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From 2010.igem.org

Contents 1 Hassan

Hassan

• Databases we should choose better not to be predicted databases, such as String, or we can use these type of databases with more care, on the other hand databases which include experimentally proven PPI from small scale or large scale studies seem to be more useful for now. There is also another type of databases that are of interest, are Meta-databases, these are as joint point for different primary databases and integrating them. [1]

• A first obstacle to evaluate the reliability of PPIs is the low coverage of the databases for each specific interactome. One way to increase coverage is to integrate data reported by different primary databases.....Once the coverage is the best possible for a given interactome, strategies for selecting reliable PPIs are needed.[2]