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From 2010.igem.org

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Revision as of 19:28, 22 October 2010

Among the goals of iGEM is the creation of synthetic biological parts and their utilization to achieve novel features and behavior in biological systems. The emphasis of our project is put on this latter, "systems" aspect of iGEM. More precisely, we aim at the development and experimental demonstration of a scalable approach for the realization of logical functions in vivo.
By developing a computational biological network based on RNA logical devices we will offer everyone the opportunity to 'program' their own cells with individual AND/OR/NOT connections between BioBricks of their choice. Thereby, BioBricks can finally fulfill their original assignment as biological parts that can be connected in many different ways. We will achieve this by engineering simple and easy-to-handle switches based on predictable RNA/RNA-interactions regulating transcriptional termination. These switches represent a complete set of logical functions and are capable of forming arbitrarily complex networks.

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 Durch die Entwicklung eines biologischen Netzwerkes, das analog zu einem Computer aufgebaut ist, bieten wir allen die Mögichkeit, Zellen zu programmieren und logische Netzwerke basierend auf AND/OR/NOT-Verbindungen zwischen Biobrick-Parts zu entwickeln. Dadurch können Biobricks auch endlich ihre Funktion als biologische Bausteine, die beliebig miteinander verknüpft werden können, erfüllen. Um das zu erreichen, haben wir einfache und benutzerfreundliche Schalter basierend auf berechenbaren RNA-RNA-Interaktion konstruiert, die durch Antitermination schalten können. Mit Hilfe dieser Schalter kann man komplette logische Funktionen aufbauen und beliebig komplexe Netzwerke entwerfen.</p>
 <p class="abstract_en" style="clear: right;">Among the goals of iGEM is the creation of synthetic biological parts and their utilization to achieve novel features and behavior in biological systems. The emphasis of our project is put on this latter, "systems" aspect of iGEM. More precisely, we aim at the development and experimental demonstration of a scalable approach for the realization of logical functions in vivo.<br>By developing a computational biological network based on RNA logical devices we will offer everyone the opportunity to 'program' their own cells with individual AND/OR/NOT connections between BioBricks of their choice. Thereby, BioBricks can finally fulfill their original assignment as biological parts that can be connected in many different ways. We will achieve this by engineering simple and easy-to-handle switches based on predictable RNA/RNA-interactions regulating transcriptional termination. These switches represent a complete set of logical functions and are capable of forming arbitrarily complex networks.</p>
-<p class="abstract_ch" style="display: none; clear: right;">概述
+<p class="abstract_ch" style="display: none; clear: right;">
-IGEM（国际遗传工程机器设计竞赛）的主要目的是，通过创造新的合成生物学部件极其有机组合，来实现生物系统新的特性与机能。我们的项目着重于 后者—系统的设计。具体地说，我们的目的是开发并通过实验来展示一个可量化的系统结构，来实现在生物活体内进行逻辑信息处理过程。
+iGEM（国际遗传工程机器设计竞赛）的主要目的是，通过创造新的合成生物学部件极其有机组合，来实现生物系统新的特性与机能。我们的项目着重于 后者—系统的设计。具体地说，我们的目的是开发并通过实验来展示一个可量化的系统结构，来实现在生物活体内进行逻辑信息处理过程。
 通过开发基于RNA逻辑部件的计算生物学网络，我们能提供每个人一个机会，自由选择与/或/非门来连接各种BioBrick（标准化生物学部件），为细胞” 编程”。这样，各个BioBrick既可以完成原本的生物机能，又可以以各种不同的形式相互连接。为此，我们将设计简单并且易操作的开关实现此目的，而这些开关是通过可计算的RNA/RNA相互作用调控转录终止实现的。这些开关能够实现全部的基本逻辑运算功能，从而可用其来设计并组建复杂的网络。</p>
 <p class="abstract_by" style="display: none; clear: right;">bavarian</p>