Latest revision as of 20:37, 25 October 2010

Mutant Data Table

Mutant Name	Features and Mutations	Transpeptidation per DCP	Hydrolysis per DCP
CapD	No Signal Sequence, Triple band on protein agarose gel	0.491	0.713
CapD_CP	Foldit created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	1.000	1.000
CapD_CPNFDelta	Foldit created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel, Removed "floppy" section to compact protein	1.035	0.878
F24A	Point mutation at residue 24 on CapDCP from Phenylalanine to Alanine, Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.021	0.061
F24H	Point mutation at residue 24 on CapDCP from Phenylalanine to Histidine, Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.108	1.205
F24H, L40R, T59D_M61S	Point mutation at residues 24, 40, 59, and 61 on Foldit design from Phenylalanine to Histidine, Leucine to Arginine, Threonine to Asparagine, and Methionine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.001	0.006
F24H, L40R, T59N_M61S	Point mutation at residues 24, 40, 59, and 61 on Foldit design from Phenylalanine to Histidine, Leucine to Arginine, Threonine to Aspartic Acid, and Methionine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.058	1.050
F24H, L40R, T59S_M61S	Point mutation at residues 24, 40, 59, and 61 on CapDCP from Phenylalanine to Histidine, Leucine to Arginine, Threonine to Serine, and Methionine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.000	0.007
F24H, R356K	Point mutation at residues 24 and 356 on CapDCP from Phenylalanine to Histidine and Arginine to Lysine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.129	0.257
F24H, T59R	Point mutation at residues 24 and 59 on CapDCPfrom Phenylalanine to Histidine and Threonine to Arginine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.011	0.005
F24H,T59N	Point mutation at residues 24 and 59 on CapDCP from Phenylalanine to Histidine and Threonine to Asparagine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.007	0.029
F24W	Point mutation at residue 24 on CapDCP from Phenylalanine to Tryptophan. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.006	0.044
F24Y	Point mutation at residue 24 on CapDCP from Phenylalanine to Tyrosine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.593	0.887
F24Y, L40R	Point mutation at residues 24 and 40 on CapDCP from Phenylalanine to Tyrosine and Leucine to Arginine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.009	-0.013
F24Y, L40R, T59N	Point mutation at residues 24, 40, 59 on CapDCP from Phenylalanine to Tyrosine, Leucine to Arginine, and Threonine to Asparagine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.003	0.157
F24Y,R305K	Point mutation at residues 24 and 305 on CapDCP from Phenylalanine to Tyrosine and Arginine to Lysine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.002	0.233
F24Y,T59N	Point mutation at residues 24 and 59 on CapDCP from Phenylalanine to Tyrosine and Threonine to Asparagine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.008	0.165
F24Y,T59N,R305K	Point mutation at residues 24, 59, and 356 on CapDCP from Phenylalanine to Tyrosine, Threonine to Asparagine, and Arginine to Lysine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.002	0.127
F60W	Point mutation at residue 60 on CapDCP from Phenylalanine to Tryptophan. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.239	0.489
G79A	Point mutation at residue 79 on CapDCP from Glycine to Alanine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.040	-0.511
I83T	Point mutation at residue 83 on CapDCP from Isoleucine to Threonine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.009	0.006
I83V	Point mutation at residue 83 on CapDCP from Isoleucine to Valine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.003	0.043
L40A	Point mutation at residue 40 on CapDCP from Leucine to Alanine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.150	0.413
L40R	Point mutation at residue 40 on CapDCP from Leucine to Arginine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	1.157	1.527
L40S	Point mutation at residue 40 on CapDCP from Leucine to Serine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.166	0.577
L40W	Point mutation at residue 40 on CapDCP from Leucine to Tryptophan. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.825	1.215
M61H	Point mutation at residue 61 on CapDCP from Methionine to Histidine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	-0.003	0.002
M61N	Point mutation at residue 61 on CapDCP from Methionine to Asparagine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.011	0.002
M61S	Point mutation at residue 61 on CapDCP from Methionine to Serine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.262	0.485
N23K	Point mutation at residue 23 on CapDCP from Asparagine to Lysine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.818	0.839
N23Q	Point mutation at residue 23 on CapDCP from Asparagine to Glutamine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.165	0.646
S143K	Point mutation at residue 143 on CapDCP from Serine to Lysine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.574	0.426
S22I, T59A	Point mutation at residues 22 and 59 on CapDCP from Serine to Isoleucine and Threonine to Alanine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.030	-0.057
S22Q, T59Q	Point mutation at residues 22 and 59 on CapDCP from Serine to Glutamine and Threonine to Glutamine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	-0.012	0.085
