Team:Sheffield/Modeling
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In the modelling section of our project we will be implementing mathematical models and computer simulations for the cholera detection biosensor. We have implemented models for the two different systems in our project | In the modelling section of our project we will be implementing mathematical models and computer simulations for the cholera detection biosensor. We have implemented models for the two different systems in our project | ||
- | 1. Chimeric protein system – the quorum sensing receptor from vibrio cholera is fused with histadine kinase BarA in E-coli | + | 1. [[Team:Sheffield/Chimeric protein system|Chimeric protein system]] – the quorum sensing receptor from vibrio cholera is fused with histadine kinase BarA in E-coli |
- | 2. Cholera protein system – the proteins that compile the signal sensing pathway in vibrio cholera is inserted in to E-coli | + | 2. [[Team:Sheffield/cholera protein system|Cholera protein system]] – the proteins that compile the signal sensing pathway in vibrio cholera is inserted in to E-coli |
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The first step in creating the model was to analyse the processes in the system mainly using research literature and the knowledge from the biologists to create the chemical equations for these processes. Next these chemical equations were used to write differential equations for the system, creating a dynamic model. The model was then implemented in matlab to show the changes in the output according to the input and the different parameters in the system. | The first step in creating the model was to analyse the processes in the system mainly using research literature and the knowledge from the biologists to create the chemical equations for these processes. Next these chemical equations were used to write differential equations for the system, creating a dynamic model. The model was then implemented in matlab to show the changes in the output according to the input and the different parameters in the system. | ||
- | To allow easy access to the model and to analyse the output easily for different parameters of the system we have created a graphical user interface (GUI) in matlab. More information on the GUI can be found at the page Graphical User Interface. | + | To allow easy access to the model and to analyse the output easily for different parameters of the system we have created a graphical user interface (GUI) in matlab. More information on the GUI can be found at the page [[Team:Sheffield/Graphical User Interface|Graphical User Interface]]. |
Revision as of 23:50, 24 October 2010