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Pavia and its University owe their prestige also to many important people, that, over the centuries, lived, studied and taught here. Below we show some of the personalities, in science, medicine and mathematics, that made great Pavia.

Gerolamo Cardano

He was born in Pavia , on September 24, 1501, the illegitimate child of Fazio Cardano, a mathematically gifted lawyer, who was a friend of Leonardo da Vinci.
In 1520, he entered the University of Pavia and later in Padua studied medicine. His eccentric and confrontational style did not earn him many friends and he had a difficult time finding work after his studies had ended. In 1525, Cardano repeatedly applied to the College of Physicians in Milan, but was not admitted due to his reputation and illegitimate birth.
Eventually, he managed to develop a considerable reputation as a physician and his services were highly valued at the courts. He was the first to describe typhoid fever.
Today, he is best known for his achievements in algebra. He published the solutions to the cubic and quartic equations in his 1545 book Ars Magna. The solution to one particular case of the cubic, x3 + ax = b (in modern notation), was communicated to him by Niccolò Fontana Tartaglia (who later claimed that Cardano had sworn not to reveal it, and engaged Cardano in a decade-long fight), and the quartic was solved by Cardano's student Lodovico Ferrari. Both were acknowledged in the foreword of the book, as well as in several places within its body. In his exposition, he acknowledged the existence of what are now called imaginary numbers, although he did not understand their properties (Mathematical field theory was developed centuries later). In Opus novum de proportionibus he introduced the binomial coefficients and the binomial theorem.

Cardano invented several mechanical devices including the combination lock, the gimbal consisting of three concentric rings allowing a supported compass or gyroscope to rotate freely, and the Cardan shaft with universal joints, which allows the transmission of rotary motion at various angles and is used in vehicles to this day. He studied hypocycloids, published in de proportionibus 1570. The generating circles of these hypocycloids were later named Cardano circles or cardanic circles and were used for the construction of the first high-speed printing presses. He made several contributions to hydrodynamics and held that perpetual motion is impossible, except in celestial bodies. He published two encyclopedias of natural science which contain a wide variety of inventions, facts, and occult superstitions. He also introduced the Cardan grille, a cryptographic tool, in 1550
Cardano was accused of heresy in 1570 because he had computed and published the horoscope of Jesus in 1554. Apparently, his own son contributed to the prosecution, bribed by Tartaglia. He was arrested, had to spend several months in prison and was forced to abjure his professorship. He moved to Rome, received a lifetime annuity from Pope Gregory XIII (after first having been rejected by Pope Pius V) and finished his autobiography.
He died in Rome, on September 21, 1576.

Camillo Golgi

Camillo Golgi was born in Corteno (Val Camonica), on July 7, 1843. His father was a physician and district medical officer.
Golgi studied at the University of Pavia, where he worked in the experimental pathology laboratory under Giulio Bizzozero, who elucidated the properties of bone marrow. He graduated in 1865. He spent much of his career studying the central nervous system. Tissue staining techniques in the later half of the 19th century were inadequate for studying nervous tissue. While working as chief medical officer in a psychiatric hospital, he experimented with metal impregnation of nervous tissue, using mainly silver (silver staining).
He discovered a method of staining nervous tissue which would stain a limited number of cells at random, in their entirety. This enabled him to view the paths of nerve cells in the brain for the first time. He called his discovery the "black reaction" (in Italian, reazione nera), which later received his name (Golgi's method) or Golgi stain. The reason for the random staining is still not understood.

The black reaction consisted in fixing silver chromate particles to the neurilemma (the neuron membrane) by reacting silver nitrate with potassium dichromate. This resulted in a stark black deposit on the soma as well as on the axon and all dendrites, providing an exceedingly clear and well contrasted picture of neuron against a yellow background. The ability to visualize separate neurons led to the eventual acceptance of the neuron doctrine.
In addition to this discovery, Golgi discovered a tendon sensory organ that bears his name (Golgi receptor). He studied the life cycle of Plasmodium and related the timing of tertian and quartan fevers seen in malaria with the life cycle of the organisms now named Plasmodium vivax and Plasmodium malariae, respectively. Using his staining technique, Golgi identified the intracellular reticular apparatus in 1898 which bears his name, the Golgi apparatus.
In renal physiology Golgi is renowned for being the first to show that the distal tubulus of the nephron returns to its originating glomerulus, a finding that he published in 1889.
Golgi, together with Santiago Ramón y Cajal, received the Nobel Prize in Physiology or Medicine in 1906 for his studies of the structure of the nervous system. Golgi died on Pavia, Italy, in January 1926.

