Team:Northwestern/Brainstorm

Round 1: Group Brainstorming Session

Health/Medicine

   Release in presence of wound signal (pH) Factor VIII
   Symbiosis with human body
   Selective phagocytosis (absorb toxin)
   Selective phagocytosis (lead)
   Phagocytosis for drug overdoses
   Drug sensing bactera
   Bacterial spermicide        
   Drug delivery method through WBC
   Apoptosis with drug delivery when disease is recognized
   Vitamin and mineral delivery
   Bacteria that takes up excess ions in the body
   Self Healing material: growth factor
   Apoptosis in presence of a particular disease
   Swine Flu testing on site
   Target bad cells selectively based on offset in circadian rythmn
   Cure celiac’s with bacteria
   Ethrypoeitin production in e. coli
   Thrombolytics in presence in LDL
   Thrombolytics in precense of clots (macrophages)
   Bacterial pacemakers

Food/Energy

   Supplementary vitamin and minerals to be grown on produce
   Removable pesticide bacterial film
   Cheese reservatrol
   Splitting Hydrogen from water
   Electrogenesis: produce voltage from bacteria

Environment

   Consume gases in the air (ozone)
   Consume (CFCs)
   On site radiation testing (make it click like a Geiger counter) 
   Breaking down plastics (look at past presentation)
   Photo-driven battery

Manufacturing/Industrial

   Trace explosive Bacteria
   EXPLODING BACTERIA
   Bacterial Superglue
   Resistors
   Capacitors (Storing charge)
   Phagocytosis for water in shoes
   Bacterial barometer
   Bacterial paper to print on 
   Active pH buffer for e. coli (target pH)    
   pH meter
   Cilia creating fluid flow, generating fluid current
   Create ferrofluuid to create magnetism
   Bacteria to regulate the temperature of a surface (endothermic and exothermic reaction)
   Long lasting bacterial sunblock
   Bacterial Clothing 
   Thermal heating for toes
   Adjusting Young’s Modulus
   Contracting  group of cells
   Thermometer
   Bacterial film that responds to laser so you can sketch on it. (express GFP light induced promoter)
   Bacterial Gears 
 

Miscellaneous

   ELISA for DNA
   ELISA for mRNA
   Magnetic Bacteria 
   Faster biodegradation (Signal activated ) (isn't this environmental?)
   Oncoprotein expressed on the outside missing ligand binding portion
   Cytoskeleton in bacteria
   Engineering current flow  intracellularly
   Bacterial gyroscope
   Bacterias that produce primers
   Proteosome into e. coli design system to keep at steady state to keep e. coli alive
   Nail polish (grow back or fade away)
   Tight junctions into bacteria
   Synthetic Apoptotic signal (and isn't this medical?)
   Music Playing Bacteria: loudspeaker
   Clock using bacterial gears
   Non Newtonian fluid bacteria (using force)
   Bacteria piston using sinking and floating mechanism
   Gap junction music playing
   Rotifers: surviving without water mechanism (protein protection)
   Engineering signal glycoproteins into bacteria (integration of virus disrupts reporter gene)

Round 2: Official 2010 iGEM Draft

Each member chose 3 favorite topics to research

Sean - Opsin, Electrogenesis, Tight Junction

Avi - Proteosome, Storing Charge, Magnetic Field

Ben - Pacemaker, Factor8, Excess Ion uptake

Matt - Self Healing Material, WBC, Bacterial Thermometer

Timi - Splitting Water, Primer Production, Oncoprotein Express

Jeremy - Circadian Rhythm, pH meter, Cytoskeleton

Ragan - Selective Phagocytosis, Erythropoietin Production, Inducible Apoptosis

Round 3: Presentation and Voting

Voted on the basis of: Sexiness, Available Parts, Feasibility, and Applications

Narrowed Down to: Cytoskeleton, Magnetic Bacteria, and Self Healing Armor

Round 4: Group Discussion

Cytoskeleton Discarded

Self-Healing Armor altered to Bacterial Skin

B-Cell/T-Cell Response Modeling Introduced

Magnetic Bacteria relegated to side project

Round 5: Presentation and Final Voting

Main Project: Bacterial Skin

Side Project: Magnetic Bacteria (Magnetite Synthesis)