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| - | <tr height=26 style='mso-height-source:userset;height:20.1pt'>
| |
| - | <td height=26 class=xl7322116 width=172 style='height:20.1pt;width:129pt'>Mutant
| |
| - | Name</td>
| |
| - | <td class=xl7322116 width=216 style='width:162pt'>Brief Description</td>
| |
| - | <td class=xl7322116 width=297 style='width:223pt'>Features and Mutations</td>
| |
| - | <td class=xl6922116 width=168 style='width:126pt'>Transpeptidation per DCP</td>
| |
| - | <td class=xl6922116 width=168 style='width:126pt'>Hydrolysis per DCP</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=345 style='width:259pt'></td>
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| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>CapD</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A protein native to <font
| |
| - | class="font622116">Bacillus anthracis </font><font class="font022116">which
| |
| - | cleaves poly-D-γ-glutamate (PDGA) and anchors it to the bacterium's
| |
| - | peptidoglycan</font></td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>No Signal Sequence, Triple
| |
| - | band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.491</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.713</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>CapD_CP</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A circularly permuted CapD
| |
| - | with a Foldit-designed linker</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Foldit created linker,
| |
| - | Circular Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.000</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.000</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=345 style='width:259pt'></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>CapD_CPNFDelta</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A circularly permuted CapD
| |
| - | with deletion of floppy areas</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Foldit created linker,
| |
| - | Circular Permutation, No Signal Sequence, Single band on protein agarose gel,
| |
| - | Removed "floppy" section to compact protein</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.035</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.878</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>F24A</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 24 on CapDCP from Phenylalanine to Alanine, Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.021</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.061</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F24H</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 24 on CapDCP from Phenylalanine to Histidine, Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.108</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>1.205</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F24H,
| |
| - | L40R, T59D_M61S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24, 40, 59, and 61 on Foldit design from Phenylalanine to Histidine, Leucine
| |
| - | to Arginine, Threonine to Asparagine, and Methionine to Serine, respectively.
| |
| - | Foldit-created linker, Circular Permutation, No Signal Sequence, Single band
| |
| - | on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.001</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.006</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F24H,
| |
| - | L40R, T59N_M61S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24, 40, 59, and 61 on Foldit design from Phenylalanine to Histidine, Leucine
| |
| - | to Arginine, Threonine to Aspartic Acid, and Methionine to Serine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.058</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>1.050</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F24H,
| |
| - | L40R, T59S_M61S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24, 40, 59, and 61 on CapDCP from Phenylalanine to Histidine, Leucine to
| |
| - | Arginine, Threonine to Serine, and Methionine to Serine, respectively.
| |
| - | Foldit-created linker, Circular Permutation, No Signal Sequence, Single band
| |
| - | on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.007</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>F24H,
| |
| - | R356K</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24 and 356 on CapDCP from Phenylalanine to Histidine and Arginine to Lysine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.129</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.257</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F24H,
| |
| - | T59R</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24 and 59 on CapDCPfrom Phenylalanine to Histidine and Threonine to Arginine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.011</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.005</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>F24H,T59N</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24 and 59 on CapDCP from Phenylalanine to Histidine and Threonine to
| |
| - | Asparagine, respectively. Foldit-created linker, Circular Permutation, No
| |
| - | Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.007</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.029</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F24W</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 24 on CapDCP from Phenylalanine to Tryptophan. Foldit-created linker,
| |
| - | Circular Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.006</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.044</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>F24Y</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 24 on CapDCP from Phenylalanine to Tyrosine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.593</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.887</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F24Y,
| |
| - | L40R</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24 and 40 on CapDCP from Phenylalanine to Tyrosine and Leucine to Arginine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.009</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>-0.013</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F24Y,
| |
| - | L40R, T59N</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24, 40, 59 on CapDCP from Phenylalanine to Tyrosine, Leucine to
| |
| - | Arginine,<span style='mso-spacerun:yes'> </span>and Threonine to Asparagine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.003</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.157</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>F24Y,R305K</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24 and 305 on CapDCP from Phenylalanine to Tyrosine and Arginine to Lysine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.002</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.233</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>F24Y,T59N</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24 and 59 on CapDCP from Phenylalanine to Tyrosine and Threonine to
| |
| - | Asparagine, respectively. Foldit-created linker, Circular Permutation, No
| |
| - | Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.008</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.165</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>F24Y,T59N,R305K</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 24, 59, and 356 on CapDCP from Phenylalanine to Tyrosine, Threonine to
| |
| - | Asparagine, and Arginine to Lysine, respectively. Foldit-created linker,
| |
| - | Circular Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.002</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.127</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>F60W</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 60 on CapDCP from Phenylalanine to Tryptophan. Foldit-created linker,
| |
| - | Circular Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.239</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.489</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>G79A</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 79 on CapDCP from Glycine to Alanine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.040</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.511</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>I83T</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 83 on CapDCP from Isoleucine to Threonine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.009</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.006</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>I83V</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 83 on CapDCP from Isoleucine to Valine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.003</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.043</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>L40A</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 40 on CapDCP from Leucine to Alanine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.150</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.413</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>L40R</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 40 on CapDCP from Leucine to Arginine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.157</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.527</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>L40S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 40 on CapDCP from Leucine to Serine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.166</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.577</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>L40W</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 40 on CapDCP from Leucine to Tryptophan. