Team:IIT Madras

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[[Image:Iitm_logo.png|150px|right|frame|Indian Institute of Technology Madras]]
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
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On average, the world loses 2 people to cardiovascular complications every minute; Diabetes claims 4 times that number making it the 6th most common cause of death worldwide. India alone contributes 1 in every 25 of the diabetes cases every year. The World Health Organisation recently reported that up to 245 million people suffer from diabetes worldwide. It is estimated that diabetes consumes between 5 to 10% of the world's health care expenditure, and this is expected to go up to 12% in the next 20 years. There is, however, no known cure to this epidemic, and our only hope is to fall back to the old adage, 'Prevention is better than cure'. It has been known for a while that reducing the calories consumed in the form of sugar will help in the prevention of this disease, and is an essential part of living-with the disease. To date, seven different sweetening proteins have been identified and approved for consumption by the FDA. However, these proteins face several issues in production, separation and purification, making them an ideal candidate for further work, particularly focusing on expression and regulation.
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We aim to use synthetic biology to engineer pro-biotic lactic acid bacteria used in the production of dairy products like yogurt, buttermilk and curds, to produce Monellin, a heat and pH stable sweetening protein. If we are successful in engineering Lactococcus lactis, a Gram positive bacteria to express and secrete Monellin, we will be able to produce dairy products low in poly-saccharide-based sweeteners, radically reducing the calorific content of these products. In order to be able to control the level of expression in this system, we plan to develop a regulatory system(s) that can be tweaked to suit varied purposes.
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As an outcome of this effort, we hope to give Diabetes patients a fighting chance to retain a comfortable life, without compromising on their sweet-tooth. <br>
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<a href="https://igem.org/Team.cgi?year=2010&team_name=IIT_Madras Official Team Profile">Official Team Profile</a>
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On an average, the world looses 2 people to cardiovascular problems every minute; Diabetes claims 4 times that number making it the 6th most common cause of death worldwide. In addition, of these, India contributes to about 1 in 25 cases. The World Health Organisation recently reported that up to 245 million people suffered from this condition. It is estimated that diabetes consumes between 5 to 10% of the world's health care expenditure, and this is expected to go up to 12% in the next 20 years. There is however no known cure to this epidemic, and our only hope is to fall back to the old adage 'Prevention is better than cure'. It has been known for a while that reducing the calories consumed in the form of sugar will help in the prevention of this disease. To date, seven different sweet tasting proteins have been identified and approved for consumption. However these proteins are hard to produce due to problems in growing of the natural sources of these proteins and separation and purification of these proteins.
 
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We aim to use synthetic biology to engineer the pro-biotic lactic acid bacteria used to ferment milk to produce dairy products like yogurt, buttermilk and curds, to produce Monellin, a heat and pH stable sweetening protein. If we are successful in engineering Lactobacillus lactis, a gram positive bacteria, commonly used in the dairy industry to express and secrete protein Monellin to the medium, we will be able to produce sweet fermented products of milk, devoid of the polysaccharide sugar . This will radically reduce the calorific contents of these products, and may also reduce the cost of their production by eliminating one of the major ingredients, sugar. In order to be able to control the level of expression of this system, we aim to develop a regulatory system(s) that can be tweaked to suit the use.
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<h3>Sponsors</h3>
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<a href="http://www.drreddys.com/"> <img src="https://static.igem.org/mediawiki/2010/5/5a/Dr_reddy_logo.jpg" height="120px" float="left" padding-right="20px"></a>
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<a href="http://www.iitm.ac.in/icsr"> <img src="https://static.igem.org/mediawiki/2010/3/33/IITM_ICSR.jpg" height="120px" float="left"></a><br><br>
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As a result of this effort, we hope to give Diabetes patients a fighting chance to retain a comfortable life, without compromising on their sweet tooths.
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<h3>Partners</h3>
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|[[Image:IIT_Madras_team.png|right|frame|Your team picture]]
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<a href="http://www.neb.com/"> <img src="https://static.igem.org/mediawiki/2010/9/9a/NEB_logo.gif" height="120px" float="left" padding-right="20px"></a>
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<a href="http://www.labmateasia.com/"> <img src="https://static.igem.org/mediawiki/2010/e/e6/Screenshot.png" height="120px" float="left"></a><br><br>
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|align="center"|[[Team:IIT_Madras | Team Example]]
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!align="center"|[[Team:IIT_Madras|Home]]
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!align="center"|[[Team:IIT_Madras/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2010&team_name=IIT_Madras Official Team Profile]
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!align="center"|[[Team:IIT_Madras/Project|Project]]
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!align="center"|[[Team:IIT_Madras/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:IIT_Madras/Modeling|Modeling]]
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!align="center"|[[Team:IIT_Madras/Notebook|Notebook]]
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!align="center"|[[Team:IIT_Madras/Safety|Safety]]
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Latest revision as of 03:53, 28 October 2010

Indian Institute of Technology Madras

On average, the world loses 2 people to cardiovascular complications every minute; Diabetes claims 4 times that number making it the 6th most common cause of death worldwide. India alone contributes 1 in every 25 of the diabetes cases every year. The World Health Organisation recently reported that up to 245 million people suffer from diabetes worldwide. It is estimated that diabetes consumes between 5 to 10% of the world's health care expenditure, and this is expected to go up to 12% in the next 20 years. There is, however, no known cure to this epidemic, and our only hope is to fall back to the old adage, 'Prevention is better than cure'. It has been known for a while that reducing the calories consumed in the form of sugar will help in the prevention of this disease, and is an essential part of living-with the disease. To date, seven different sweetening proteins have been identified and approved for consumption by the FDA. However, these proteins face several issues in production, separation and purification, making them an ideal candidate for further work, particularly focusing on expression and regulation.

We aim to use synthetic biology to engineer pro-biotic lactic acid bacteria used in the production of dairy products like yogurt, buttermilk and curds, to produce Monellin, a heat and pH stable sweetening protein. If we are successful in engineering Lactococcus lactis, a Gram positive bacteria to express and secrete Monellin, we will be able to produce dairy products low in poly-saccharide-based sweeteners, radically reducing the calorific content of these products. In order to be able to control the level of expression in this system, we plan to develop a regulatory system(s) that can be tweaked to suit varied purposes. As an outcome of this effort, we hope to give Diabetes patients a fighting chance to retain a comfortable life, without compromising on their sweet-tooth.
Official Team Profile

Sponsors



Partners



 

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