Team:Panama
From 2010.igem.org
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- | style="font-size: 0.4cm;">Rhamnolipids are naturally occurring glycolipids produced by the<span style="font-style: italic;"> Pseudomonas aeruginosa</span>. Rhamnolipids have many applications, because of their natural biosurfactant, emulsifying, fungicidal, antibiotic, and pharmaceutical properties. Also rhamnolipids can operate in extreme conditions such as high temperature, pH, and salinity. They have a low toxicity, and they are biodegradable compared to their synthetic chemical counterparts. Rhamnolipid is composed of rhamnose sugar molecule and b-hydroxyalkanoic acid. The rhamnosyltransferase 1 complex (RhlAB) is the key enzyme responsible for transferring the rhamnose moiety to the b-hydroxyalkanoic acid moiety to biosynthesize rhamnolipid. Since the organisms known to produce rhamnolipids are almost exclusively pathogens. For this reason, we propose the non-pathogenic nature of <span style="font-style: italic;">E. coli</span> as an attractive candidate for commercial rhamnolipid production by assembling our rhlAB gene | + | style="font-size: 0.4cm;">Rhamnolipids are naturally occurring glycolipids produced by the<span style="font-style: italic;"> Pseudomonas aeruginosa</span>. Rhamnolipids have many applications, because of their natural biosurfactant, emulsifying, fungicidal, antibiotic, and pharmaceutical properties. Also rhamnolipids can operate in extreme conditions such as high temperature, pH, and salinity. They have a low toxicity, and they are biodegradable compared to their synthetic chemical counterparts. Rhamnolipid is composed of rhamnose sugar molecule and b-hydroxyalkanoic acid. The rhamnosyltransferase 1 complex (RhlAB) is the key enzyme responsible for transferring the rhamnose moiety to the b-hydroxyalkanoic acid moiety to biosynthesize rhamnolipid. Since the organisms known to produce rhamnolipids are almost exclusively pathogens. For this reason, we propose the non-pathogenic nature of <span style="font-style: italic;">E. coli</span> as an attractive candidate for commercial rhamnolipid production by assembling our rhlAB gene into a BioBrick using synthetic biology to engineer these new rhlAB producing bacteria for human benefit.</span></span></span></span></p> |
Revision as of 00:16, 16 July 2010