<p><img src="img/logo.gif" alt="Image description" width="141" height="135" title="Image title" />The  Mosquito Intelligent Terminator (MIT) is designed and optimized to be an ecological and environmental friendly mosquito pesticide. MIT is an  engineered E. coli secreting crystal proteins isolated from Bacillus thuringiensis to kill mosquito larvae, or commonly known as wrigglers. These crystal  proteins are toxic to certain types of mosquitoes  only and are not pathogenic to mammals.  We designed a temperature-dependent genetic  circuit expressing high levels of crystal proteins at room temperature only,  thus production does not occur at incubation temperature. In order to make an  environmentally safe insecticide, our design also incorporates a genetic circuit  controlling the population size of E. coli, thus a surplus will never exist as E.  coli population is self-maintained within the system. This intelligent  terminator is not limited to mosquitos only,<img class="right" src="./img/image.jpg" alt="Image description" title="Image title" /> as the intelligent terminator system can be custom fitted with  different cry genes to other insect species. Currently, with more than one  hundred crystal proteins targeting various insect species, our design may  potentially serve as a promising pest control solution in the future.  </p>