Team:Stockholm/Modelling

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We start by looking at several databases how the PPI map should look like for the proteins of interest, from there we can make statements about predictions or make prove of concept. One of the main articles which looked into transcriptional profile in melanocytes from vitiligo patients is [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. Pigment Cell Melanoma Res. (2008)].
We start by looking at several databases how the PPI map should look like for the proteins of interest, from there we can make statements about predictions or make prove of concept. One of the main articles which looked into transcriptional profile in melanocytes from vitiligo patients is [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. Pigment Cell Melanoma Res. (2008)].
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For the first phase of interaction map, focuse will be on MITF. For this case, I chose several genes which are differentially regulated from [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. Pigment Cell Melanoma Res. (2008)]. foxd3, pax3 and tyrp1 are chosen (Notes from [https://2010.igem.org/Team:Stockholm/6_August_2010 August 6] and [https://2010.igem.org/Team:Stockholm/5_August_2010 August 5]).

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Contents


PPI

We start by looking at several databases how the PPI map should look like for the proteins of interest, from there we can make statements about predictions or make prove of concept. One of the main articles which looked into transcriptional profile in melanocytes from vitiligo patients is [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. Pigment Cell Melanoma Res. (2008)].

For the first phase of interaction map, focuse will be on MITF. For this case, I chose several genes which are differentially regulated from [http://www.ncbi.nlm.nih.gov/pubmed/18426409 Strömberg S et al. Pigment Cell Melanoma Res. (2008)]. foxd3, pax3 and tyrp1 are chosen (Notes from August 6 and August 5).

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