Team:UC Davis/Projects

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Revision as of 07:15, 22 September 2010


Spatial Oscillation

We would like to take a moment to thank all of our sponsors for their very generous donations, as we could not have done this without your help!

We would also like to thank and acknowledge:
Our Advisors
Marc Facciotti
Ilias Tagkopoulos
Technical Guidance
David Larsen
Andrew Yao
Visiting iGEMer
Jia Li of Zhejiang University (TEAM ZJU-China)
cI Promoter Screen
Drew Endy - Stanford
Thomas Schneider - NIH
Want to sponsor us? Send an email to mtfacciotti@ucdavis.edu to discuss various ways you can help! :)

Revision as of 07:15, 22 September 2010 (view source) Jctanti (Talk \| contribs) ← Older edit		Revision as of 07:15, 22 September 2010 (view source) Jctanti (Talk \| contribs) Newer edit →
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	<br/><br/><p class='indent'>Crosstalk can be attributed to several aspects of biological systems, one of which is the interaction between proteins from the synthetic circuit and proteins from the host organism. CPOTATo takes advantage of this fact in an attempt to predict protein combinations that may cause crosstalk in various biological systems.		<br/><br/><p class='indent'>Crosstalk can be attributed to several aspects of biological systems, one of which is the interaction between proteins from the synthetic circuit and proteins from the host organism. CPOTATo takes advantage of this fact in an attempt to predict protein combinations that may cause crosstalk in various biological systems.

-	<br/><br/><p class='indent'>The primary reason for the crosstalk between proteins is usually the homology between them. Consider the following abstract example: In the chassis' system, Protein A naturally interacts with Protein B; however, Protein C, a protein produced by the synthetic circuit we wish to implant, is very homologous to Protein A. Since Protein A and Protein C are very similar, there is a certain degree of probability that Protein C will interact with Protein B. Therefore, unless Protein C's original purpose was to interact with Protein B, this is an undesirable interaction that may lead to unpredictable crosstalk.;	+	<br/><br/><p class='indent'>The primary reason for the crosstalk between proteins is usually the homology between them. Consider the following abstract example: In the chassis' system, Protein A naturally interacts with Protein B; however, Protein C, a protein produced by the synthetic circuit we wish to implant, is very homologous to Protein A. Since Protein A and Protein C are very similar, there is a certain degree of probability that Protein C will interact with Protein B. Therefore, unless Protein C's original purpose was to interact with Protein B, this is an undesirable interaction that may lead to unpredictable crosstalk.";