Team:TU Munich/Templates/Beginn1Home

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<a href="https://2010.igem.org/Team:TU_Munich" style="position: fixed; top: 19px; z-index: 10;"><img src="https://static.igem.org/mediawiki/2010/c/c6/Team_TU_Munich2010_Images_Banner.jpg" width="975" height="200" border="0" /></a>
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<td align=center valign=middle><img src="https://static.igem.org/mediawiki/2010/5/57/Team_TU_Munich2010_Images_tumigem_logo_white.jpg" border=0 width=189 height=138/></td>
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<td><p align="justified" style="line-height:1.2em; margin-right:50px; margin-left: 22px; margin-top: 15px;"><span style="font-weight: bold;">Abstract&nbsp;&nbsp;&nbsp;&nbsp;</span>Among the goals of iGEM is the creation of synthetic biological parts and their utilization to achieve novel features and behavior in biological systems. The emphasis of our project is put on this latter, "systems" aspect of iGEM. More precisely, we aim at the development and experimental demonstration of a scalable approach for the realization of logical functions in vivo.<br>By developing a computational biological network based on RNA logical devices we will offer everyone the opportunity to 'program' their own cells with individual AND/OR/NOT connections between BioBricks of their choice. Thereby, BioBricks can finally fulfill their original assignment as biological parts that can be connected in many different ways. We will achieve this by engineering simple and easy-to-handle switches based on predictable RNA/RNA-interactions regulating transcriptional termination. These switches represent a complete set of logical functions and are capable of forming arbitrarily complex networks.</p></td>
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<a class="abstract_by" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/9/90/Team_TU_Munich2010_Images_flag_by.jpg" title="Bavarian" border=0 /></a>
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<a class="abstract_dm" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/8/85/Team_TU_Munich2010_Images_flag_dm.jpg" title="Danish" border=0 /></a>
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<a class="abstract_po" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/e/ea/Team_TU_Munich2010_Images_flag_po.jpg" title="Portuguese" border=0 /></a>
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<a class="abstract_ro" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/d/dc/Team_TU_Munich2010_Images_flag_ro.jpg" title="Romania" border=0 /></a>
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<a class="abstract_it" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/0/08/Team_TU_Munich2010_Images_flag_it.jpg" title="Italian" border=0 /></a>
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<a class="abstract_fr" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/9/97/Team_TU_Munich2010_Images_flag_fr.jpg" title="French" border=0 /></a>
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<a class="abstract_de" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/e/ea/Team_TU_Munich2010_Images_flag_de.jpg" title="German" border=0 /></a>
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<a class="abstract_sp" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/a/ab/Team_TU_Munich2010_Images_flag_sp.jpg" title="Spanish" border=0 /></a>
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<a class="abstract_ru" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/f/f6/Team_TU_Munich2010_Images_flag_ru.jpg" title="Russian" border=0 /></a>
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<a class="abstract_ch" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/4/4e/Team_TU_Munich2010_Images_flag_ch.jpg" title="Chinese" border=0 /></a>
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<a class="abstract_en" href="#" style="float: right; border: 1px solid black; margin: 1px;"><img src="https://static.igem.org/mediawiki/2010/6/6b/Team_TU_Munich2010_Images_flag_en.jpg" title="English" border=0 /></a>