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.825</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.215</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>M61H</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 61 on CapDCP from Methionine to Histidine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.003</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.002</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>M61N</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 61 on CapDCP from Methionine to Asparagine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.011</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.002</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>M61S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 61 on CapDCP from Methionine to Serine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.262</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.485</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>N23K</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 23 on CapDCP from Asparagine to Lysine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.818</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.839</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>N23Q</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 23 on CapDCP from Asparagine to Glutamine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.165</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.646</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>S143K</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 143 on CapDCP from Serine to Lysine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.574</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.426</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>S22I,
| |
| - | T59A</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 22 and 59 on CapDCP from Serine to Isoleucine and Threonine to Alanine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.030</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.057</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>S22Q,
| |
| - | T59Q</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 22 and 59 on CapDCP from Serine to Glutamine and Threonine to Glutamine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.012</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.085</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>S57H,
| |
| - | M61H</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 57 and 61 on CapDCP from Serine to Histidine and Methionine to Histidine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.004</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.007</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T18L,
| |
| - | T59Q, M61N, F452W</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 18, 59, 61, and 452 on CapDCP from Threonine to Leucine, Threonine to
| |
| - | Glutamine, Methionine to Asparagine, and Phenylalanine to Tryptophan,<span
| |
| - | style='mso-spacerun:yes'> </span>respectively. Foldit-created linker,
| |
| - | Circular Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.020</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.028</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T18S_T20S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 18 and 20 on CapDCP from Threonine to Serine and Threonine to Serine,<span
| |
| - | style='mso-spacerun:yes'> </span>respectively. Foldit-created linker,
| |
| - | Circular Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.617</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.186</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20A</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 20 on CapDCP from Threonine to Alanine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.011</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.021</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20C</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 20 on CapDCP from Threonine to Cystine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.090</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.142</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 20 on CapDCP from Threonine to Serine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.639</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.443</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40D</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 40 on CapDCP from Threonine to Serine and Leucine to Asparagine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.853</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.001</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40E</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 40 on CapDCP from Threonine to Serine and Leucine to Glutamic Acid,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.163</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.637</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40F</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 40 on CapDCP from Threonine to Serine and Leucine to Phenylalanine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.246</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.335</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40H</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 40 on CapDCP from Threonine to Serine and Leucine to Histidine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.001</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.012</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40K</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 40 on CapDCP from Threonine to Serine and Leucine to Lysine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.007</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40Q</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 40 on CapDCP from Threonine to Serine and Leucine to Glutamine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.126</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.478</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40R</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 40 on CapDCP from Threonine to Serine and Leucine to Arginine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.009</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40R, F60E</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and
