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Team:VT-ENSIMAG/Table5
From 2010.igem.org
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If only the nucleotide sequence were screened, it would have been easy for ill-intentioned people to bypass the software: modifying the DNA sequence such as the sequence doesn't mime the dangerous one, but in having the same resulting amino-acid chain. Changing each triplet of nucleotides by a different one but coding for the same amino-acid is enough to obtain such a result. | If only the nucleotide sequence were screened, it would have been easy for ill-intentioned people to bypass the software: modifying the DNA sequence such as the sequence doesn't mime the dangerous one, but in having the same resulting amino-acid chain. Changing each triplet of nucleotides by a different one but coding for the same amino-acid is enough to obtain such a result. | ||
| - | [[Image:VTIMAG_Codon_opt.png|center]] | + | <br> |
| + | [[Image:VTIMAG_Codon_opt.png|center|350px]] | ||
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To test if our software, taking amino-acid into account, respond well to such a modification (codon optimization), we created 20 nucleotide sequence by randomly back-translated a select agent amino-acid sequence. | To test if our software, taking amino-acid into account, respond well to such a modification (codon optimization), we created 20 nucleotide sequence by randomly back-translated a select agent amino-acid sequence. | ||
Revision as of 18:31, 18 August 2010
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Degeneracy
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If only the nucleotide sequence were screened, it would have been easy for ill-intentioned people to bypass the software: modifying the DNA sequence such as the sequence doesn't mime the dangerous one, but in having the same resulting amino-acid chain. Changing each triplet of nucleotides by a different one but coding for the same amino-acid is enough to obtain such a result.
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