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<p class="abstract_de" style="display: none; clear: right;">Das Entwickeln neuer Bausteine für die synthetische Biologie und der Gewinn neuer Eigenschaften und Funktionen biologischer Systeme durch die Kombination selbiger ist eines der Hauptziele des iGEM-Wettbewerbes. In unserem Projekt legen wir den Fokus vor allem auf letzteres, mit dem Ziel, eine systemische Anwendung von iGEM-Bausteinen zu etablieren. Wir wollen ein beliebig erweiterbares System entwerfen, das biologische Teile in vivo zu einem Netzwerk zusammenfügt und somit eine logische Informationsverarbeitung erlaubt.<br>
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Durch die Entwicklung eines biologischen Netzwerkes, das analog zu einem Computer aufgebaut ist, bieten wir allen Wissenschaftlern die Möglichkeit, Zellen zu programmieren und logische Netzwerke basierend auf AND/OR/NOT-Verbindungen zwischen Biobrick-Parts zu entwickeln. Dadurch können Biobricks funktionell miteinander verknüpft werden und endlich auch ihre Funktion als biologische Bausteine erfüllen. Um dies zu erreichen, haben wir einfache und benutzerfreundliche Schalter basierend auf modellierbaren RNA-RNA-Interaktionen konstruiert, die durch Antitermination schalten können. Mit Hilfe dieser Schalter kann man logische Gates aufbauen und beliebig komplexe Netzwerke entwerfen.</p>
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<p class="abstract_en" style="display: none; clear: right;">Among the goals of iGEM is the creation of synthetic biological parts and their utilization to achieve novel features and behavior in biological systems. The emphasis of our project is put on this latter, "systems" aspect of iGEM. More precisely, we aim at the development and experimental demonstration of a scalable approach for the realization of logical functions in vivo.<br>By developing a computational biological network based on RNA logical devices we will offer everyone the opportunity to 'program' their own cells with individual AND/OR/NOT connections between BioBricks of their choice. Thereby, BioBricks can finally fulfill their original assignment as biological parts that can be connected in many different ways. We will achieve this by engineering simple and easy-to-handle switches based on predictable RNA/RNA-interactions regulating transcriptional termination. These switches represent a complete set of logical functions and are capable of forming arbitrarily complex networks.</p>
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<p class="abstract_ch" style="display: none; clear: right;">
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iGEM(国际遗传工程机器设计竞赛)的主要目的是,通过创造新的合成生物学部件极其有机组合,来实现生物系统新的特性与机能。我们的项目着重于 后者—系统的设计。具体地说,我们的目的是开发并通过实验来展示一个可量化的系统结构,来实现在生物活体内进行逻辑信息处理过程。
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通过开发基于RNA逻辑部件的计算生物学网络,我们能提供每个人一个机会,自由选择与/或/非门来连接各种BioBrick(标准化生物学部件),为细胞” 编程”。这样,各个BioBrick既可以完成原本的生物机能,又可以以各种不同的形式相互连接。为此,我们将设计简单并且易操作的开关实现此目的,而这些开关是通过可计算的RNA/RNA相互作用调控转录终止实现的。这些开关能够实现全部的基本逻辑运算功能,从而可用其来设计并组建复杂的网络。</p>
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<p class="abstract_by" style="display: none; clear: right;">As Entwickeln von neie Baustoana fia de synthetische Biologie und da Gwinn neia Eigenschoftn und Funktiona biologischa Systeme durch de Kombination selbiga is oans da Hauptziele des iGEM-Wettbewerbs. In unsam Projekt legn mia den Fokus voa oiem auf letzters mit dem Ziel, a systemische Owendung von iGEM-Baustoana zua etobliarn. Mia woin a beliabig erweiderbars System buidn, wos biologische Teile in vivo zua am Netzwerk vabindt und somit a logische Infoamadionsveroabadung erlaubt.<br>
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Durch de Entwicklung vo am biologischn Netzwerk, des grod aso wia a Computa aufbaut is, bietn mia olle Wissenschoftler de Möglichkeit, Zelln zua programmiern und logische Netzwerke basierend auf AND/OR/NOT-Verbindunga zwischn Biobrick-Stückln zua entwickln. Dadurch kenna Biobricks funktionell mitananda vaknüpft werdn und endli aa ihre Funktion ois biologische Baustoana dafülln. Um des zua erreichn, hobn mia oafache und benutzerfreindliche Schoita basierend auf modelliarbarn RNA-RNA-Interaktiona konschtruiert, de durch Antitermination schoitn kenna. Mittels dera Schoita kost jetzta komplette logische Schoita aufbaun und beliabig komplexe Netzwerke entwerffa.</p>
