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Team:Heidelberg
From 2010.igem.org
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| + | The contents and design of this wiki are published under the GNU Free Documentation License. You are granted the right to copy and modify our work, but you must publish your work under the same type of license while recognizing us the authors. | ||
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| + | Stefan Kleinsorg, Thomas Uhlig | ||
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= Project Abstract = | = Project Abstract = | ||
Revision as of 16:14, 21 September 2010
Project Abstract
miRNAs were found to be key regulators in proliferation, differentiation, apoptosis, hematopoesis and oncogenesis. Different cell types have unique and dynamic miRNA expression profiles that could be used to discriminate between those cell types and even between cellular stages. The iGEM Team Heidelberg 2010 will create miRNA binding site patterns enabling the control of any target gene of choice according to the cellular miRNA expression profile. Therefore, we will apply evolutionary methods for creating large miRNA binding site pattern libraries and we will develop two new and powerful methods for miRNA binding site pattern library screening. In parallel, computational modeling will be used for getting information on natural binding site pattern structure in order to enable rational design of complex binding site patterns recognizing certain cellular miRNA expression profiles in the future.
Sponsors