| |
| - | Phenylalanine to Glutamic Acid, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.048</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.028</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40R, F60Q</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and
| |
| - | Phenylalanine to Glutamine, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.002</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.007</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40R, N81E</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and
| |
| - | Phenylalanine to Glutamine, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.001</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>-0.004</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40R, N81Q</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 40, and 81 on CapDCP from Threonine to Serine, Leucine to Arginine, and
| |
| - | Asparagine to Glutamine, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.422</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.321</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40R, T59K</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 40, and 59 on CapDCP from Threonine to Serine, Leucine to Arginine, and
| |
| - | Threonine to Lysine, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.048</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.033</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl7022116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | L40R, T59K_M61S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 40, 59, and 61 on CapDCP from Threonine to Serine, Leucine to Arginine,
| |
| - | Threonine to Lysine, and Methionine to Serine, respectively. Foldit-created
| |
| - | linker, Circular Permutation, No Signal Sequence, Single band on protein agarose
| |
| - | gel</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.010</td>
| |
| - | <td class=xl7122116 width=168 style='width:126pt'>0.032</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6722116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,
| |
| - | T59Q, M61T</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 59, and 61 on CapDCP from Threonine to Serine, Threonine to Glutamine,
| |
| - | and Methionine to Threonine, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.007</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.069</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61A</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Alanine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.005</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.045</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61C</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Cystine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.102</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.207</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61D</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Aspartic Acid,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.004</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.003</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61G</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Glycine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.004</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.029</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61L</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Leucine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.004</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.029</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61N</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Asparagine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.003</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.002</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Serine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.007</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.053</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61T</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Threonine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.038</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.363</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,M61V</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 61 on CapDCP from Threonine to Serine and Methionine to Valine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.004</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.039</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,T59N</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 59 on CapDCP from Threonine to Serine and Threonine to Asparagine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.019</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.125</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S,T59S_M61S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 59, and 61 on CapDCP from Threonine to Serine, Threonine to Serine, and
