User:ThomasU/main

From 2010.igem.org

(Difference between revisions)
 
(12 intermediate revisions not shown)
Line 1: Line 1:
-
{{Template_HD2010_topheader}}
+
{{:Team:Heidelberg/Top}}
-
{{Template_HD2010_keyheader}}
+
{{:Team:Heidelberg/Key}}
 +
{{:Team:Heidelberg/Frame}}
<html>
<html>
<style type="text/css">
<style type="text/css">
-
#table_header_left {
+
#pics {
-
width:640px;
+
margin-left:-5px;
-
table-layout:fixed;
+
margin-right:-5px;
-
border-style:none;
+
text-align:center;
-
border-spacing:0;
+
-
vertical-align:top;
+
-
padding-top:30px;
+
-
background: url(http://igem.bioquant.uni-heidelberg.de/mediawiki/images/d/de/Main_frame_tl.png) no-repeat;
+
}
}
-
 
-
#table_header_right {
 
-
width:335px;
 
-
table-layout:fixed;
 
-
border-style:none;
 
-
border-spacing:0;
 
-
padding:100px 10px 0 35px;
 
-
vertical-align:top;
 
-
background: url(http://igem.bioquant.uni-heidelberg.de/mediawiki/images/c/ce/Main_frame_tr.png) no-repeat;
 
 +
.piclinks {
 +
border:none;
 +
text-decoration:none;
 +
position:relative;
 +
z-index:5;
}
}
 +
 +
#desc-table {
 +
width:370px;
 +
height:170px;
 +
border: none;
 +
background:transparent;
 +
margin:10px 0px;
 +
}
-
.mainwrapper {
+
#desc {
-
width:200px;
+
border: none;
-
position: relative;
+
background:transparent;
-
padding-left:0px;
+
padding:0px;
-
padding-right:0px;
+
text-align:justify;
-
vertical-align:top;
+
font-size:12pt;
-
overflow:hidden;
+
}
}
-
+
 
-
.subtable_left {
+
a { outline:0}
-
border-style:none;
+
 
-
border-spacing:0;
+
#wrapperheadline {
-
padding-left:0px;
+
position:relative;
-
margin-left:25px;
+
font-size:1.6em;
 +
font-weight:bold;
}
}
 +
 +
</style>
 +
 +
<script type="text/javascript">
-
.subtable_right {
+
var modelarray = new Array();
-
border-style:none;
+
var teamarray = new Array();
-
border-spacing:0;
+
var humanarray = new Array();
-
}
+
var notearray = new Array();
 +
var partsarray = new Array();
 +
var sponsarray = new Array();
-
#table_footer_left {
+
for (var i = 0; i <= 3; i++) {
-
width:640px;
+
modelarray[i] = new Image();
-
table-layout:fixed;
+
teamarray[i] = new Image();
-
height:80px;
+
humanarray[i] = new Image();
-
border-style:none;
+
notearray[i] = new Image();
-
border-spacing:5;
+
partsarray[i] = new Image();
-
vertical-align:top;
+
sponsarray[i] = new Image();
-
background: url(http://igem.bioquant.uni-heidelberg.de/mediawiki/images/c/cc/Main_frame_bl.png) no-repeat;
+
}
-
}
+
-
#table_footer_right {
+
modelarray[1].src="https://static.igem.org/mediawiki/2010/2/2d/Modeling_none.png";
-
width:335px;
+
modelarray[2].src="https://static.igem.org/mediawiki/2010/a/a6/Modeling_hover.png";
-
table-layout:fixed;
+
modelarray[3].src="https://static.igem.org/mediawiki/2010/e/e1/Modeling_down.png";
-
height:80px;
+
 
-
border-style:none;
+
teamarray[1].src="https://static.igem.org/mediawiki/2010/8/82/Team_none.png";
-
border-spacing:5;
+
teamarray[2].src="https://static.igem.org/mediawiki/2010/d/d2/Team_hover.png";
-
vertical-align:top;
+
teamarray[3].src="https://static.igem.org/mediawiki/2010/9/97/Team_down.png";
-
background: url(http://igem.bioquant.uni-heidelberg.de/mediawiki/images/b/bf/Main_frame_br.png) no-repeat;
+
 
 +
humanarray[1].src="https://static.igem.org/mediawiki/2010/a/a7/Human_practices_none.png";
 +
humanarray[2].src="https://static.igem.org/mediawiki/2010/1/1e/Human_practices_hover.png";
 +
humanarray[3].src="https://static.igem.org/mediawiki/2010/d/d6/Human_practices_down.png";
 +
 
 +
notearray[1].src="https://static.igem.org/mediawiki/2010/8/8f/Notebook_none.png";
 +
notearray[2].src="https://static.igem.org/mediawiki/2010/1/18/Notebook_hover.png";
 +
notearray[3].src="https://static.igem.org/mediawiki/2010/a/a5/Notebook_down.png";
 +
 
 +
partsarray[1].src="https://static.igem.org/mediawiki/2010/5/57/Parts_none.png";
 +
partsarray[2].src="https://static.igem.org/mediawiki/2010/3/38/Parts_hover.png";
 +
partsarray[3].src="https://static.igem.org/mediawiki/2010/c/c0/Parts_down.png";
 +
 
