Team:TU Delft/Modeling/HC regulation/Sensitivity

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Revision as of 11:28, 27 October 2010

Sensitivity analysis

For all beta parameters (lumped variables for transcriptions speed, translations speed, promoter strength and rbs strength) and all K parameters (equilibrium constant for binding of AlkS with alkanes and coefficients for the activity of promoters) a sensitivity analysis has been performed. This was done by varying the parameters from 50% of their original values to 200% of their original values.

For this range of parameter values it is checked how much the steady state concentration of AlkB is and how long it takes for 95% of the steady state concentration of AlkB to be reached from steady state values for no alkanes to steady state values for 1 µM of alkanes.

In the figures below are the results for this sensitivity analysis.

Figure 1 – Sensitivity analysis of parameter β^max_S1

Figure 2 – Sensitivity analysis of parameter β^max_S2

Figure 3 – Sensitivity analysis of parameter β^max_B

Figure 4 – Sensitivity analysis of parameter β^max_AlkS

Figure 5 – Sensitivity analysis of parameter β^max_AlkB

Figure 6 – Sensitivity analysis of parameter K_HC

Figure 7 – Sensitivity analysis of parameter K_S1

Figure 8 – Sensitivity analysis of parameter K_S2

Figure 9 – Sensitivity analysis of parameter K_B

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