| |
| - | Methionine to Serine, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.300</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.719</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S_F24H</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 24 on CapDCP from Threonine to Serine and Phenylalanine to Histidine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.008</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.097</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S_F24Y</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20 and 24 on CapDCP from Threonine to Serine and Phenylalanine to Tyrosine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.040</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.201</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T20S_F24Y,T59N</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 20, 24, and 59 on CapDCP from Threonine to Serine, Phenylalanine to Tyrosine,
| |
| - | and Threonine to Asparagine, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.013</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.048</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T2A</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue 2
| |
| - | on CapDCP from Threonine to Alanine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.007</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.020</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T2C</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at destroying all activity with poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue 2
| |
| - | on CapDCP from Threonine to Cystine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.001</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.005</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T2S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue 2
| |
| - | on CapDCP from Threonine to Serine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.024</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.325</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T2S,T18S_T20S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 2, 18, and 20 on CapDCP from Threonine to Serine, Threonine to Serine, and
| |
| - | Threonine to Serine, respectively. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.144</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.250</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T2S,T18S_T20S,T59S_M61S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 2, 18, 20, 59, and 61 on CapDCP from Threonine to Serine, Threonine to
| |
| - | Serine, Threonine to Serine, Threonine to Serine and Threonine to Serine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.003</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.022</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T2S,T20S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 2 and 20 on CapDCP from Threonine to Serine and Threonine to Serine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.106</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.089</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T2V</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at destroying all activity with poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue 2
| |
| - | on CapDCP from Threonine to Valine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T59H_M61A</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 59 and 61 on CapDCP from Threonine to Histidine and Methionine to Alanine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T59H_M61T</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 59 and 61 on CapDCP from Threonine to Histidine and Methionine to Threonine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T59M</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 59 on CapDCP from Threonine to Methionine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.008</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.008</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T59N</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 59 on CapDCP from Threonine to Asparagine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.232</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.868</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T59Q</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 59 on CapDCP from Threonine to Glutamine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.000</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T59Q,
| |
| - | M61Q, F452W</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 59, 61, and 452 on CapDCP from Threonine to Glutamine, Threonine to
| |
| - | Glutamine, and Phenylalanine to Tryptophan, respectively. Foldit-created