 +
sponsarray[1].src="https://static.igem.org/mediawiki/2010/4/46/Support_none.png";
 +
sponsarray[2].src="https://static.igem.org/mediawiki/2010/2/22/Support_hover.png";
 +
sponsarray[3].src="https://static.igem.org/mediawiki/2010/8/8d/Support_down.png";
 +
 
 +
function writeText(txt)
 +
{document.getElementById("desc").innerHTML=txt; }
 +
 
 +
function swap(num,effect) {
 +
 
 +
switch (num) {
 +
 
 +
case 1: document.getElementById("pic"+num).src =modelarray[effect].src;
 +
break;
 +
case 2: document.getElementById("pic"+num).src =teamarray[effect].src;
 +
break;
 +
case 3: document.getElementById("pic"+num).src =humanarray[effect].src;
 +
break;
 +
case 4: document.getElementById("pic"+num).src =notearray[effect].src;
 +
break;
 +
case 5: document.getElementById("pic"+num).src =partsarray[effect].src;
 +
break;
 +
case 6: document.getElementById("pic"+num).src =sponsarray[effect].src;
 +
break;
}
}
 +
}
-
</style>
+
function mouseOver(num) {
 +
swap(num,2);
 +
}
-
  <body>
+
function mouseOut(num)
-
    <table border=0 cellpadding="0" cellspacing="0" style="border-style:none; border-spacing:0; vertical-align:top; margin:0px; table-layout:fixed; width:975px;">
+
{
-
<tr>
+
swap(num,1);
-
<td  id="table_header_left">
+
}
-
<table border=0 class="subtable_left">
+
 
-
<tr>
+
function mouseDown(num)
-
<td class="mainwrapper"><img src="https://static.igem.org/mediawiki/2009/d/dc/Brockhauscells.jpg" />
+
{
-
You are working in bacteria and never heard of U2-OS, SREBP or CYP1A1? Don't worry! Browse our Eukaryopedia  and enter the world of mammalian BioBricks.
+
swap(num,3);
-
</td>
+
}
-
<td class="mainwrapper"><img src="https://static.igem.org/mediawiki/2009/3/37/Heartbeat_small.gif" />
+
 
-
Our team worked on a computational approach for the rational design of promoter libraries. Similar to existing methods which predict spatial preferences of transcription factor binding sites (TFBS) by detecting statistically overrepresented motives we used Promotersweep to analyze and process the information of over 4000 human promoter sequences.
+
function mouseUp(num)
-
</td>
+
{
-
<td class="mainwrapper"><img src="https://static.igem.org/mediawiki/2009/0/06/HD09_Team_180px.png" />
+
swap(num,2);
-
Thirteen students and nine advisors are working on this four month project. We split up into several subgroups whose focus and results you can follow on the Notebook and Project pages. If you want to know more about the subgroups and the people involved, meet us on our Team page  and let's get to know each other better at the Jamboree in Boston.
+
}
-
</td>
+
 
-
</tr>
+
</script>
-
<tr>
+
</html>
-
<td class="mainwrapper"><img src="https://static.igem.org/mediawiki/2009/d/dc/Brockhauscells.jpg" />
+
{{:Team:Heidelberg/Pagetop|home}}
-
You are working in bacteria and never heard of U2-OS, SREBP or CYP1A1? Don't worry! Browse our Eukaryopedia  and enter the world of mammalian BioBricks.
+
 
-
</td>
+
<html>
-
<td class="mainwrapper"><img src="https://static.igem.org/mediawiki/2009/3/37/Heartbeat_small.gif" />
+
 
-
Our team worked on a computational approach for the rational design of promoter libraries. Similar to existing methods which predict spatial preferences of transcription factor binding sites (TFBS) by detecting statistically overrepresented motives we used Promotersweep to analyze and process the information of over 4000 human promoter sequences.
+
<div id="wrapperheadline">iGEM Heidelberg Mission 2010: miBricks</div><br><br>
-
</td>
+
 
-
<td class="mainwrapper"><img src="https://static.igem.org/mediawiki/2009/0/06/HD09_Team_180px.png" />
+
<div id="projectabstract">The key to successful gene therapy is integration of tissue specificity and fine-tuned target gene expression. iGEM Team Heidelberg 2010 unlocks the world of synthetic microRNAs. We engineered a toolkit for standardized measurements of interactions between artificial miRNAs and their binding sites. Thus, the expression level of any gene of choice could be arbitrarily adjusted by employing the corresponding binding site design. To produce tissue specific miRNA gene shuttles, we developed an evolution-based method for synthesis of new adeno associated viruses. In the future, miBricks could open the doors to new Synthetic Biology based medical approaches. </div><br><br>
-
Thirteen students and nine advisors are working on this four month project. We split up into several subgroups whose focus and results you can follow on the Notebook and Project pages. If you want to know more about the subgroups and the people involved, meet us on our Team page  and let's get to know each other better at the Jamboree in Boston.
+
 
