Team:Northwestern/Safety

From 2010.igem.org

(Difference between revisions)
(Prototype team page)
(Safety)
 
(38 intermediate revisions not shown)
Line 1: Line 1:
-
<!-- *** What falls between these lines is the Alert Box!  You can remove it from your pages once you have read and understood the alert *** -->
+
__NOTOC__
 +
 
<html>
<html>
-
<div id="box" style="width: 700px; margin-left: 137px; padding: 5px; border: 3px solid #000; background-color: #fe2b33;">
+
<style>
-
<div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
+
/* Wiki Hacks - START */
-
This is a template page. READ THESE INSTRUCTIONS.
+
#globalWrapper {
-
</div>
+
    background-color: transparent;
-
<div id="instructions" style="text-align: center; font-weight: normal; font-size: small; color: #f6f6f6; padding: 5px;">
+
    padding-bottom:0px;
-
You are provided with this team page template with which to start the iGEM seasonYou may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
+
    border: none;
-
</div>
+
    }
-
<div id="warning" style="text-align: center; font-weight: bold; font-size: small; color: #f6f6f6; padding: 5px;">
+
#top-section {
-
You <strong>MUST</strong> have a team description page, a project abstract, a complete project description, a lab notebook, and a safety page.  PLEASE keep all of your pages within your teams namespace. 
+
    height: 0px;
-
</div>
+
    margin-top: 0px;
-
</div>
+
    margin-left: auto;
 +
    margin-right: auto;
 +
    margin-bottom: 0 !important;
 +
    margin-bottom: 0px;
 +
    padding:0;
 +
    border: 1;
 +
    }
 +
#p-logo {
 +
    height:0px;
 +
    overflow:hidden;
 +
    border:none;
 +
    }
 +
#search-controls {
 +
    overflow:hidden;
 +
    display:none;
 +
    background: none;
 +
    position: absolute;
 +
    top: 100px;
 +
    right: 40px;
 +
    }         
 +
 
 +
 
 +
/* Wiki Hacks - END */
 +
 
 +
 
 +
#content {
 +
    background-color: transparent;
 +
    width:99%;
 +
    position: relative;
 +
    float: center;
 +
    border: 0px;
 +
}
 +
 
 +
#menubar {
 +
background-color:transparent;
 +
font-size:85%;
 +
line-height:1em;
 +
position:absolute;
 +
top:10px;
 +
white-space:nowrap;
 +
width:50%;
 +
z-index:5;
 +
height:25px;
 +
overflow:hidden;
 +
}
 +
 
 +
#menubar li a {
 +
color:#000000;
 +
}
 +
 
 +
.left-menu {
 +
left:0;
 +
padding-left:13px;
 +
}
 +
.right-menu {
 +
right:0;
 +
}
 +
 
 +
.firstHeading { display:none; }
 +
}
 +
 
 +
 
 +
 
 +
 
 +
#footer-box {
 +
background-color: transparent;
 +
color: #000000;
 +
border: 0px;
 +
margin:0 auto;
 +
padding:13px 5px;
 +
width:auto;
 +
margin-top:-1px;
 +
}
 +
 
 +
#footer-box a {
 +
        background-color: transparent;
 +
color: #000000;
 +
font-size:90%;
 +
 
