Team:NYU

From 2010.igem.org

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|It's NYU's first year at the iGEM competition and we are all synbio noobies, but we are very confident in our project this year! Unlike most other iGEM teams, we are made up of 5 undergraduate students and only two faculty advisers.
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'' Our game plan for the international genetically engineered machine competition is to construct a yeast strain capable of independent antibody discovery. Instead of relying on antibody display that require high-throughput fluorescent screening, currently the dominant method for microbial antibody discovery, our strain will be able to select for high antibody binding without outside influence. We will accomplish this by linking the antibody library and antigen with the split ubiquitin system, which will allow the yeast cells to sense the amount of antibody::antigen complexing.
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|[[Image:NYU_team.png|right|frame|Your team picture]]
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" Basically, the single chain variable fragment (scFv) antibody will be fused to the N-terminal domain of ubiquitin (N-ub) and the target antigen will be fused to the C-terminal domain (C-ub).  When the antibody and antigen form a complex, the two domains of ubiquitin are brought together and any protein that is fused downstream of C-ub will be cleaved from the rest of the complex by a ubiquitin protease. To use this mechanism to our advantage, we will fuse the Gal4 activator protein downstream of antigen::C-ub complex. So, when the antibody binds the antigen, Gal4p will be released, translocated into the nucleus and will affect transcription of genes that confer greater cell survival in the environment (either amino acid biosynthesis or, for a control, antibiotic resistance).  
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|align="center"|[[Team:NYU | Team Example]]
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<!--- The Mission, Experiments --->
 
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!align="center"|[[Team:NYU|Home]]
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!align="center"|[[Team:NYU/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2010&team_name=NYU Official Team Profile]
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<a class="bannertoplinks" href="https://2010.igem.org/Team:NYU">Home</a>
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!align="center"|[[Team:NYU/Project|Project]]
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!align="center"|[[Team:NYU/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:NYU/Modeling|Modeling]]
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<li><a class="bannertoplinks" href="https://2010.igem.org/Team:NYU/Project">Project</a>
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!align="center"|[[Team:NYU/Notebook|Notebook]]
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!align="center"|[[Team:NYU/Safety|Safety]]
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<li><a class="bannerlinks" href="https://2010.igem.org/Team:NYU/Project">Overview</a></li>
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                        <li><a class="bannerlinks" href="https://2010.igem.org/Team:NYU/Team">NYU</a></li>
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                        <li><a class="bannerlinks" href="https://2010.igem.org/Team:NYU/CornellMed">Cornell Med</a></li>
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<h3 align="center"><a href="https://2010.igem.org/Team:NYU/Parts">Biobricks</a></h3>
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<center><a href="https://2010.igem.org/Team:NYU/Parts"><img src="https://static.igem.org/mediawiki/2010/9/97/StandardAssemblyTwoIntoOne.png" width="200" height="180" alt="biobricks" /></a></center>
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<h3 align="center"><a href="https://2010.igem.org/Team:NYU/Sponsors">Our Sponsors</a></h3>
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<h3 align="center"><a href="https://2010.igem.org/Team:NYU/Safety">Safety</a></h3>
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Latest revision as of 09:14, 27 October 2010




Biobricks

biobricks


Our Sponsors

sponsors


Notebook

notebook


The Project

project


Programming

Programming

Team

team


Safety

safety




Retrieved from "http://2010.igem.org/Team:NYU"