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| - | {{ETHZ_Basel10}}
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| - | {{ETHZ_Basel10_Start}}
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| - | = Introduction =
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| - | == Project Overview ==
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| - | <html>
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| - | <div class="center"><div class="thumb tnone"><div class="thumbinner" style="width:662px;">
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| - | <iframe title="YouTube video player" class="youtube-player" type="text/html" width="660" height="525" src="http://www.youtube.com/embed/XoWI-fxdo74" frameborder="0"></iframe>
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| - | <div class="thumbcaption"><div class="magnify"><a href="http://www.youtube.com/watch?v=XoWI-fxdo74" class="external" title="Enlarge"><img src="/wiki/skins/common/images/magnify-clip.png" width="15" height="11" alt="" /></a></div><b>Project overview of E. lemming.</b> The core idea of E. lemming is to control chemotaxis of <i>E. coli</i> by means of light! We'll realize this by hijacking and perturbing the tumbling / directed flagellar movement apparatus. By coupling directed flagellar movement regulating proteins to a novel synthetic light-sensitive spatial localization system, their activity can be controlled reversibly.</div></div></div></div>
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| - | == Molecular Mechanism ==
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| - | <html>
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| - | <div class="center"><div class="thumb tnone"><div class="thumbinner" style="width:662px;">
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| - | <iframe title="YouTube video player" class="youtube-player" type="text/html" width="660" height="525" src="http://www.youtube.com/embed/4amn63Cagd0" frameborder="0"></iframe>
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| - | <div class="thumbcaption"><div class="magnify"><a href="http://www.youtube.com/watch?v=4amn63Cagd0" class="external" title="Enlarge"><img src="/wiki/skins/common/images/magnify-clip.png" width="15" height="11" alt="" /></a></div><b>Molecular mechanism of E. lemming.</b> A light-sensitive dimerizing complex fused to this regulating proteins at a spatially fixed location is induced by light pulses and therefore localization of the two molecules can be manipulated.</div></div></div></div>
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| - | == Information Processing ==
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| - | <html>
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| - | <div class="center"><div class="thumb tnone"><div class="thumbinner" style="width:662px;">
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| - | <iframe title="YouTube video player" class="youtube-player" type="text/html" width="660" height="525" src="http://www.youtube.com/embed/F3Mshu7bGJg" frameborder="0"></iframe>
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| - | <div class="thumbcaption"><div class="magnify"><a href="http://www.youtube.com/watch?v=F3Mshu7bGJg" class="external" title="Enlarge"><img src="/wiki/skins/common/images/magnify-clip.png" width="15" height="11" alt="" /></a></div><b>Information processing principle of E. lemming.</b> Tumbling / directed flagellar movement rates are monitored by image processing algorithms, which are linked to the light-pulse generator. This means that <i>E. coli</i> tumbling is induced or suppressed simply by pressing a light switch! This synthetic network enables control of single <i>E. coli</i> cells.</div></div></div></div>
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Latest revision as of 19:20, 13 October 2010
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