S57H, M61H	Point mutation at residues 57 and 61 on CapDCP from Serine to Histidine and Methionine to Histidine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	-0.004	-0.007
T18L, T59Q, M61N, F452W	Point mutation at residues 18, 59, 61, and 452 on CapDCP from Threonine to Leucine, Threonine to Glutamine, Methionine to Asparagine, and Phenylalanine to Tryptophan, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.020	-0.028
T18S_T20S	Point mutation at residues 18 and 20 on CapDCP from Threonine to Serine and Threonine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.617	1.186
T20A	Point mutation at residue 20 on CapDCP from Threonine to Alanine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.011	0.021
T20C	Point mutation at residue 20 on CapDCP from Threonine to Cystine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.090	0.142
T20S	Point mutation at residue 20 on CapDCP from Threonine to Serine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.639	1.443
T20S, L40D	Point mutation at residues 20 and 40 on CapDCP from Threonine to Serine and Leucine to Asparagine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.853	0.001
T20S, L40E	Point mutation at residues 20 and 40 on CapDCP from Threonine to Serine and Leucine to Glutamic Acid, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.163	0.637
T20S, L40F	Point mutation at residues 20 and 40 on CapDCP from Threonine to Serine and Leucine to Phenylalanine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.246	0.335
T20S, L40H	Point mutation at residues 20 and 40 on CapDCP from Threonine to Serine and Leucine to Histidine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.001	0.012
T20S, L40K	Point mutation at residues 20 and 40 on CapDCP from Threonine to Serine and Leucine to Lysine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.000	0.007
T20S, L40Q	Point mutation at residues 20 and 40 on CapDCP from Threonine to Serine and Leucine to Glutamine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.126	0.478
T20S, L40R	Point mutation at residues 20 and 40 on CapDCP from Threonine to Serine and Leucine to Arginine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.000	0.009
T20S, L40R, F60E	Point mutation at residues 20, 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and Phenylalanine to Glutamic Acid, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.048	0.028
T20S, L40R, F60Q	Point mutation at residues 20, 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and Phenylalanine to Glutamine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.002	0.007
T20S, L40R, N81E	Point mutation at residues 20, 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and Phenylalanine to Glutamine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.001	-0.004
T20S, L40R, N81Q	Point mutation at residues 20, 40, and 81 on CapDCP from Threonine to Serine, Leucine to Arginine, and Asparagine to Glutamine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.422	0.321
T20S, L40R, T59K	Point mutation at residues 20, 40, and 59 on CapDCP from Threonine to Serine, Leucine to Arginine, and Threonine to Lysine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.048	0.033
T20S, L40R, T59K_M61S	Point mutation at residues 20, 40, 59, and 61 on CapDCP from Threonine to Serine, Leucine to Arginine, Threonine to Lysine, and Methionine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.010	0.032
T20S, T59Q, M61T	Point mutation at residues 20, 59, and 61 on CapDCP from Threonine to Serine, Threonine to Glutamine, and Methionine to Threonine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.007	-0.069
T20S,M61A	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Alanine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.005	0.045
T20S,M61C	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Cystine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.102	0.207
T20S,M61D	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Aspartic Acid, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.004	0.003
T20S,M61G	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Glycine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.004	0.029
T20S,M61L	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Leucine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.004	0.029
T20S,M61N	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Asparagine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.003	0.002
T20S,M61S	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.007	0.053
T20S,M61T	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Threonine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.038	0.363
T20S,M61V	Point mutation at residues 20 and 61 on CapDCP from Threonine to Serine and Methionine to Valine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.004	0.039
T20S,T59N	Point mutation at residues 20 and 59 on CapDCP from Threonine to Serine and Threonine to Asparagine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.019	0.125
T20S,T59S_M61S	Point mutation at residues 20, 59, and 61 on CapDCP from Threonine to Serine, Threonine to Serine, and Methionine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.300	0.719
T20S_F24H	Point mutation at residues 20 and 24 on CapDCP from Threonine to Serine and Phenylalanine to Histidine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.008	0.097
