"
User:MayaBrandi/1 July 2010
From 2010.igem.org
Revision as of 07:41, 2 July 2010 by Hassanforoughiasl (Talk | contribs)
1 Microarrays - reliability - How reliable is the protein regulation profile in the article "Transcriptional profiling of melanocytes..."
2 How should one priorate different types of protein-protein interactions? Focus on experimental (not predictive ) data and focus first of all at physical PPI second at co expression and co localisation. Skip the rest.
To improve PPI reliability
- Find a good coverage from many primary databases. -How many and with?
- What experiments were used? If the same result is dereved from many different experiments then the PPI is more reliable.
- Look at 3D structures...?
Compare with canonical pathways to get a better insight in the functional roles of the proteins in the network.