| |
| - | linker, Circular Permutation, No Signal Sequence, Single band on protein
| |
| - | agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>-0.014</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.037</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T59S</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residue
| |
| - | 59 on CapDCP from Threonine to Serine. Foldit-created linker, Circular
| |
| - | Permutation, No Signal Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>3.525</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>1.047</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl6922116 width=172 style='height:69.95pt;width:129pt'>T59S,
| |
| - | M61H</td>
| |
| - | <td class=xl6822116 width=216 style='width:162pt'>A mutated CapDCP protein
| |
| - | aimed at increasing hydrolysis and decreasing transpeptidation of
| |
| - | poly-D-gamma-glutamate.</td>
| |
| - | <td class=xl6822116 width=297 style='width:223pt'>Point mutation at residues
| |
| - | 59 and 61 on CapDCP from Threonine to Serine and Methionine to Histidine,
| |
| - | respectively. Foldit-created linker, Circular Permutation, No Signal
| |
| - | Sequence, Single band on protein agarose gel</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.013</td>
| |
| - | <td class=xl7222116 width=168 style='width:126pt'>0.051</td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl6622116 width=126 style='width:95pt'></td>
| |
| - | <td class=xl6622116 width=125 style='width:94pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl1522116 style='height:69.95pt'></td>
| |
| - | <td class=xl6622116 width=216 style='width:162pt'></td>
| |
| - | <td class=xl6622116 width=297 style='width:223pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=345 style='width:259pt'></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl1522116></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl1522116 style='height:69.95pt'></td>
| |
| - | <td class=xl6622116 width=216 style='width:162pt'></td>
| |
| - | <td class=xl6622116 width=297 style='width:223pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=345 style='width:259pt'></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl1522116></td>
| |
| - | </tr>
| |
| - | <tr height=93 style='mso-height-source:userset;height:69.95pt'>
| |
| - | <td height=93 class=xl1522116 style='height:69.95pt'></td>
| |
| - | <td class=xl6622116 width=216 style='width:162pt'></td>
| |
| - | <td class=xl6622116 width=297 style='width:223pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=168 style='width:126pt'></td>
| |
| - | <td class=xl6622116 width=345 style='width:259pt'></td>
| |
| - | <td class=xl6622116 width=146 style='width:110pt'></td>
| |
| - | <td class=xl6622116 width=199 style='width:149pt'></td>
| |
| - | <td class=xl6622116 width=165 style='width:124pt'></td>
| |
| - | <td class=xl6622116 width=87 style='width:65pt'></td>
| |
| - | <td class=xl6622116 width=64 style='width:48pt'></td>
| |
| - | <td class=xl6622116 width=136 style='width:102pt'></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl1522116></td>
| |
| - | <td class=xl1522116></td>
| |
| - | </tr>
| |
| - | <![if supportMisalignedColumns]>
| |
| - | <tr height=0 style='display:none'>
| |
| - | <td width=172 style='width:129pt'></td>
| |
| - | <td width=216 style='width:162pt'></td>
| |
| - | <td width=297 style='width:223pt'></td>
| |
| - | <td width=168 style='width:126pt'></td>
| |
| - | <td width=168 style='width:126pt'></td>
| |
| - | <td width=168 style='width:126pt'></td>
| |
| - | <td width=345 style='width:259pt'></td>
| |
| - | <td width=146 style='width:110pt'></td>
| |
| - | <td width=199 style='width:149pt'></td>
| |
| - | <td width=165 style='width:124pt'></td>
| |
| - | <td width=87 style='width:65pt'></td>
| |
| - | <td width=64 style='width:48pt'></td>
| |
| - | <td width=136 style='width:102pt'></td>
| |
| - | <td width=126 style='width:95pt'></td>
| |
| - | <td width=125 style='width:94pt'></td>
| |
| - | <td width=168 style='width:126pt'></td>
| |
| - | </tr>
| |
| - | <![endif]>
| |
| - | </table>
| |
| | | | |
| - | </div>
| |
| | | | |
| | + | var c_rgszClr=new Array(8); |
| | + | c_rgszClr[0]="window"; |
| | + | c_rgszClr[1]="buttonface"; |
| | + | c_rgszClr[2]="windowframe"; |
| | + | c_rgszClr[3]="windowtext"; |
| | + | c_rgszClr[4]="threedlightshadow"; |
| | + | c_rgszClr[5]="threedhighlight"; |
| | + | c_rgszClr[6]="threeddarkshadow"; |
| | + | c_rgszClr[7]="threedshadow"; |
| | | | |
| - | <!-----------------------------> | + | var g_iShCur; |
| - | <!--END OF OUTPUT FROM EXCEL PUBLISH AS WEB PAGE WIZARD--> | + | var g_rglTabX=new Array(c_lTabs); |
| - | <!-----------------------------> | + | |
| - | </body> | + | function fnGetIEVer() |
| | + | { |
| | + | var ua=window.navigator.userAgent |
| | + | var msie=ua.indexOf("MSIE") |
| | + | if (msie>0 && window.navigator.platform=="Win32") |
| | + | return parseInt(ua.substring(msie+5,ua.indexOf(".", msie))); |
| | + | else |
| | + | return 0; |
| | + | } |
| | + | |
| | + | function fnBuildFrameset() |
| | + | { |
| | + | var szHTML="<frameset rows=\"*,18\" border=0 width=0 frameborder=no framespacing=0>"+ |