T20S_F24Y	Point mutation at residues 20 and 24 on CapDCP from Threonine to Serine and Phenylalanine to Tyrosine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.040	0.201
T20S_F24Y,T59N	Point mutation at residues 20, 24, and 59 on CapDCP from Threonine to Serine, Phenylalanine to Tyrosine, and Threonine to Asparagine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.013	0.048
T2A	Point mutation at residue 2 on CapDCP from Threonine to Alanine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.007	-0.020
T2C	Point mutation at residue 2 on CapDCP from Threonine to Cystine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.001	-0.005
T2S	Point mutation at residue 2 on CapDCP from Threonine to Serine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.024	0.325
T2S,T18S_T20S	Point mutation at residues 2, 18, and 20 on CapDCP from Threonine to Serine, Threonine to Serine, and Threonine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.144	0.250
T2S,T18S_T20S,T59S_M61S	Point mutation at residues 2, 18, 20, 59, and 61 on CapDCP from Threonine to Serine, Threonine to Serine, Threonine to Serine, Threonine to Serine and Threonine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.003	0.022
T2S,T20S	Point mutation at residues 2 and 20 on CapDCP from Threonine to Serine and Threonine to Serine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.106	0.089
T2V	Point mutation at residue 2 on CapDCP from Threonine to Valine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.000	0.000
T59H_M61A	Point mutation at residues 59 and 61 on CapDCP from Threonine to Histidine and Methionine to Alanine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.000	0.000
T59H_M61T	Point mutation at residues 59 and 61 on CapDCP from Threonine to Histidine and Methionine to Threonine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.000	0.000
T59M	Point mutation at residue 59 on CapDCP from Threonine to Methionine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.008	0.008
T59N	Point mutation at residue 59 on CapDCP from Threonine to Asparagine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.232	0.868
T59Q	Point mutation at residue 59 on CapDCP from Threonine to Glutamine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.000	0.000
T59Q, M61Q, F452W	Point mutation at residues 59, 61, and 452 on CapDCP from Threonine to Glutamine, Threonine to Glutamine, and Phenylalanine to Tryptophan, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	-0.014	0.037
T59S	Point mutation at residue 59 on CapDCP from Threonine to Serine. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	3.525	1.047
T59S, M61H	Point mutation at residues 59 and 61 on CapDCP from Threonine to Serine and Methionine to Histidine, respectively. Foldit-created linker, Circular Permutation, No Signal Sequence, Single band on protein agarose gel	0.013	0.051

← Back to Testing the Gram(+) Therapeutic

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 .xl6413667
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 font-style:normal'>Mutant Data Table</h1>
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    <td height=26 class=xl7013667 width=172 style='height:20.1pt;width:129pt'>Mutant
    Name</td>
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    <td class=xl7013667 width=297 style='width:223pt'>Features and Mutations</td>
    <td class=xl6613667 width=168 style='width:126pt'>Transpeptidation per DCP</td>
@@ Line 200: / Line 209: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>CapD</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A protein native to <font
-  class="font613667">Bacillus anthracis </font><font class="font013667">which
-  cleaves poly-D-&#947;-glutamate (PDGA) and anchors it to the bacterium's
-  peptidoglycan</font></td>
    <td class=xl6513667 width=297 style='width:223pt'>No Signal Sequence, Triple
    band on protein agarose gel</td>
@@ Line 211: / Line 216: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>CapD_CP</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A circularly permuted CapD
-  with a Foldit-designed linker</td>
    <td class=xl6513667 width=297 style='width:223pt'>Foldit created linker,
    Circular Permutation, No Signal Sequence, Single band on protein agarose gel</td>
@@ Line 220: / Line 223: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>CapD_CPNFDelta</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A circularly permuted CapD
-  with deletion of floppy areas</td>
    <td class=xl6513667 width=297 style='width:223pt'>Foldit created linker,
    Circular Permutation, No Signal Sequence, Single band on protein agarose gel,
@@ Line 230: / Line 231: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>F24A</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Phenylalanine to Alanine, Foldit-created linker, Circular
@@ Line 241: / Line 239: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F24H</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Phenylalanine to Histidine, Foldit-created linker, Circular
@@ Line 253: / Line 248: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F24H,
    L40R, T59D_M61S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, 59, and 61 on Foldit design from Phenylalanine to Histidine, Leucine
@@ Line 267: / Line 259: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F24H,
