Team:SDU-Denmark/safety-b

From 2010.igem.org

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(Risk-assessment for Individual Parts)
(Safety Concerns During Election of Project)
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<p style="text-align: justify;">During our closer investigations of project ideas we also considered which bacteria it was possible to use. Our focus was to try and find a project that was possible to carry out by using E. coli. The reasons here for being that (cultivated strains of) E. coli are very well adapted to the laboratory environment since they are easy to keep alive, they can be fairly easy modified and unlike some wild strains of E. coli they no longer have the ability to thrive inside the intestines. Despite of these considerations we started out working on a project we called mE.chanic (because we wanted to make bacteria do mechanical work), and the idea was to have a culture of bacteria contract and relax, thereby making a pump-like movement creating mechanical work.</p>
<p style="text-align: justify;">During our closer investigations of project ideas we also considered which bacteria it was possible to use. Our focus was to try and find a project that was possible to carry out by using E. coli. The reasons here for being that (cultivated strains of) E. coli are very well adapted to the laboratory environment since they are easy to keep alive, they can be fairly easy modified and unlike some wild strains of E. coli they no longer have the ability to thrive inside the intestines. Despite of these considerations we started out working on a project we called mE.chanic (because we wanted to make bacteria do mechanical work), and the idea was to have a culture of bacteria contract and relax, thereby making a pump-like movement creating mechanical work.</p>
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[[Image:SDU-Denmark-2010-pili.png|600px|thumb|left|Our first project idea involved pili, but we decided it was unsafe, because of it's potential pathogenicity.]]
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BILLLLLLEEEDDDDEEEE
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<p style="text-align: justify;">Now, we found out that we could use pili as some sort of ‘grappling hooks’ to make a connection between the bacteria. Pili from E.coli had been measured to have a pulling force of about 100 pN (enough to work a nano-machine), and so it seemed that we would have a good chance of making usable mechanical work if we continued this idea. We just needed to find out how to control the formation and retraction of the pili.</p>
<p style="text-align: justify;">Now, we found out that we could use pili as some sort of ‘grappling hooks’ to make a connection between the bacteria. Pili from E.coli had been measured to have a pulling force of about 100 pN (enough to work a nano-machine), and so it seemed that we would have a good chance of making usable mechanical work if we continued this idea. We just needed to find out how to control the formation and retraction of the pili.</p>

Revision as of 11:17, 26 October 2010