Team:Stockholm/Modelling

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Revision as of 13:04, 26 August 2010

Figure 1

Wet-lab members are working on several proteins. The idea behind why we chose these proteins was somehow vague, because of low amount of information we had on our wiki page. In this section we try to explain the reasons and ideas behind choosing those specific proteins.

As a starting point, we began with the article [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. (2008)]. In this paper they Identified some 859 genes as being

We start by looking at several databases how the PPI map should look like for the proteins of interest, from there we can make statements about predictions or make prove of concept. One of the main articles which looked into transcriptional profile in melanocytes from vitiligo patients is Strömberg S et al. Pigment Cell Melanoma Res. (2008). For the first phase of interaction map, focuse will be on MITF. For this case, I chose several genes which are differentially regulated from Strömberg S et al. Pigment Cell Melanoma Res. (2008). foxd3, pax3 and tyrp1 are chosen (Notes from August 6 and August 5).

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-We start by looking at several databases how the PPI map should look like for the proteins of interest, from there we can make statements about predictions or make prove of concept. One of the main articles which looked into transcriptional profile in melanocytes from vitiligo patients is [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. Pigment Cell Melanoma Res. (2008)].
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+[[Image:Net_Image_confidence_View_igem_stockholm_modelling_report.png|600px|thumb|center|Figure 1]]
+Wet-lab members are working on several proteins. The idea behind why we chose these proteins was somehow vague, because of low amount of information we had on our wiki page.  In this section we try to explain the reasons and ideas behind choosing those specific proteins.
+As a starting point, we began with the article [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. (2008)]. In this paper they Identified some 859 genes as being
-For the first phase of interaction map, focuse will be on MITF. For this case, I chose several genes which are differentially regulated from [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. Pigment Cell Melanoma Res. (2008)]. foxd3, pax3 and tyrp1 are chosen (Notes from [https://2010.igem.org/Team:Stockholm/6_August_2010 August 6] and [https://2010.igem.org/Team:Stockholm/5_August_2010 August 5]).
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+We start by looking at several databases how the PPI map should look like for the proteins of interest, from there we can make statements about predictions or make prove of concept. One of the main articles which looked into transcriptional profile in melanocytes from vitiligo patients is Strömberg S et al. Pigment Cell Melanoma Res. (2008).
+For the first phase of interaction map, focuse will be on MITF. For this case, I chose several genes which are differentially regulated from Strömberg S et al. Pigment Cell Melanoma Res. (2008). foxd3, pax3 and tyrp1 are chosen (Notes from August 6 and August 5).