Team:HKUST

From 2010.igem.org

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<li><a href="http://ihome.ust.hk/~lzhu/website/index.html">Home</a></li>
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<b>Hi folks!</b>
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    <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">Team</a></li>
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    <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">Project</a></li>
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Welcome to HKUST Team Wiki Page!
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    <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">Lab Notebook</a></li>
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    <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">Gallery</a></li>
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<p>We are the 2010 iGEM team from the <i><b><a href="http://www.ust.hk">Hong Kong University of Science and Technology</a></b></i> (HKUST) . This is the third year for HKUST to participate in this international synthetic biology competition.  
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On this Wiki page, we are presenting how synthetic biology could contribute to health and medical studies. We are here introducing an idea – an interspecies quorum-quenching system in which non-pathogenic <i>Lactobacillus</i> could sense and reduce the virulence of <i>Staphylococcus aureus</i>. Such a model system should not yield a strong selective pressure for development of resistance, and would
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therefore be an attractive concept for preventive medicine.<i><a href="https://2010.igem.org/Team:HKUST/Project">Click here to read more about our project</a></i>
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Thanks to our experienced instructors, considerate advisors and every team member from HKUST iGEM 2010 family, we enjoyed a fantastic summer working cooperatively and effectively towards our goal. The logo below demonstrates our project idea: having non-pathogenic <i>Lactobacillus</i> (left) ‘working’ against virulent <i>S. aureus</i> (right):
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<div style="text-align:center"><img src="https://static.igem.org/mediawiki/2010/9/9e/HKUST_Logo.png" alt="Our team logo" width="200px" border="2px"/>
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Let’s now enjoy our Wiki page and see how health and medical issues might be better addressed by synthetic biology!
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<p> <a href="https://2010.igem.org/Team:HKUST/Accomplishment"><b>Click Here to View Our Accomplishment page.</b></a></p>
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<b>This is our team photo.Click to view our team page.</p>
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        <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">Here we are!</a></h3></li>
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<img src="https://static.igem.org/mediawiki/2010/b/b4/HKUST_team.png" alt="Click to view our team page" width="500px" border="2px"/></div>
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<li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">Group 1</a></li>
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<li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">June</a></li>
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        <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">July</a></li>
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        <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">August</a></li>
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        <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">September</a></li>
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        <li><a href="http://ihome.ust.hk/~lzhu/website/under%20constuct.html">Workshop</a></li>
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<h1>Abstract</h1><p></p>
 
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<p>The project aims at establishing an interspecies quorum sensing system in which <em>Lactobacillus plantarum/Lactobacillus sakei </em>can sense and reduce the virulence of <em>Staphylococcus aureus</em>. Many strains of <em>S. aureus</em> are the causative agents of gastroenteritis and are also responsible for the <a href="http://en.wikipedia.org/wiki/Toxic_shock_syndrome">toxic shock syndrome</a>. On the other hand, both <em>L. plantarum</em> and <em>L. sakei</em> are regarded as non-pathogenic mutualistic normal microbes. In this project, we hope to genetically engineer a <em>Lactobacillus</em> strain that can detect the presence of autoinducing peptide (AIP) released by S. aureus and thereby synthesize and secrete RNAIII inhibiting peptide (RIP) to the extracellular environment. This heptapeptide RIP with proven effectiveness to attenuate virulence of <em>S. aureus </em>can then block the pathogenecity of <em>S. aureus </em>infection. </p>
 
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<p>Such interspecies quorum quenching system  should be viewed as blocking agent of <em>S. aureus</em> pathogenicity.  Since quorum sensing (QS) is a  natural species-specific self regulating mechanism that does not  involve in bacterial growth, neither does it incur any bacteriocidal impact,  inhibition of QS should not yield a strong selective pressure for development  of resistance. Attenuation of <em>S.  aureus </em>virulence by quorum-sensing inhibitors, rather than  bactericidal or bacteriostatic drugs, is therefore a highly attractive concept for  preventive medicine particularly when many antibiotics are usually  ineffective at <em>S. aureus</em>.</p>
 
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Latest revision as of 15:19, 26 October 2010

Team: HKUST

Hi folks!

Welcome to HKUST Team Wiki Page!

We are the 2010 iGEM team from the Hong Kong University of Science and Technology (HKUST) . This is the third year for HKUST to participate in this international synthetic biology competition.

On this Wiki page, we are presenting how synthetic biology could contribute to health and medical studies. We are here introducing an idea – an interspecies quorum-quenching system in which non-pathogenic Lactobacillus could sense and reduce the virulence of Staphylococcus aureus. Such a model system should not yield a strong selective pressure for development of resistance, and would therefore be an attractive concept for preventive medicine.Click here to read more about our project

Thanks to our experienced instructors, considerate advisors and every team member from HKUST iGEM 2010 family, we enjoyed a fantastic summer working cooperatively and effectively towards our goal. The logo below demonstrates our project idea: having non-pathogenic Lactobacillus (left) ‘working’ against virulent S. aureus (right):

Our team logo

Let’s now enjoy our Wiki page and see how health and medical issues might be better addressed by synthetic biology!


Click Here to View Our Accomplishment page.

This is our team photo.Click to view our team page.

Retrieved from "http://2010.igem.org/Team:HKUST"