Team:GeorgiaTech/Ethics and Safety
From 2010.igem.org
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+ | <p><center><font color="#FFFFFF" size=5><b>Overview</b></font></center></p> | ||
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+ | <p><center><font color="#FFFFFF" size=5><b>Overview</b></font></center></p> | ||
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+ | <td bgcolor="#964141" width="800"><font color="#FFFFFF"><p>1. Would any of your project ideas raise safety issues in terms of:</p> | ||
+ | <center><table width="600" border="0" cellpadding="2" cellspacing="10"> | ||
+ | <tr> | ||
+ | <ul><font color="#FFFFFF"> | ||
+ | <li>researcher safety,</li> | ||
+ | <li>public safety, or</li> | ||
+ | <li>environmental safety?</li> | ||
+ | </ul> | ||
+ | <p>Our idea involves the insertion of the AOX gene from the sacred lotus, which redirects energy from the | ||
+ | metabolic system to be released as heat in response to a cold-shock. The protein product produced is | ||
+ | directed to the inner membrane of the cell, and not released into the environment. As our research | ||
+ | is confined to in vitro usage at this point, and the components used have no known adverse effects | ||
+ | on the environment, there is very little risk associated with a potential accident involving our project. | ||
+ | The research pursued does not pose any known safety hazards to researchers, the public, or the | ||
+ | environment. The strains of E. coli we utilized were non-pathogenic, standard lab strains that are safely | ||
+ | used in a Biosafety Level 1 laboratory setting.</p> | ||
+ | |||
+ | <p>2. Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues? If yes,</p> | ||
+ | <ul><font color="#FFFFFF"> | ||
+ | <li>Did you document these issues in the Registry?</li> | ||
+ | <li>How did you manage to handle the safety issue?</li> | ||
+ | <li>How could other teams learn from your experience?</li> | ||
+ | </ul> | ||
+ | |||
+ | <p>We constructed a bacterial plasmid containing the AOX gene with a targeting sequence, OmpA, and | ||
+ | promoter, HybB, which have no known biosafety issues.</p> | ||
+ | |||
+ | <p>3. Is there a local biosafety group, committee, or review board at your institution?</p> | ||
+ | |||
+ | <ul><font color="#FFFFFF"> | ||
+ | <li>If yes, what does your local biosafety group think about your project?</li> | ||
+ | <li>If no, which specific biosafety rules or guidelines do you have to consider in your | ||
+ | country?</li> | ||
+ | </ul> | ||
+ | |||
+ | <p>The Occupational Health and Safety Committee and the Environmental Health and Safety Office | ||
+ | of the Georgia Institute of Technology has approved Professor Eric Gaucher’s laboratory for | ||
+ | Biosafety Level 1 Research.</p> | ||
+ | |||
+ | <p>4. Do you have any other ideas how to deal with safety issues that could be useful for future | ||
+ | iGEM competitions? How could parts, devices and systems be made even safer through | ||
+ | biosafety engineering?</p> | ||
+ | |||
+ | <p>Our group has discussed the sharp learning curve associated with the first year of a team’s experience | ||
+ | with iGEM. Although our institution offered, and we all attended, a biological laboratory safety class, | ||
+ | there were many things we learned along the way, specific to research performed in the bacterial | ||
+ | genetic engineering laboratory. We would propose a collaboration of iGEM members to produce an | ||
+ | online, visual, one-hour introductory course on the basic biosafety issues that could arise during the | ||
+ | iGEM research process.</p> | ||
+ | |||
<hr> | <hr> | ||
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Revision as of 15:24, 27 October 2010
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Team Member
Atta Hassan | Marc Pline's Bio Safety Training |
---|---|
Debika Mitra | MSE Safety Training |
Amy Schwartz | Marc Pline's Bio Safety Training |
Mitesh Agrawal | Marc Pline's Bio Safety Training |
Monica Huynh | Marc Pline's Bio Safety Training |
Margo Clark | Marc Pline's Bio Safety Training |
Gita Mahmoudabadi | Marc Pline's Bio Safety Training |
Christian Mandrycky | Marc Pline's Bio Safety Training |
Sid Tantia | Marc Pline's Bio Safety Training |
Scott Holmes | Marc Pline's Bio Safety Training |
Note: Marc Pline is from the GT School of Biology
1. Would any of your project ideas raise safety issues in terms of: |