Team:SDU-Denmark/safety-b

From 2010.igem.org

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<nowiki>A. characteristics of the host and donor organisms
<nowiki>A. characteristics of the host and donor organisms
1. Name(s) of the organism(s) in question
1. Name(s) of the organism(s) in question
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2. Origin of organism(s) in question
2. Origin of organism(s) in question
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3. Information on the reproductive cyclus of the parental organisms as well as the host
3. Information on the reproductive cyclus of the parental organisms as well as the host
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4. Description of any previous genetic modification
4. Description of any previous genetic modification
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5. Stability
5. Stability
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6. Details concerning pathogenesis, virulence, infectivity or toxicity
6. Details concerning pathogenesis, virulence, infectivity or toxicity
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7. characteristics of endogene vectors:
7. characteristics of endogene vectors:
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-sequence
-sequence
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-mobilisation
-mobilisation
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-specificity
-specificity
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-the presence of resistance-genes
-the presence of resistance-genes
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8. host spectrum,
8. host spectrum,
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9. potentially significant physiological traits and the stability of these traits
9. potentially significant physiological traits and the stability of these traits
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10. natural habitat
10. natural habitat
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11. significant role in environmental processes   
11. significant role in environmental processes   
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12. Competition or symbiosis with other naturally occurring organisms
12. Competition or symbiosis with other naturally occurring organisms
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13. Ability to create survival structures (i.e. the ability to create spores)
13. Ability to create survival structures (i.e. the ability to create spores)
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B. characteristics of the genetically modified organism
B. characteristics of the genetically modified organism
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1. origin of the genetic material used to modify the organism, as well as the intended functions of this material
1. origin of the genetic material used to modify the organism, as well as the intended functions of this material
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2. Description of the modification, including the method of vector insertion in the host organism, as well as the method used to create the genetically modified production-organism
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2. Description of the modification, including the method of vector insertion in the host organism, as well as the  
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method used to create the genetically modified production-organism
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3. the function of the genetic modification
3. the function of the genetic modification
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4. origin and characteristics of the vector
4. origin and characteristics of the vector
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5. structure and size of vector in the genetically modified production-organism
5. structure and size of vector in the genetically modified production-organism
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6. stability of the organism with respect to genetic traits
6. stability of the organism with respect to genetic traits
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7. mobiliseringshyppigheden of the inserted vector and/or the organism’s ability to transfer genetic material
7. mobiliseringshyppigheden of the inserted vector and/or the organism’s ability to transfer genetic material
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8. activity of the expressed protein
8. activity of the expressed protein
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C. Health concerns
C. Health concerns
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1. Toxic or allergenic properties
1. Toxic or allergenic properties
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2. Product risks
2. Product risks
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3. The genetic modified organism’s pathogenic properties compared with the donor – or the host organisms or possibly the donor organism
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3. The genetic modified organism’s pathogenic properties compared with the donor – or the host organisms or possibly  
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the donor organism
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4. Colonization ability
4. Colonization ability
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5. If the organism is pathogenic to humans, who are immune competent:
5. If the organism is pathogenic to humans, who are immune competent:
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a) Cause illness and the pathogenic mechanism, including invasiveness and virulence
a) Cause illness and the pathogenic mechanism, including invasiveness and virulence
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b) infectivity
b) infectivity
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c) infective dose
c) infective dose
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d) host range, possibility of change
d) host range, possibility of change
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e) possibility for survival outside the human host
e) possibility for survival outside the human host
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f) The presence of vectors or other distribution areas
f) The presence of vectors or other distribution areas
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g) Biological stability
g) Biological stability
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h) resistance patterns against antibiotics
h) resistance patterns against antibiotics
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i) allergencity
i) allergencity
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j) chance for suitable disease treatment
j) chance for suitable disease treatment
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D. Environmental concerns
D. Environmental concerns
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1. factors that might affect the organism’s ability for survival, reproduction and it’s ability to spread in the environment.
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1. factors that might affect the organism’s ability for survival, reproduction and it’s ability to spread in the  
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environment.
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2. techniques for detection, identification and surveillance of the modified organism
2. techniques for detection, identification and surveillance of the modified organism
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3. techniques for detection of transfer of genetic material to other organisms
3. techniques for detection of transfer of genetic material to other organisms
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4. known and expected habitats of the modified organism
4. known and expected habitats of the modified organism
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5. description of ecosystems into which the organism could spread in the event of an accident
5. description of ecosystems into which the organism could spread in the event of an accident
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6. expected result of interaction between the modified organism and naturally occurring bacteria that would be affected in the event of an accident
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7. known and expected effects on animals and plants, with regards to pathogenesis, virulence, infectivity, toxicity, allergenicity, colonisation
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6. expected result of interaction between the modified organism and naturally occurring bacteria that would be  
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affected in the event of an accident
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7. known and expected effects on animals and plants, with regards to pathogenesis, virulence, infectivity, toxicity,  
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allergenicity, colonisation
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8.known or expected contribution to bio-geo-chemic processes   
8.known or expected contribution to bio-geo-chemic processes   
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9. methods for decontamination of the area in the event of an accident</nowiki>
9. methods for decontamination of the area in the event of an accident</nowiki>
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The above list is from https://www.retsinformation.dk/Forms/R0710.aspx?id=12325
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[https://www.retsinformation.dk/Forms/R0710.aspx?id=12325 [3]]
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This clause is intended as security measure. Should the bacteria be released into the environment, the parts-registry site should contain information on how to neutralize the bacteria.
This clause is intended as security measure. Should the bacteria be released into the environment, the parts-registry site should contain information on how to neutralize the bacteria.
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If the bacteria has an kill-code inserted, the site should describe how to enact the self-destruct mechanism.  
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If the bacteria has an kill-code inserted, the site should describe how to enact the self-destruct mechanism.
==== kill-code ====  
==== kill-code ====  

Revision as of 16:06, 6 September 2010