| | + | "<frame src=\""+document.all.item("shLink")[0].href+"\" name=\"frSheet\" noresize>"+ |
| | + | "<frameset cols=\"54,*\" border=0 width=0 frameborder=no framespacing=0>"+ |
| | + | "<frame src=\"\" name=\"frScroll\" marginwidth=0 marginheight=0 scrolling=no>"+ |
| | + | "<frame src=\"\" name=\"frTabs\" marginwidth=0 marginheight=0 scrolling=no>"+ |
| | + | "</frameset></frameset><plaintext>"; |
| | + | |
| | + | with (document) { |
| | + | open("text/html","replace"); |
| | + | write(szHTML); |
| | + | close(); |
| | + | } |
| | + | |
| | + | fnBuildTabStrip(); |
| | + | } |
| | + | |
| | + | function fnBuildTabStrip() |
| | + | { |
| | + | var szHTML= |
| | + | "<html><head><style>.clScroll {font:8pt Courier New;color:"+c_rgszClr[6]+";cursor:default;line-height:10pt;}"+ |
| | + | ".clScroll2 {font:10pt Arial;color:"+c_rgszClr[6]+";cursor:default;line-height:11pt;}</style></head>"+ |
| | + | "<body onclick=\"event.returnValue=false;\" ondragstart=\"event.returnValue=false;\" onselectstart=\"event.returnValue=false;\" bgcolor="+c_rgszClr[4]+" topmargin=0 leftmargin=0><table cellpadding=0 cellspacing=0 width=100%>"+ |
| | + | "<tr><td colspan=6 height=1 bgcolor="+c_rgszClr[2]+"></td></tr>"+ |
| | + | "<tr><td style=\"font:1pt\"> <td>"+ |
| | + | "<td valign=top id=tdScroll class=\"clScroll\" onclick=\"parent.fnFastScrollTabs(0);\" onmouseover=\"parent.fnMouseOverScroll(0);\" onmouseout=\"parent.fnMouseOutScroll(0);\"><a>«</a></td>"+ |
| | + | "<td valign=top id=tdScroll class=\"clScroll2\" onclick=\"parent.fnScrollTabs(0);\" ondblclick=\"parent.fnScrollTabs(0);\" onmouseover=\"parent.fnMouseOverScroll(1);\" onmouseout=\"parent.fnMouseOutScroll(1);\"><a><</a></td>"+ |
| | + | "<td valign=top id=tdScroll class=\"clScroll2\" onclick=\"parent.fnScrollTabs(1);\" ondblclick=\"parent.fnScrollTabs(1);\" onmouseover=\"parent.fnMouseOverScroll(2);\" onmouseout=\"parent.fnMouseOutScroll(2);\"><a>></a></td>"+ |
| | + | "<td valign=top id=tdScroll class=\"clScroll\" onclick=\"parent.fnFastScrollTabs(1);\" onmouseover=\"parent.fnMouseOverScroll(3);\" onmouseout=\"parent.fnMouseOutScroll(3);\"><a>»</a></td>"+ |
| | + | "<td style=\"font:1pt\"> <td></tr></table></body></html>"; |
| | + | |
| | + | with (frames['frScroll'].document) { |
| | + | open("text/html","replace"); |
| | + | write(szHTML); |
| | + | close(); |
| | + | } |
| | + | |
| | + | szHTML = |
| | + | "<html><head>"+ |
| | + | "<style>A:link,A:visited,A:active {text-decoration:none;"+"color:"+c_rgszClr[3]+";}"+ |
| | + | ".clTab {cursor:hand;background:"+c_rgszClr[1]+";font:9pt Arial;padding-left:3px;padding-right:3px;text-align:center;}"+ |
| | + | ".clBorder {background:"+c_rgszClr[2]+";font:1pt;}"+ |
| | + | "</style></head><body onload=\"parent.fnInit();\" onselectstart=\"event.returnValue=false;\" ondragstart=\"event.returnValue=false;\" bgcolor="+c_rgszClr[4]+ |
| | + | " topmargin=0 leftmargin=0><table id=tbTabs cellpadding=0 cellspacing=0>"; |
| | + | |
| | + | var iCellCount=(c_lTabs+1)*2; |
| | + | |
| | + | var i; |
| | + | for (i=0;i<iCellCount;i+=2) |
| | + | szHTML+="<col width=1><col>"; |
| | + | |
| | + | var iRow; |
| | + | for (iRow=0;iRow<6;iRow++) { |
| | + | |
| | + | szHTML+="<tr>"; |
| | + | |
| | + | if (iRow==5) |
| | + | szHTML+="<td colspan="+iCellCount+"></td>"; |
| | + | else { |
| | + | if (iRow==0) { |
| | + | for(i=0;i<iCellCount;i++) |
| | + | szHTML+="<td height=1 class=\"clBorder\"></td>"; |
| | + | } else if (iRow==1) { |
| | + | for(i=0;i<c_lTabs;i++) { |
| | + | szHTML+="<td height=1 nowrap class=\"clBorder\"> </td>"; |
| | + | szHTML+= |
| | + | "<td id=tdTab height=1 nowrap class=\"clTab\" onmouseover=\"parent.fnMouseOverTab("+i+");\" onmouseout=\"parent.fnMouseOutTab("+i+");\">"+ |
| | + | "<a href=\""+document.all.item("shLink")[i].href+"\" target=\"frSheet\" id=aTab> "+c_rgszSh[i]+" </a></td>"; |
| | + | } |
| | + | szHTML+="<td id=tdTab height=1 nowrap class=\"clBorder\"><a id=aTab> </a></td><td width=100%></td>"; |
| | + | } else if (iRow==2) { |
| | + | for (i=0;i<c_lTabs;i++) |
| | + | szHTML+="<td height=1></td><td height=1 class=\"clBorder\"></td>"; |
| | + | szHTML+="<td height=1></td><td height=1></td>"; |
| | + | } else if (iRow==3) { |
| | + | for (i=0;i<iCellCount;i++) |
| | + | szHTML+="<td height=1></td>"; |
| | + | } else if (iRow==4) { |
| | + | for (i=0;i<c_lTabs;i++) |
| | + | szHTML+="<td height=1 width=1></td><td height=1></td>"; |
| | + | szHTML+="<td height=1 width=1></td><td></td>"; |
| | + | } |
| | + | } |
| | + | szHTML+="</tr>"; |
| | + | } |
| | + | |
| | + | szHTML+="</table></body></html>"; |
| | + | with (frames['frTabs'].document) { |
| | + | open("text/html","replace"); |
| | + | charset=document.charset; |
| | + | write(szHTML); |
| | + | close(); |
| | + | } |
| | + | } |
| | + | |
| | + | function fnInit() |
| | + | { |
| | + | g_rglTabX[0]=0; |
| | + | var i; |
| | + | for (i=1;i<=c_lTabs;i++) |
| | + | with (frames['frTabs'].document.all.tbTabs.rows[1].cells[fnTabToCol(i-1)]) |
| | + | g_rglTabX[i]=offsetLeft+offsetWidth-6; |
| | + | } |
| | + | |
| | + | function fnTabToCol(iTab) |
| | + | { |
| | + | return 2*iTab+1; |
| | + | } |
| | + | |
| | + | function fnNextTab(fDir) |