-
</td>
+
<div id="pics">
-
</tr>
+
<a class="piclinks" onMouseOver="mouseOver(1)"  onMouseOut="mouseOut(1)" onMouseDown="mouseDown(1)" onMouseUp="mouseUp(1)" href="javascript:writeText('Modeling')">
-
</table>
+
<img id="pic1" border=0 src="https://static.igem.org/mediawiki/2010/2/2d/Modeling_none.png" />
-
</td>
+
</a>
-
<td  id="table_header_right">
+
 
-
<table border=0  class="subtable_right">
+
<a class="piclinks" href="javascript:writeText('<a href=&quot;https://2010.igem.org/Team:Heidelberg/Team&quot;>Team</a>')" onMouseOver="mouseOver(2)" onMouseOut="mouseOut(2)" onMouseDown="mouseDown(2)" onMouseUp="mouseUp(2)">
-
<tr>
+
<img id="pic2"  border=0 src="https://static.igem.org/mediawiki/2010/8/82/Team_none.png"; />
-
<td><img src="http://igem.bioquant.uni-heidelberg.de/mediawiki/images/b/bf/20100823_igemhd2010_2.jpg" width="260px"/>
+
</a>
-
</td>
+
 
-
</tr>
+
<a class="piclinks" href="javascript:writeText('Human Practices')" onMouseOver="mouseOver(3)" onMouseOut="mouseOut(3)" onMouseDown="mouseDown(3)" onMouseUp="mouseUp(3)">
-
</table>
+
<img id="pic3"  border=0 src="https://static.igem.org/mediawiki/2010/a/a7/Human_practices_none.png" />
-
</td>
+
</a>
-
</tr>
+
 
-
<tr>
+
<center><table id="desc-table"><tr><td><div id ="desc" border=0><center>Please click a Button to get more information!</center></div></td></tr></table></center>
-
<td id="table_footer_left">
+
 
-
&nbsp;
+
 
-
</td>
+
<a class="piclinks" href="javascript:writeText('Notebook')" onMouseOver="mouseOver(4) onMouseOut="mouseOut(4)" onMouseDown="mouseDown(4)" onMouseUp="mouseUp(4)">
-
<td  id="table_footer_right">&nbsp;
+
<img id="pic4" border=0 src="https://static.igem.org/mediawiki/2010/8/8f/Notebook_none.png" />
-
</td>
+
</a>
-
</tr>
+
 
-
</table>
+
<a class="piclinks" href="javascript:writeText('Parts')" onMouseOver="mouseOver(5) onMouseOut="mouseOut(5)" onMouseDown="mouseDown(5)" onMouseUp="mouseUp(5)">
 +
<img id="pic5"  border=0 src="https://static.igem.org/mediawiki/2010/5/57/Parts_none.png" />
 +
</a>
 +
 
 +
<a class="piclinks" href="javascript:writeText('Sponsors')" onMouseOver="mouseOver(6) onMouseOut="mouseOut(6)" onMouseDown="mouseDown(6)" onMouseUp="mouseUp(6)">
 +
<img id="pic6"  border=0 src="https://static.igem.org/mediawiki/2010/4/46/Support_none.png" />
 +
</a>
 +
</div>
 +
<br><br><br><br><br><br>
 +
<div class="clear"></div>
 +
<center>
 +
<img src="https://static.igem.org/mediawiki/2010/f/ff/IGEM_official_gray.png"/>
 +
</center></div>
 +
 
 +
</html>
 +
{{:Team:Heidelberg/Pagemiddle}}
 +
<html>
 +
 
 +
<br><img src="https://static.igem.org/mediawiki/2010/a/a4/Igemhd2010_2s.png" width="260px"/><br><br>
 +
<object type="application/x-shockwave-flash" data="http://www.oneplusyou.com/bb/files/countdown/countdown.swf?co=F09600&bgcolor=f2f2f2&date_month=11&date_day=05&date_year=0&un=IGEM JAMBOREE 2010&size=normal&mo=11&da=05&yr=2010" width="250" height="80"><param name="movie" value="http://www.oneplusyou.com/bb/files/countdown/countdown.swf?co=F09600&date_month=11&date_day=05&date_year=0&un=UNTIL IGEM JAMBOREE 2010&size=normal&mo=11&da=05&yr=2010" /><param name="bgcolor" value="#f2f2f2" /></object>
   </body>
   </body>
</html>
</html>
 +
 +
{{:Team:Heidelberg/Bottom}}

Latest revision as of 17:08, 18 October 2010

iGEM Heidelberg Mission 2010: miBricks


The key to successful gene therapy is integration of tissue specificity and fine-tuned target gene expression. iGEM Team Heidelberg 2010 unlocks the world of synthetic microRNAs. We engineered a toolkit for standardized measurements of interactions between artificial miRNAs and their binding sites. Thus, the expression level of any gene of choice could be arbitrarily adjusted by employing the corresponding binding site design. To produce tissue specific miRNA gene shuttles, we developed an evolution-based method for synthesis of new adeno associated viruses. In the future, miBricks could open the doors to new Synthetic Biology based medical approaches.


Please click a Button to get more information!



Retrieved from "http://2010.igem.org/User:ThomasU/main"