Team:Stanford

From 2010.igem.org

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[[Image:ShinyLogo.png|right|200px|Our Team Logo]]
[[Image:ShinyLogo.png|right|200px|Our Team Logo]]
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==Our Project: EscheRatio Coli!==
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==Our Project: EscheRatio Coli==
This year our team created a new tool for the synthetic biologist's toolkit: a system to allow E. coli to sense the ratio of two different chemicals in its environment and produce a protein output based on that ratio. <br/>
This year our team created a new tool for the synthetic biologist's toolkit: a system to allow E. coli to sense the ratio of two different chemicals in its environment and produce a protein output based on that ratio. <br/>
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==Acknowledgements==
==Acknowledgements==
The following individuals have played an instrumental role in the success of our iGEM team.  We would like to extend our heartfelt appreciation to the following faculty, postdocs and graduate students:  
The following individuals have played an instrumental role in the success of our iGEM team.  We would like to extend our heartfelt appreciation to the following faculty, postdocs and graduate students:  
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[[Image:BioXLogo.jpg|right|Stanford BioX]]
 
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[[Image:StanfordVPUE.png|right|180px|Stanford Vice Provost of Undergraduate Education]]
 
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[[Image:StanfordBioEng.png|right|180px|Stanford Department of Bioengineering]]
 
'''Faculty Sponsors'''
'''Faculty Sponsors'''
*Drew Endy
*Drew Endy
*Christina Smolke
*Christina Smolke
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[[Image:BioXLogo.jpg|right|Stanford BioX]]
'''Post Graduate/Graduate Student Mentors'''
'''Post Graduate/Graduate Student Mentors'''
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*Annie Hazlehurst
*Annie Hazlehurst
*Ying Lei
*Ying Lei
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[[Image:StanfordVPUE.png|right|180px|Stanford Vice Provost of Undergraduate Education]]
*Francois St. Pierre
*Francois St. Pierre
*Ariane Tom
*Ariane Tom
*Isis Trenchard
*Isis Trenchard
*Christopher VanLang
*Christopher VanLang
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[[Image:StanfordBioEng.png|right|180px|Stanford Department of Bioengineering]]
*Rayka Yokoo
*Rayka Yokoo
*Bo Zhou
*Bo Zhou
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'''Our Executive Director'''
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'''Executive Director'''
*Anusuya Ramasubramanian
*Anusuya Ramasubramanian
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[[Image:Dfj.jpg|150px|right]]
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'''Sponsors'''
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*[http://bioengineering.stanford.edu/ Stanford University Department of Bioengineering]
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*[http://biox.stanford.edu/ Stanford BioX Initiative]
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*[http://www.stanford.edu/dept/undergrad/cgi-bin/drupal/ Stanford University Vice Provost for Undergraduate Education]
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*[http://www.dfj.com/ Draper Fisher Jurvetson Venture Group]
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'''Our Sponsors'''
 
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*Stanford University Department of Bioengineering
 
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*Bio-X 
 
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*Stanford University Vice Provost for Undergraduate Education
 
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Ratios of growth factor to receptors can indicate the malignancy of tumors and predict when they are likely to metastasize. Our sensor could be used as either a research tool to discover more important ratios or as a method of targeting in-vivo drug delivery to those cells with tumor-like expression patterns.
 
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Bacterial manufacturing has huge economic potential, but is often limited by the efficiency of biological pathways. Our sensor could be used to regulate enzyme production, inhibiting enzyme output in the absence of substrate and increasing output once substrate becomes abundant.
 
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Preterm labor is a leading cause of infant mortality, even in the US. Our sensor could detect hormone or bacterial imbalance and alert the expectant mother or her doctor that she is likely to enter preterm labor, allowing a pre-emptive response that could save her child's life.
 
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Revision as of 05:04, 27 October 2010

Home Project Applications Modeling Parts Team Notebook Twitter

Contents

Welcome to the Stanford team Wiki for iGEM 2010

Stanford iGEM is a student-run, faculty-directed research group at Stanford University. The objective of our interdisciplinary group is to design and build novel engineered biological systems using standardized DNA-based parts to submit to the iGEM (International Genetically Engineered Machines) competition, held annually at MIT. Our research draws from the principles of synthetic biology, an emerging interdisciplinary and multidisciplinary area that involves the design and construction of biological systems. Here is our team for the 2010 competition.

If you are looking for our winning 2009 project, check out our old site.

Our Team Logo

Our Project: EscheRatio Coli

This year our team created a new tool for the synthetic biologist's toolkit: a system to allow E. coli to sense the ratio of two different chemicals in its environment and produce a protein output based on that ratio.

We've implemented two different ratio sensor designs:

  • an sRNA-based sensor that reports the relationship between the present ratio of the chemicals and a single desired ratio via the presence or absence of signal
  • a kinase-phosphatase sensor that reports the exact ratio via the intensity of the signal

Why Ratios?

Ratios run the biological world, from the complex functions of the Circadian cycle to minute stoichiometric interactions. And yet synthetic biologists have so far had no way of utilizing chemical ratios as means of controlling cell behavior. Until now.

With the Stanford 2010 team's ratio sensors, synthetic biologists will be able to create more responsive genetic machinery capable of solving all sorts of problems. Why not take a look at a few examples on our Applications page?

Twitter Project

Our team also created an iGEM 2010 list on Twitter to allow teams to help each other solve lab problems and share ideas. Check out our story here.

Acknowledgements

The following individuals have played an instrumental role in the success of our iGEM team. We would like to extend our heartfelt appreciation to the following faculty, postdocs and graduate students:

Faculty Sponsors

  • Drew Endy
  • Christina Smolke
Stanford BioX

Post Graduate/Graduate Student Mentors

  • Graham Anderson
  • Ryan Bloom
  • Jerome Bonnet
  • Andy Chang
  • Annie Hazlehurst
  • Ying Lei
Stanford Vice Provost of Undergraduate Education
  • Francois St. Pierre
  • Ariane Tom
  • Isis Trenchard
  • Christopher VanLang
Stanford Department of Bioengineering
  • Rayka Yokoo
  • Bo Zhou

Executive Director

  • Anusuya Ramasubramanian
Dfj.jpg

Sponsors


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