Lazzaro Spallanzani

He was born in Scandiano in the modern province of Reggio Emilia, on 10 January 1729 and died in Pavia, in 12 February 1799 Italy. Spallanzani was educated at the Jesuit College and started to study law at the University of Bologna, which he gave up soon and turned to science. Here, his famous kinswoman, Laura Bassi, was professor of physics and it is to her influence that his scientific impulse has been usually attributed. With her he studied natural philosophy and mathematics, and gave also great attention to languages, both ancient and modern, but soon abandoned them.
In 1754, at the age of 25 he became professor of logic, metaphysics and Greek in the University of Reggio. In 1762 he was ordained as a priest, 1763 he was moved to Modena, where he continued to teach with great assiduity and success, but devoted his whole leisure to natural science. He declined many offers from other Italian universities and from St Petersburg until 1768, when he accepted the invitation of Maria Theresa to the chair of natural history in the University of Pavia, which was then being reorganized. He also became director of the museum, which he greatly enriched by the collections of his many journeys along the shores of the Mediterranean Sea. In 1775, Spallanzani was elected a foreign member of the Royal Swedish Academy of Sciences.

Spallanzani was a Catholic who researched the theory about the spontaneous generation of cellular life in 1768. His experiment suggested that microbes move through the air and that they could be killed through boiling. Critics of Spallazani's work argued his experiments destroyed the "life force" that was required for spontaneous generation to occur. His work paved the way for later research by Louis Pasteur, who defeated the theory of spontaneous generation.
He also discovered and described animal (mammal) reproduction, showing that it requires both semen and an ovum. He was the first to perform in vitro fertilization, with frogs, and an artificial insemination, using a dog. Spallanzani showed that some animals, especially newts, can regenerate some parts of their body if injured or surgically removed.
Spallanzani is also famous for extensive experiments on the navigation in complete darkness by bats, where he concluded that bats use sound and their ears for navigation in total darkness(see animal echolocation). He was the pioneer of the original study of echolocation, though his study was limited to what he could observe. Later scientists moved onto studies of the sensory mechanisms and processing of this information.
His great work, however, is the Dissertationi di fisica animale e vegetale (2 vols, 1780). Here he first interpreted the process of digestion, which he proved to be no mere mechanical process of trituration - that is, of grinding up the food - but one of actual chemical solution, taking place primarily in the stomach, by the action of the gastric juice. He also carried out important researches on fertilization in animals (1780).
He died from bladder cancer on the 27th of February 1799, in Pavia. After his death, his bladder was removed for study by his colleagues, after which it was placed on public display in a museum in Pavia, Italy, where it remains to this day.

Alessandro Volta

Volta was born in Como, Italy, 18 February, 1745, and taught in the public schools there. In 1774 he became a professor of physics at the Royal School in Como. A year later, he improved and popularized the electrophorus, a device that produces a static electric charge.
In 1776-77 Volta studied the chemistry of gases. He discovered methane by collecting the gas from marshes. He devised experiments such as the ignition of methane by an electric spark in a closed vessel. Volta also studied what we now call electrical capacitance, developing separate means to study both electrical potential (V) and charge (Q), and discovering that for a given object they are proportional. This may be called Volta's Law of capacitance, and likely for this work the unit of electrical potential has been named the Volt.

In 1779 he became professor of experimental physics at the University of Pavia, a chair he occupied for almost 25 years.
In 1800, as the result of a professional disagreement over the galvanic response advocated by Galvani, he invented the voltaic pile, an early electric battery, which produced a steady electric current. Volta had determined that the most effective pair of dissimilar metals to produce electricity was zinc and silver. Initially he experimented with individual cells in series, each cell being a wine goblet filled with brine into which the two dissimilar electrodes were dipped. The voltaic pile replaced the goblets with cardboard soaked in brine.
In honor of his work, Volta was made a count by Napoleon in 1810.
Furthermore, he was depicted upon the Italian 10,000 Lire (no longer in circulation) along with a sketch of his famous Voltaic Pile.
Volta retired in 1819 in his estate in Camnago, a frazione of Como now called Camnago Volta after him, where he died on March 5, 1827.

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