 +
}
 +
/* Wiki Hacks - END */
 +
</style>
</html>
</html>
-
<!-- *** End of the alert box *** -->
+
<html>
 +
<head>
 +
<style>
 +
body {
 +
  background: #EFCDF8; <!-- EEDCC8 url(https://static.igem.org/mediawiki/2010/3/38/BG1.jpg) repeat-y; -->
 +
}
 +
</style>
 +
</head>
 +
</html>
 +
[[Image:LOGOBANNER1.jpg|936px|center|link=http://wikipedia.org|Tech Institute]]
 +
<!--- The Mission, Experiments --->
 +
{|- style="font-size: 87%; background: #EFCDF8; color: #FFFFFF" cellpadding="1" cellspacing="1" bordercolor="#000000" width="75%" align="center"
 +
!align="center"|[[Team:Northwestern|<font color="#2B3856">'''Home'''</font>]]
 +
!align="center"|[[Team:Northwestern/Brainstorm|<font color="#000000">'''Brainstorm'''</font>]]
 +
!align="center"|[[Team:Northwestern/Team|<font color="#000000">'''Team'''</font>]]
 +
!align="center"|[[Team:Northwestern/Acknowledgements|<font color="#000000">'''Acknowledgements'''</font>]]
 +
!align="center"|[[Team:Northwestern/Project|<font color="#000000">'''Project'''</font>]]
 +
!align="center"|[[Team:Northwestern/SideProject|<font color="#000000">'''Human Practices'''</font>]]
 +
!align="center"|[[Team:Northwestern/Parts|<font color="#000000">'''Parts'''</font>]]
 +
!align="center"|[[Team:Northwestern/Notebook|<font color="#000000">'''Notebook'''</font>]]
 +
!align="center"|[[Team:Northwestern/Calendar|<font color="#000000">'''Calendar'''</font>]]
 +
!align="center"|[[Team:Northwestern/Protocol|<font color="#000000">'''Protocol'''</font>]]
 +
!align="center"|[[Team:Northwestern/Safety|<font color="#000000">'''Safety'''</font>]]
 +
!align="center"|[[Team:Northwestern/Links|<font color="#000000">'''Links'''</font>]]
 +
!align="center"|[[Team:Northwestern/References|<font color="#000000">'''References'''</font>]]
 +
!align="center"|[[Team:Northwestern/Media|<font color="#000000">'''Media'''</font>]]
 +
!align="center"|[[Team:Northwestern/Contact|<font color="#000000">'''Contact'''</font>]]
 +
|}
-
{|align="justify"
+
{| align="center" border="0" width="75%"
-
|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
+
-
|[[Image:Northwestern_logo.png|200px|right|frame]]
+
-
|-
+
|
|
-
''Tell us more about your project.  Give us background.  Use this is the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
+
=='''Safety'''==
-
|[[Image:Northwestern_team.png|right|frame|Your team picture]]
+
-
|-
+
-
|
+
-
|align="center"|[[Team:Northwestern | Team Example]]
+
-
|}
+
-
<!--- The Mission, Experiments --->
+
Please use this page to answer the safety questions posed on the [[Safety | safety page]].
-
{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
+
  1.  '''Would any of your project ideas raise safety issues in terms of:'''
-
!align="center"|[[Team:Northwestern|Home]]
+
          * researcher safety,
-
!align="center"|[[Team:Northwestern/Team|Team]]
+
          * public safety, or
-
!align="center"|[https://igem.org/Team.cgi?year=2010&team_name=Northwestern Official Team Profile]
+
          * environmental safety?
-
!align="center"|[[Team:Northwestern/Project|Project]]
+
  2. '''Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues? If yes,'''
-
!align="center"|[[Team:Northwestern/Parts|Parts Submitted to the Registry]]
+
          * did you document these issues in the Registry?
-
!align="center"|[[Team:Northwestern/Modeling|Modeling]]
+
          * how did you manage to handle the safety issue?
-
!align="center"|[[Team:Northwestern/Notebook|Notebook]]
+
          * How could other teams learn from your experience?
-
!align="center"|[[Team:Northwestern/Safety|Safety]]
+
  3. '''Is there a local biosafety group, committee, or review board at your institution?'''
-
|}
+
          * If yes, what does your local biosafety group think about your project?
 +
          * If no, which specific biosafety rules or guidelines do you have to consider in your country?
 +
  4. '''Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions?'''
 +
      '''How could parts, devices and systems be made even safer through biosafety engineering?'''
-
==Safety==
+
1. '''Would any of your project ideas raise safety issues in terms of researcher safety, public safety or environmental safety?'''<br />
-
Please use this page to answer the safety questions posed on the [[Safety | safety page]].
+
We can pinpoint three possible negative consequences of our project:
 +
 
 +
1. The strain produces some toxin related to chitin in addition to the chitin itself.<br>
 +
2. The strain produces pure chitin, and the extraction thereof results in a high incidence of allergic reaction    among those that work with it.<br>
 +
3. The strain becomes airborne, resulting in lung infection and chitin deposition in the airways.<br>
 +
 
 +
 
 +
2. '''Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues?'''<br />
 +
 
 +
No, our newly constructed parts and devices fit the iGEM safety  requirements.
 +
 
