they’ll have to prove the  efficacy of that security system before the DNA is sent to the other teams. </em></p>
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Latest revision as of 23:50, 27 October 2010

Safety

Would any of your project ideas raise safety issues in terms of: researcher safety,
public safety, or environmental safety?


Since our project doesn’t involve producing dangerous products, nor any modification that could be pathogen, there is no evident issues concerning public or the researcher’s safety , except the well-known risks of all molecular biology researches.
Of course, any bacterial modification implies the risk of genetic transduction in other bacteria, which consequences we cannot predict; that’s why we have designed a way to prevent the bacteria from escapping. (see Cell Death module)
Environmentally speaking, the energy source used by bacteria is obtained from wastewaters, and residual carbone is found, at the end of the process, in the bacterial sludge, so the global carbone balance is null. Furthermore, the dihydrogen produced could be used as an alternative to other pollutive and limited energy sources.


Do any of the new BioBrick parts (or devices) that you made this year
raise any safety issues?

No, all of the BioBricks we sent or intended to send were made from DNA parts usually used in our host lab, with no particular safety issues.


Is there a local biosafety group, committee, or review board at your
institution?

Yes, there is a biosafety committee specific of the ULB Institute of Molecular Biology and Medicine, which was our host lab. This committee authorizes or refuses any new project to be carried in the institute, including end of studies works and thesis, which is routine, except if the project includes, for example, the manipulation of pathogenic organisms.
See the Bioethics part, section biosecurity for more detailed explanation about the standard protocol to follow in Belgium, in order to obtain the authorization to carry out a new experimentation.


If yes, what does your local biosafety group think about your project?

Since all the DNA parts we designed were already used, in different projects in our host lab, our project was considered routine and was not subject to any specific decision of the committee. We didn’t have special presentations to do or forms to fill and obtained quite automatically the authorization to manipulate.


If no, which specific biosafety rules or guidelines do you have to
consider in your country?
Do you have any other ideas how to deal with safety issues that could
be useful for future iGEM competitions? How could parts, devices and
systems be made even safer through biosafety engineering?

Perhaps potential pathogens or environmentally problematic parts should be referenced, with a dangerousness rate, based on a standard classification.
More drastically, having a standardized cell death system that could be easily implemented in any cell or project presenting safety issues could be helpful.

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