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Team:Newcastle/Meetings/24 February 2010
From 2010.igem.org
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*iGEM 2010 Team Newcastle Registered | *iGEM 2010 Team Newcastle Registered | ||
*Final Date for Jamboree 5-8th Nov? | *Final Date for Jamboree 5-8th Nov? | ||
| - | + | ==== Shortlist so far ==== | |
| - | + | ||
| - | ==== | + | |
'''Project ideas''' – team members assigned to look into this projects | '''Project ideas''' – team members assigned to look into this projects | ||
TOP FIVE | TOP FIVE | ||
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:[D] '''MAZef kill switch''' | :[D] '''MAZef kill switch''' | ||
| - | ==== | + | ====Decision of project==== |
*Ideal situation: All decide on one project on Friday – Present idea on Wed | *Ideal situation: All decide on one project on Friday – Present idea on Wed | ||
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*If can’t decide on which project – put it to the vote (like last year!) | *If can’t decide on which project – put it to the vote (like last year!) | ||
| - | ==== | + | ====Presentations==== |
*About 5 minutes, 3-4 slides. | *About 5 minutes, 3-4 slides. | ||
*Work in assigned groups of three | *Work in assigned groups of three | ||
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*Major Weakness of many previous iGEM teams – Modelling is tagged onto Lab work. We should perform modelling-informed lab work | *Major Weakness of many previous iGEM teams – Modelling is tagged onto Lab work. We should perform modelling-informed lab work | ||
| - | ==== | + | ====Timeline==== |
For the Summary table for AW & JH: | For the Summary table for AW & JH: | ||
*Different Individuals holidays should by included | *Different Individuals holidays should by included | ||
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*Team Roster – Finalise who is coming to the Jamboree – twice? | *Team Roster – Finalise who is coming to the Jamboree – twice? | ||
| - | ==== Action Points | + | ==== Action Points==== |
#All members to apply for membership for iGEM 2010 Team Newcastle | #All members to apply for membership for iGEM 2010 Team Newcastle | ||
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# Purchase/try Natto!!!!! | # Purchase/try Natto!!!!! | ||
| - | ====Other businesses | + | ====Other businesses==== |
*Harsh’s cheaper/quicker flight to Boston option - Booking has to go through University still. Would be helpful to identify flights | *Harsh’s cheaper/quicker flight to Boston option - Booking has to go through University still. Would be helpful to identify flights | ||
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*Chemical engineer would be required | *Chemical engineer would be required | ||
| - | =====[3]'''BactoNatto, Teeth, Coating spores/BS'''===== | + | =====[3] '''BactoNatto, Teeth, Coating spores/BS'''===== |
*S. mutans binding to ... in teeth -> decay teeth | *S. mutans binding to ... in teeth -> decay teeth | ||
*displace this organism with BS | *displace this organism with BS | ||
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*bacteria grow in a certain pattern without external stimuli - they decide on the basis of local stimuli | *bacteria grow in a certain pattern without external stimuli - they decide on the basis of local stimuli | ||
*Game of life and Rock, Paper Sissors game by [https://2009.igem.org/Team:Southampton Southampton 2009] | *Game of life and Rock, Paper Sissors game by [https://2009.igem.org/Team:Southampton Southampton 2009] | ||
| - | *See also [https://2009.igem.org/Team:Osaka | + | *See also [https://2009.igem.org/Team:Osaka Osaka 2009] |
Latest revision as of 10:09, 27 October 2010
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Contents |
Formal Meeting - 24 February 2010
- Start time: 3.10-5.35 pm
- Room 922
- Attendance
- Present: Da (Computer), Harsh, Jannetta, Rachel (Chair), Younus (Minutes), Zoltan, Richard, Steven, Anil, Jen, Matt
- Apologies: Alan, Phil
Updates
- iGEM 2010 Team Newcastle Registered
- Final Date for Jamboree 5-8th Nov?