    L40R, T59N_M61S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, 59, and 61 on Foldit design from Phenylalanine to Histidine, Leucine
@@ Line 281: / Line 270: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F24H,
    L40R, T59S_M61S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, 59, and 61 on CapDCP from Phenylalanine to Histidine, Leucine to
@@ Line 295: / Line 281: @@
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>F24H,
    R356K</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 356 on CapDCP from Phenylalanine to Histidine and Arginine to Lysine,
@@ Line 308: / Line 291: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F24H,
    T59R</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 59 on CapDCPfrom Phenylalanine to Histidine and Threonine to Arginine,
@@ Line 320: / Line 300: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>F24H,T59N</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 59 on CapDCP from Phenylalanine to Histidine and Threonine to
@@ Line 332: / Line 309: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F24W</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Phenylalanine to Tryptophan. Foldit-created linker,
@@ Line 343: / Line 317: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>F24Y</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Phenylalanine to Tyrosine. Foldit-created linker, Circular
@@ Line 355: / Line 326: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F24Y,
    L40R</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 40 on CapDCP from Phenylalanine to Tyrosine and Leucine to Arginine,
@@ Line 368: / Line 336: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F24Y,
    L40R, T59N</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, 59 on CapDCP from Phenylalanine to Tyrosine, Leucine to
@@ Line 381: / Line 346: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>F24Y,R305K</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 305 on CapDCP from Phenylalanine to Tyrosine and Arginine to Lysine,
@@ Line 393: / Line 355: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>F24Y,T59N</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 59 on CapDCP from Phenylalanine to Tyrosine and Threonine to
@@ Line 405: / Line 364: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>F24Y,T59N,R305K</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 59, and 356 on CapDCP from Phenylalanine to Tyrosine, Threonine to
@@ Line 417: / Line 373: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>F60W</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Phenylalanine to Tryptophan. Foldit-created linker,
@@ Line 428: / Line 381: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>G79A</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Glycine to Alanine. Foldit-created linker, Circular
@@ Line 439: / Line 389: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>I83T</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Isoleucine to Threonine. Foldit-created linker, Circular
@@ Line 450: / Line 397: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>I83V</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Isoleucine to Valine. Foldit-created linker, Circular
@@ Line 461: / Line 405: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>L40A</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Leucine to Alanine. Foldit-created linker, Circular
@@ Line 472: / Line 413: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>L40R</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Leucine to Arginine. Foldit-created linker, Circular
@@ Line 483: / Line 421: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>L40S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Leucine to Serine. Foldit-created linker, Circular
@@ Line 494: / Line 429: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>L40W</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Leucine to Tryptophan. Foldit-created linker, Circular
@@ Line 505: / Line 437: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>M61H</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Methionine to Histidine. Foldit-created linker, Circular
@@ Line 516: / Line 445: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>M61N</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Methionine to Asparagine. Foldit-created linker, Circular
@@ Line 527: / Line 453: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>M61S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Methionine to Serine. Foldit-created linker, Circular
@@ Line 538: / Line 461: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>N23K</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Asparagine to Lysine. Foldit-created linker, Circular
@@ Line 549: / Line 469: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>N23Q</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Asparagine to Glutamine. Foldit-created linker, Circular
@@ Line 560: / Line 477: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>S143K</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Serine to Lysine. Foldit-created linker, Circular
@@ Line 572: / Line 486: @@
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>S22I,
    T59A</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 59 on CapDCP from Serine to Isoleucine and Threonine to Alanine,