| | + | { |
| | + | var iNextTab=-1; |
| | + | var i; |
| | + | |
| | + | with (frames['frTabs'].document.body) { |
| | + | if (fDir==0) { |
| | + | if (scrollLeft>0) { |
| | + | for (i=0;i<c_lTabs&&g_rglTabX[i]<scrollLeft;i++); |
| | + | if (i<c_lTabs) |
| | + | iNextTab=i-1; |
| | + | } |
| | + | } else { |
| | + | if (g_rglTabX[c_lTabs]+6>offsetWidth+scrollLeft) { |
| | + | for (i=0;i<c_lTabs&&g_rglTabX[i]<=scrollLeft;i++); |
| | + | if (i<c_lTabs) |
| | + | iNextTab=i; |
| | + | } |
| | + | } |
| | + | } |
| | + | return iNextTab; |
| | + | } |
| | + | |
| | + | function fnScrollTabs(fDir) |
| | + | { |
| | + | var iNextTab=fnNextTab(fDir); |
| | + | |
| | + | if (iNextTab>=0) { |
| | + | frames['frTabs'].scroll(g_rglTabX[iNextTab],0); |
| | + | return true; |
| | + | } else |
| | + | return false; |
| | + | } |
| | + | |
| | + | function fnFastScrollTabs(fDir) |
| | + | { |
| | + | if (c_lTabs>16) |
| | + | frames['frTabs'].scroll(g_rglTabX[fDir?c_lTabs-1:0],0); |
| | + | else |
| | + | if (fnScrollTabs(fDir)>0) window.setTimeout("fnFastScrollTabs("+fDir+");",5); |
| | + | } |
| | + | |
| | + | function fnSetTabProps(iTab,fActive) |
| | + | { |
| | + | var iCol=fnTabToCol(iTab); |
| | + | var i; |
| | + | |
| | + | if (iTab>=0) { |
| | + | with (frames['frTabs'].document.all) { |
| | + | with (tbTabs) { |
| | + | for (i=0;i<=4;i++) { |
| | + | with (rows[i]) { |
| | + | if (i==0) |
| | + | cells[iCol].style.background=c_rgszClr[fActive?0:2]; |
| | + | else if (i>0 && i<4) { |
| | + | if (fActive) { |
| | + | cells[iCol-1].style.background=c_rgszClr[2]; |
| | + | cells[iCol].style.background=c_rgszClr[0]; |
| | + | cells[iCol+1].style.background=c_rgszClr[2]; |
| | + | } else { |
| | + | if (i==1) { |
| | + | cells[iCol-1].style.background=c_rgszClr[2]; |
| | + | cells[iCol].style.background=c_rgszClr[1]; |
| | + | cells[iCol+1].style.background=c_rgszClr[2]; |
| | + | } else { |
| | + | cells[iCol-1].style.background=c_rgszClr[4]; |
| | + | cells[iCol].style.background=c_rgszClr[(i==2)?2:4]; |
| | + | cells[iCol+1].style.background=c_rgszClr[4]; |
| | + | } |
| | + | } |
| | + | } else |
| | + | cells[iCol].style.background=c_rgszClr[fActive?2:4]; |
| | + | } |
| | + | } |
| | + | } |
| | + | with (aTab[iTab].style) { |
| | + | cursor=(fActive?"default":"hand"); |
| | + | color=c_rgszClr[3]; |
| | + | } |
| | + | } |
| | + | } |
| | + | } |
| | + | |
| | + | function fnMouseOverScroll(iCtl) |
| | + | { |
| | + | frames['frScroll'].document.all.tdScroll[iCtl].style.color=c_rgszClr[7]; |
| | + | } |
| | + | |
| | + | function fnMouseOutScroll(iCtl) |
| | + | { |
| | + | frames['frScroll'].document.all.tdScroll[iCtl].style.color=c_rgszClr[6]; |
| | + | } |
| | + | |
| | + | function fnMouseOverTab(iTab) |
| | + | { |
| | + | if (iTab!=g_iShCur) { |
| | + | var iCol=fnTabToCol(iTab); |
| | + | with (frames['frTabs'].document.all) { |
| | + | tdTab[iTab].style.background=c_rgszClr[5]; |
| | + | } |
| | + | } |
| | + | } |
| | + | |
| | + | function fnMouseOutTab(iTab) |
| | + | { |
| | + | if (iTab>=0) { |
| | + | var elFrom=frames['frTabs'].event.srcElement; |
| | + | var elTo=frames['frTabs'].event.toElement; |
| | + | |
| | + | if ((!elTo) || |
| | + | (elFrom.tagName==elTo.tagName) || |
| | + | (elTo.tagName=="A" && elTo.parentElement!=elFrom) || |
| | + | (elFrom.tagName=="A" && elFrom.parentElement!=elTo)) { |
| | + | |
| | + | if (iTab!=g_iShCur) { |
| | + | with (frames['frTabs'].document.all) { |
| | + | tdTab[iTab].style.background=c_rgszClr[1]; |
| | + | } |
| | + | } |
| | + | } |
| | + | } |
| | + | } |
| | + | |
| | + | function fnSetActiveSheet(iSh) |
| | + | { |
| | + | if (iSh!=g_iShCur) { |
| | + | fnSetTabProps(g_iShCur,false); |
| | + | fnSetTabProps(iSh,true); |
| | + | g_iShCur=iSh; |
| | + | } |
| | + | } |
| | + | |
| | + | window.g_iIEVer=fnGetIEVer(); |
| | + | if (window.g_iIEVer>=4) |
| | + | fnBuildFrameset(); |
| | + | //--> |
| | + | </script> |
| | + | <![endif]><!--[if gte mso 9]><xml> |
| | + | <x:ExcelWorkbook> |
| | + | <x:ExcelWorksheets> |
| | + | <x:ExcelWorksheet> |
| | + | <x:Name>MutantData Table</x:Name> |
| | + | <x:WorksheetSource HRef="MutantData%20Table_files/sheet001.htm"/> |
| | + | </x:ExcelWorksheet> |
| | + | </x:ExcelWorksheets> |
| | + | <x:Stylesheet HRef="MutantData%20Table_files/stylesheet.css"/> |
| | + | <x:WindowHeight>8505</x:WindowHeight> |
| | + | <x:WindowWidth>18195</x:WindowWidth> |
| | + | <x:WindowTopX>480</x:WindowTopX> |
| | + | <x:WindowTopY>60</x:WindowTopY> |
| | + | <x:ProtectStructure>False</x:ProtectStructure> |
| | + | <x:ProtectWindows>False</x:ProtectWindows> |
| | + | </x:ExcelWorkbook> |
| | + | </xml><![endif]--> |
| | + | </head> |
| | | | |
| | + | <frameset rows="*,39" border=0 width=0 frameborder=no framespacing=0> |
| | + | <frame src="MutantData%20Table_files/sheet001.htm" name="frSheet"> |
| | + | <frame src="MutantData%20Table_files/tabstrip.htm" name="frTabs" marginwidth=0 marginheight=0> |
| | + | <noframes> |
| | + | <body> |
| | + | <p>This page uses frames, but your browser doesn't support them.</p> |
| | + | </body> |
| | + | </noframes> |
| | + | </frameset> |
| | </html> | | </html> |
"