Team:HKUST

From 2010.igem.org

(Difference between revisions)
Line 52: Line 52:
</div>
</div>
-
<div class="ex">
+
<div id="home">
-
<h1>Abstract</h1><p></p>
+
 
-
<hr align="left" width="600" size="3" color="#00FF00" />
+
<b>Hi folks!</b>
-
<p>The project aims at establishing an interspecies quorum sensing system in which <em>Lactobacillus plantarum/Lactobacillus sakei </em>can sense and reduce the virulence of <em>Staphylococcus aureus</em>. Many strains of <em>S. aureus</em> are the causative agents of gastroenteritis and are also responsible for the <a href="http://en.wikipedia.org/wiki/Toxic_shock_syndrome">toxic shock syndrome</a>. On the other hand, both <em>L. plantarum</em> and <em>L. sakei</em> are regarded as non-pathogenic mutualistic normal microbes. In this project, we hope to genetically engineer a <em>Lactobacillus</em> strain that can detect the presence of autoinducing peptide (AIP) released by S. aureus and thereby synthesize and secrete RNAIII inhibiting peptide (RIP) to the extracellular environment. This heptapeptide RIP with proven effectiveness to attenuate virulence of <em>S. aureus </em>can then block the pathogenecity of <em>S. aureus </em>infection. </p>
+
<p>
-
<div style="margin:10px" style="padding:10px"><img align="middle" src="http://ihome.ust.hk/~lzhu/website/QS.png" width="450" /></div>
+
Welcome to HKUST Team Wiki Page!
-
<p>Such interspecies quorum quenching system  should be viewed as blocking agent of <em>S. aureus</em> pathogenicity.  Since quorum sensing (QS) is a natural species-specific self regulating mechanism that does not  involve in bacterial growth, neither does it incur any bacteriocidal impact,  inhibition of QS should not yield a strong selective pressure for development  of resistance. Attenuation of <em>S.  aureus </em>virulence by quorum-sensing inhibitors, rather than  bactericidal or bacteriostatic drugs, is therefore a highly attractive concept for  preventive medicine particularly when many antibiotics are usually  ineffective at <em>S. aureus</em>.</p>
+
</p>
 +
<p>We are the 2010 iGEM team from the <i><b><a href="http://www.ust.hk">Hong Kong University of Science and Technology</a></b></i> (HKUST) . This is the third year for HKUST to participate in this international synthetic biology competition. Thanks to our experienced instructors, considerate advisors and every team member from our HKUST iGEM 2010 family, we enjoyed a fantastic summer working cooperatively and effectively towards our goal.
 +
</p>
 +
<p>
 +
On this Wiki page, we are presenting how we can contribute to the health and medical studies by introducing the idea of an interspecies quorum-quenching system in which non-pathogenic bacterial species could sense and reduce the virulence of another bacterial species. Application of quorum-sensing inhibitors should not yield a strong selective pressure for development of resistance, and would
 +
therefore be an attractive concept for preventive medicine.
 +
</p>
 +
<p>
 +
The logo below shows our idea: having one non-pathogenic bacterial species 'working' against another virulent species. Let's enjoy our Wiki page and see how health and medical problems might be better addressed by synthetic biology!
 +
</p>
 +
<br />
 +
<div style="margin:10px">
 +
<p style="font-size:17px" style="font-family: Georgia, 'Times New Roman', Times, serif">
 +
<b>This is our team photo below.Click to view our team page.</p>
 +
</b>
 +
<a href="https://2010.igem.org/Team:HKUST/Team">
 +
<img src="http://ihome.ust.hk/~lzhu/website/team_photo.jpg" alt="Click to view our team page" width="500px" border="2px"/>
 +
</a>
</div>
</div>
 +
</div>
</div>
</body>
</body>
</html>
</html>
<!--end-->
<!--end-->

Revision as of 14:17, 11 September 2010

Team: HKUST

Hi folks!

Welcome to HKUST Team Wiki Page!

We are the 2010 iGEM team from the Hong Kong University of Science and Technology (HKUST) . This is the third year for HKUST to participate in this international synthetic biology competition. Thanks to our experienced instructors, considerate advisors and every team member from our HKUST iGEM 2010 family, we enjoyed a fantastic summer working cooperatively and effectively towards our goal.

On this Wiki page, we are presenting how we can contribute to the health and medical studies by introducing the idea of an interspecies quorum-quenching system in which non-pathogenic bacterial species could sense and reduce the virulence of another bacterial species. Application of quorum-sensing inhibitors should not yield a strong selective pressure for development of resistance, and would therefore be an attractive concept for preventive medicine.

The logo below shows our idea: having one non-pathogenic bacterial species 'working' against another virulent species. Let's enjoy our Wiki page and see how health and medical problems might be better addressed by synthetic biology!


This is our team photo below.Click to view our team page.

Click to view our team page

Retrieved from "http://2010.igem.org/Team:HKUST"