@@ Line 585: / Line 496: @@
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>S22Q,
    T59Q</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 59 on CapDCP from Serine to Glutamine and Threonine to Glutamine,
@@ Line 598: / Line 506: @@
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>S57H,
    M61H</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Serine to Histidine and Methionine to Histidine,
@@ Line 611: / Line 516: @@
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T18L,
    T59Q, M61N, F452W</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 59, 61, and 452 on CapDCP from Threonine to Leucine, Threonine to
@@ Line 624: / Line 526: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T18S_T20S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 20 on CapDCP from Threonine to Serine and Threonine to Serine,<span
@@ Line 636: / Line 535: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20A</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Threonine to Alanine. Foldit-created linker, Circular
@@ Line 647: / Line 543: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20C</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Threonine to Cystine. Foldit-created linker, Circular
@@ Line 658: / Line 551: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Threonine to Serine. Foldit-created linker, Circular
@@ Line 670: / Line 560: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40D</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 40 on CapDCP from Threonine to Serine and Leucine to Asparagine,
@@ Line 683: / Line 570: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40E</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 40 on CapDCP from Threonine to Serine and Leucine to Glutamic Acid,
@@ Line 696: / Line 580: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40F</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 40 on CapDCP from Threonine to Serine and Leucine to Phenylalanine,
@@ Line 709: / Line 590: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40H</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 40 on CapDCP from Threonine to Serine and Leucine to Histidine,
@@ Line 722: / Line 600: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40K</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 40 on CapDCP from Threonine to Serine and Leucine to Lysine,
@@ Line 735: / Line 610: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40Q</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 40 on CapDCP from Threonine to Serine and Leucine to Glutamine,
@@ Line 748: / Line 620: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40R</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 40 on CapDCP from Threonine to Serine and Leucine to Arginine,
@@ Line 761: / Line 630: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40R, F60E</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and
@@ Line 774: / Line 640: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40R, F60Q</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and
@@ Line 787: / Line 650: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40R, N81E</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, and 60 on CapDCP from Threonine to Serine, Leucine to Arginine, and
@@ Line 800: / Line 660: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40R, N81Q</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, and 81 on CapDCP from Threonine to Serine, Leucine to Arginine, and
@@ Line 813: / Line 670: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40R, T59K</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, and 59 on CapDCP from Threonine to Serine, Leucine to Arginine, and
@@ Line 826: / Line 680: @@
    <td height=93 class=xl6713667 width=172 style='height:69.95pt;width:129pt'>T20S,
    L40R, T59K_M61S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 40, 59, and 61 on CapDCP from Threonine to Serine, Leucine to Arginine,
@@ Line 840: / Line 691: @@
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,
    T59Q, M61T</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 59, and 61 on CapDCP from Threonine to Serine, Threonine to Glutamine,
@@ Line 852: / Line 700: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61A</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Alanine,
@@ Line 864: / Line 709: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61C</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Cystine,
@@ Line 876: / Line 718: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61D</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Aspartic Acid,
@@ Line 888: / Line 727: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61G</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Glycine,
@@ Line 900: / Line 736: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61L</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Leucine,
@@ Line 912: / Line 745: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61N</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Asparagine,
@@ Line 924: / Line 754: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Serine,
@@ Line 936: / Line 763: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61T</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Threonine,
@@ Line 948: / Line 772: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,M61V</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Valine,