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<p class="abstract_sp" style="display: none; clear: right;">Entre los objetivos de iGEM se encuentra la creación sintética de partes biológicas y su utilización para lograr nuevas conductas y características en los sistemas biológicos. El énfasis de nuestro proyecto se centra en esto último, en los sistemas como característica principal de iGEM. Concretamente, nuestro objetivo es el desarrollo y la demostración experimental de un enfoque escalable para la realización de funciones lógicas en seres vivos. Mediante el desarrollo de una red computacional biológica basada en dispositivos lógicos ARN, vamos a ofrecer a todo el mundo la oportunidad de "programar" con sus propias células mediante conexiones individuales AND/OR/NOT entre BioBricks de su propia elección. De tal modo, los BioBricks pueden llevar a cabo su tarea principal como partes biológicas que se pueden conectar de muchas maneras diferentes. Esto se logrará mediante sencilla ingeniería e interruptores fáciles de manejar basados en interacciones ARN-ARN sencillas de predecir, regulando las interacciones de terminación de la transcripción. Estos conmutadores representan un conjunto completo de funciones lógicas y son capaces de formar cualquier red compleja.</p>
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<p class="abstract_po" style="display: none; clear: right;">Entre os objectivos de iGEM está a criação de peças biológicas sinteticamente concebidas e a sua utilização de modo a alcançar propriedades e comportamentos inovadores em sistemas biológicos. Neste projecto, ênfase é colocado neste último aspecto de iGEM denominado “sistemas”. Mais precisamente, nós temos a intenção do desenvolvimento e da demonstração experimental de uma aproximação escalável para a realização de funções lógicas em vivo.<br>Ao desenvolver uma rede computacional biológica baseada em aparelhos lógicos de RNA, nós vamos oferecer a todos a oportunidade de “programar” as suas próprias células com conexões individuais de e/ ou/ sem entre BioBricks de sua escolha. Desta forma as BioBricks podem finalmente cumprir a sua tarefa original, como peças biológicas que podem ser conectadas de várias maneiras diferentes. Nós vamos alcançar isto através da construção de interruptores simples de uso fácil baseados em previsíveis interacções entre RNAs, que regulam a terminação da transcrição. Estes interruptores representam um completo aparelho de funções lógicas que são capazes de arbitrariamente formar redes complexas.</p>
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<p class="abstract_dm" style="display: none; clear: right;">Blandt målene for iGEM er skabelsen af syntetiske biologiske dele og deres anvendelse i opnåelsen af nye egenskaber i biologiske systemer. Vores fokus er på den sidste del af disse to formål, nemlig system aspektet af iGEM. Specifikt stræber vi mod udvikling og demonstration af eksperimentel anvendelse af en skalerbar tilgang for realisering af logiske funktioner in vivo.
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Gennem udvikling af et biologisk beregningsnetværk baseret på RNA-logiske-enheder vil vi tilbyde muligheden for programmering af egne celler ved hjælp af individuelle AND/OR/NOT forbindelser mellem valgfrie BioBricks. Herved kan BioBricks endelig opfylde deres oprindelige formål som biologiske dele, der kan forbindes på mange forskellige måder. Dette vil vi opnå ved at designe enkle og nemt håndterbare kontakter baseret på forudsigelige RNA/RNA-vekselvirkninger, der regulerer transkriptionel afslutning. Disse kontakter repræsenterer et komplet sæt af logiske funktioner og er i stand til at danne et netværk af arbitrær kompleksitet. </p>
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<p class="abstract_fr" style="display: none; clear: right;">L'un des plusieurs buts d'iGEM est la création des parties biologiques synthétiques qui peuvent être utiliser pour découvrir des nouvelles caractéristiques et comportements des systèmes biologiques. L'accent de notre projet est mis sur ce dernier aspect de "systèmes".
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Plus précis, notre objectif et de réaliser des fonctions logiques in vivo sur la base d'une approche expérimentale.