 +
3. '''Is there a local biosafety group, committee, or review board at your institution?'''<br />
 +
 
 +
Yes, the Northwestern University Office for Research Safety (ORS) and the Northwestern University Institutional Biosafety Committee (IBC) proactively work to ensure ethical research practices for the safety of both researchers and participants.
 +
 
 +
'''If yes, what does your local biosafety group think about your project?'''<br />
 +
 
 +
Our project is subject to standard laboratory regulations for general safety and recombinant DNA work.
 +
 
 +
Had we sought review outside of Dr. Mordacq's IBC approval, we would need to address the three concerns listed above in more detail, such as what would occur if a researcher ingested, injected, or inhaled our recombinant strain.
 +
 
 +
4. '''Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions?'''<br />
 +
 
 +
When pursuing a project, an iGEM team should attempt to think ahead of any dangerous consequences of their pursuits.  If there are any concerns, the team should consider drafting recommendations for any group that might desire to utilize their devices.  If infection is a concern, appropriate apoptotic signals should be considered.
 +
 
 +
'''How could parts, devices and systems be made even safer through biosafety engineering?'''
 +
 
 +
Parts might be programmed with an apoptotic signal so that the bacteria dies when separated from culture.  In addition, certain "key" systems may be desirable.  If parts provided are of a somewhat "black box" format, it may be possible to program in killswitches so that if a strain is not treated with a particular nutrient or other molecule, transformed strains either apoptose or do not have the proper function.  If these keys are sent with the desired part, it may make it more difficult to "hack" dangerous parts for illicit use.
 +
 
 +
 
 +
|}

Latest revision as of 20:44, 27 October 2010


Tech Institute
Home Brainstorm Team Acknowledgements Project Human Practices Parts Notebook Calendar Protocol Safety Links References Media Contact

Safety

Please use this page to answer the safety questions posed on the safety page.

  1.  Would any of your project ideas raise safety issues in terms of:
         * researcher safety,
         * public safety, or
         * environmental safety?
  2. Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues? If yes,
         * did you document these issues in the Registry?
         * how did you manage to handle the safety issue?
         * How could other teams learn from your experience?
  3. Is there a local biosafety group, committee, or review board at your institution?
         * If yes, what does your local biosafety group think about your project?
         * If no, which specific biosafety rules or guidelines do you have to consider in your country?
  4. Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions?
     How could parts, devices and systems be made even safer through biosafety engineering?


1. Would any of your project ideas raise safety issues in terms of researcher safety, public safety or environmental safety?

We can pinpoint three possible negative consequences of our project:

1. The strain produces some toxin related to chitin in addition to the chitin itself.
2. The strain produces pure chitin, and the extraction thereof results in a high incidence of allergic reaction among those that work with it.
3. The strain becomes airborne, resulting in lung infection and chitin deposition in the airways.


2. Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues?

No, our newly constructed parts and devices fit the iGEM safety requirements.

3. Is there a local biosafety group, committee, or review board at your institution?

Yes, the Northwestern University Office for Research Safety (ORS) and the Northwestern University Institutional Biosafety Committee (IBC) proactively work to ensure ethical research practices for the safety of both researchers and participants.

If yes, what does your local biosafety group think about your project?

Our project is subject to standard laboratory regulations for general safety and recombinant DNA work.

Had we sought review outside of Dr. Mordacq's IBC approval, we would need to address the three concerns listed above in more detail, such as what would occur if a researcher ingested, injected, or inhaled our recombinant strain.

4. Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions?

When pursuing a project, an iGEM team should attempt to think ahead of any dangerous consequences of their pursuits. If there are any concerns, the team should consider drafting recommendations for any group that might desire to utilize their devices. If infection is a concern, appropriate apoptotic signals should be considered.

How could parts, devices and systems be made even safer through biosafety engineering?

Parts might be programmed with an apoptotic signal so that the bacteria dies when separated from culture. In addition, certain "key" systems may be desirable. If parts provided are of a somewhat "black box" format, it may be possible to program in killswitches so that if a strain is not treated with a particular nutrient or other molecule, transformed strains either apoptose or do not have the proper function. If these keys are sent with the desired part, it may make it more difficult to "hack" dangerous parts for illicit use.