@@ Line 960: / Line 781: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,T59N</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 59 on CapDCP from Threonine to Serine and Threonine to Asparagine,
@@ Line 972: / Line 790: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S,T59S_M61S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 59, and 61 on CapDCP from Threonine to Serine, Threonine to Serine, and
@@ Line 984: / Line 799: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S_F24H</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 24 on CapDCP from Threonine to Serine and Phenylalanine to Histidine,
@@ Line 996: / Line 808: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S_F24Y</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 24 on CapDCP from Threonine to Serine and Phenylalanine to Tyrosine,
@@ Line 1,008: / Line 817: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T20S_F24Y,T59N</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 24, and 59 on CapDCP from Threonine to Serine, Phenylalanine to Tyrosine,
@@ Line 1,020: / Line 826: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T2A</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue 2
    on CapDCP from Threonine to Alanine. Foldit-created linker, Circular
@@ Line 1,031: / Line 834: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T2C</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at destroying all activity with poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue 2
    on CapDCP from Threonine to Cystine. Foldit-created linker, Circular
@@ Line 1,041: / Line 842: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T2S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue 2
    on CapDCP from Threonine to Serine. Foldit-created linker, Circular
@@ Line 1,052: / Line 850: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T2S,T18S_T20S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 18, and 20 on CapDCP from Threonine to Serine, Threonine to Serine, and
@@ Line 1,064: / Line 859: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T2S,T18S_T20S,T59S_M61S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 18, 20, 59, and 61 on CapDCP from Threonine to Serine, Threonine to
@@ Line 1,077: / Line 869: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T2S,T20S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 20 on CapDCP from Threonine to Serine and Threonine to Serine,
@@ Line 1,089: / Line 878: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T2V</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at destroying all activity with poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue 2
    on CapDCP from Threonine to Valine. Foldit-created linker, Circular
@@ Line 1,099: / Line 886: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T59H_M61A</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Histidine and Methionine to Alanine,
@@ Line 1,111: / Line 895: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T59H_M61T</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Histidine and Methionine to Threonine,
@@ Line 1,123: / Line 904: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T59M</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Threonine to Methionine. Foldit-created linker, Circular
@@ Line 1,134: / Line 912: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T59N</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Threonine to Asparagine. Foldit-created linker, Circular
@@ Line 1,145: / Line 920: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T59Q</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Threonine to Glutamine. Foldit-created linker, Circular
@@ Line 1,157: / Line 929: @@
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T59Q,
    M61Q, F452W</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 , 61, and 452 on CapDCP from Threonine to Glutamine, Threonine to
@@ Line 1,170: / Line 939: @@
   <tr height=93 style='mso-height-source:userset;height:69.95pt'>
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T59S</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residue
 on CapDCP from Threonine to Serine. Foldit-created linker, Circular
@@ Line 1,182: / Line 948: @@
    <td height=93 class=xl6613667 width=172 style='height:69.95pt;width:129pt'>T59S,
    M61H</td>
-  <td class=xl6513667 width=216 style='width:162pt'>A mutated CapDCP protein
-  aimed at increasing hydrolysis and decreasing transpeptidation of
-  poly-D-gamma-glutamate.</td>
    <td class=xl6513667 width=297 style='width:223pt'>Point mutation at residues
 and 61 on CapDCP from Threonine to Serine and Methionine to Histidine,
@@ Line 1,195: / Line 958: @@
   <tr height=0 style='display:none'>
    <td width=172 style='width:129pt'></td>
-  <td width=216 style='width:162pt'></td>
    <td width=297 style='width:223pt'></td>
    <td width=168 style='width:126pt'></td>
@@ Line 1,212: / Line 974: @@
 </html>
+<!---------------------------------------PAGE CONTENT GOES ABOVE THIS---------------------------------------->
+<div style="text-align:center">
+'''&larr; [[Team:Washington/Gram_Positive/Test|Back to Testing the Gram(+) Therapeutic]]'''
+&nbsp; &nbsp; &nbsp;
+</div>

Team:Washington/DataTable

From 2010.igem.org

Latest revision as of 20:37, 25 October 2010

Mutant Data Table