Shortlist so far
Project ideas – team members assigned to look into this projects TOP FIVE
- [1] Computing DNA - Rachel, Zoltan, Steven
- [2] Microcracks in Concrete - Harsh, Da, Alan
- [3] BactoNatto, Teeth, Coating spores/BS - Rachel, Younus, Jannetta
- [4] Headlice - Richard, Janetta,Phil
- [5] Linearising DNA - Richard, Phil, Zoltan
Possible other projects
- [A] Diabetes - Da, Younus and Harsh
- [B] French Flag - Steven and Zoltan
- [C] Putting BS into us?/BS against disease or diseased water? - Richard
Sub-project
- [D] MAZef kill switch
Decision of project
- Ideal situation: All decide on one project on Friday – Present idea on Wed
- Likely situation: Choose top 3 projects – Present on Wed 3rd - formal meeting
- If can’t decide on which project – put it to the vote (like last year!)
Presentations
- About 5 minutes, 3-4 slides.
- Work in assigned groups of three
- demonstrate project is viable/explain how it works + problems/issues
- Start looking at a lower level i.e. which genes involved
- Start looking at modelling languages, SPML, environments?
- Use Google Scholar
- Major Weakness of many previous iGEM teams – Modelling is tagged onto Lab work. We should perform modelling-informed lab work
Timeline
For the Summary table for AW & JH:
- Different Individuals holidays should by included
- For personal and practical issues
- To get a picture of when everyone is available
- List of all tasks with hard deadlines highlighted
- T-Shirts/Poster – not a single point
- Misc?
- Team Roster – Finalise who is coming to the Jamboree – twice?
Action Points
- All members to apply for membership for iGEM 2010 Team Newcastle
- AW & JW to e-mail Jannetta and Phil about Timeline summary
- Visas/Passports – Check whether visas required/If passports in date.
- Zoltan and Harsh –
- British Passport -> don’t need visa but need to fill in online form
- JH, AW and M… already have visas from last years
- Complete Data mining
- Purchase/try Natto!!!!!
Other businesses
- Harsh’s cheaper/quicker flight to Boston option - Booking has to go through University still. Would be helpful to identify flights
Ideas
[1] Computing DNA
- Kill switch
- Modifying bacteria so that as they evolve they move closer or further away from answering a problem
- Bacteria survive if close to answer [1?], die if further away from answer [0?]
- Hamiltonian Pathway
[2] Microcracks in Concrete
- Spray bacteria into concrete
- spray nutrients, when nutrients run out – forms a polymer/biofilm
- fills cracks by producing e.g. polymer, protein, CaCO3 etc.
- Difficulty – way of detecting cracks - X-rays
- Great wall of China – used rice – still there!
- Worlds strongest Glue – Camylobacter cresentus
- Spider silk – contracts as it dries – could be like reinforced concrete
- Spores germinate when cracks get bigger – start to grow again!
- Applications: Cracks in space shuttles, shoes
- Advantage over normal glue? BS can get to cracks, where normal glue cannot!
- Well-known problem – microcracks will develop into bigger cracks
- Chemical engineer would be required
[3] BactoNatto, Teeth, Coating spores/BS
- S. mutans binding to ... in teeth -> decay teeth
- displace this organism with BS
- 90 day protection?
- Spoon of this - mix into anything?
- MIT 2007 -> didnt manage to transform lactobacillus with specific plasmid
- Would have to use a computer stimulation of teeth
- Chocolate/vanilla/banana flavoured Natto!
- Miracal cure
- with Fluorides, Omega, Vitamins [D], Minerals etc.
[4] Headlice
- Male stomach discs?
- Female symbiotic relationship with bacteria
- How to introduce BS?
- Lice v hard to get rid of
- Bacillus Stringensis?
[5] Linearising DNA
- bacteria with linear chromosomes/plasmids - Agrobacteria?
- Streptomyces ... also has linear DNA
- problem of replication - as it is normally bidirectional
- Richard's two papers
- Flipase/RecA?
[B] French Flag
- spatial and temporal organisation-self organisation
- bacteria grow in a certain pattern without external stimuli - they decide on the basis of local stimuli
- Game of life and Rock, Paper Sissors game by Southampton 2009
- See also Osaka 2009