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En développant un réseau biologique et quantificatif à l'aide des structures logiques de l'ARN, nous offrirons à chacun la possibilité de programmer ses propres cellules avec les connexions AND/OR/NOT individuelles entre les biobriques de son choix.<br>Ainsi, les biobriques peuvent finalement réaliser leur fonction initiale: alors comme parties biologiques qui peuvent être connecter de plusieurs façons différentes. Nous atteignons cela avec des interrupteurs facile à commander. Ils sont installés d'après le modèle des interactions ARN/ARN et régulent aussi l'achèvement transcriptional. Ces interrupteurs représentent un ensemble complet des fonctions logiques et ils sont arbitrairement capables de former des réseaux complexes.</p>
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<p class="abstract_it" style="display: none; clear: right;">La creazione di nuovi elementi per la biologia sintetica e la loro coordinazione, al fine di creare nuove funzioni e caratteristiche biologiche, sono il fine principe del concorso iGEM.
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Vogliamo concentrarci particolarmente alle applicazioni sistemiche degli elementi iGEM. Piu precisamente stiamo cercando di sviluppare e di dimostrare l'avvicinamento a la realizzazione modulare di funzioni logiche “in-vivo”.
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Attraverso il sviluppo di una rete biologica offriamo a tutti la possibilità di una programmazione cellulare e di sviluppare logiche reti basate sulla combinazione di BioBrick-elementi lavoranti secondo i legami AND/OR/NOT.
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In questo modo i BioBrick possono finalmente espletare le loro funzioni come elementi biologici che possono essere connessi in qualsiasi modo. Per raggiungere questo, abbiamo costruito interruttori facili da usare, basati sulla calcolabile interazione dei gruppi genomici RNA-RNA.
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Col aiuto di questi interruttori si possono costruire completi funzioni logici e qualsiasi reti complessi
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<p class="abstract_ru" style="display: none; clear: right;">Среди целей ИГЕМ (iGEM)является создание синтетических биологических частей и их использование для достижения новых особенностей и поведения в биологических системах. Основное внимание в рамках нашего проекта ИГЕМ(iGEM) ставится на такие  "системы ". Более точно, мы нацелены на развитие и экспериментальную демонстрацию масштабируемого подхода для реализацию логических функций в естественных условиях.
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К разработке вычислительных биологических сетий на основе РНК-логических устройств мы предлогаем каждому возможность "программировать" свой  собственные клетки с индивидуальной И / ИЛИ / НЕ связей между BioBricks по своему выбору. Таким образом, BioBricks может, наконец, выполнить свои первонача́льный  назначение в качестве биологических частей, которые могут быть соединёны различным способам. Мы достигнем это, через простую и лёгкую обращения переключателей на основе предсказуемых РНК и РНК-взаимодействия регулирующих транскрипционных прекращения. Эти выключатели представляют полный набор логических функций которие способны образовывать любой  сложный сеть.</p>
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<p class="abstract_ro" style="display: none; clear: right;">Unul dintre scopuri dela iGEM este a crea părţi artificiale bioligice care se pot utiliza pentru descoperirea unor caracteristici noi într-un sistem biologic. Accentul proiectului nostru este pus pe punctul de "sistem" al-ui iGEM. Mai exact, scopul nostru este să demonstrâm funcţi logice "in vivo" prin ataşare şi dezvoltare continuă.<br>Proiectul iGem dezvolta prin calcul o reţea biologica, cu componente basate pe logica acidului ribonucleic. Aşa oferim tuturor posibilitatea să controleze celulele lor cu o legatură (AND/OR/NOT) între BioBricks care sunt alese individual. Ca părţi biologice care pot fi conectate în mai multe moduri diferite, BioBricks poate îndeplini sarcina iniţială. Vom realiza acest lucru prin întrerupătoare simple şi uşoare de manevrat care sunt bazate pe interacţiuni ARN/ARN  previsibile şi care controlează încetarea transcripţională. Aceste întrerupătoare reprezintă un set complet de funcţii logice şi sunt capabile să formeze arbitrar reţele complexe</p>
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Latest revision as of 23:08, 27 October 2010