Team:Northwestern
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Chitin, found in the exoskeletons of insects and crustaceans, is one of the most abudant substances in nature. Like keratin in skin, it comprises the protective outer layer of these animals. Our chitin expression platform involves generating a layer of chitin from a lawn of bacteria in response to an external molecular cue. This cue induces chitin synthesis (fast) and cell lysis (slow). This system allows for a build-up of chitin followed by cell lysis and subsequent release into the top layer of the lawn. Abrasions expose cells to the external cue for self-repair. In this way, we create a regenerative chitin biolayer with potential medical and industrial applications. | Chitin, found in the exoskeletons of insects and crustaceans, is one of the most abudant substances in nature. Like keratin in skin, it comprises the protective outer layer of these animals. Our chitin expression platform involves generating a layer of chitin from a lawn of bacteria in response to an external molecular cue. This cue induces chitin synthesis (fast) and cell lysis (slow). This system allows for a build-up of chitin followed by cell lysis and subsequent release into the top layer of the lawn. Abrasions expose cells to the external cue for self-repair. In this way, we create a regenerative chitin biolayer with potential medical and industrial applications. | ||
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Revision as of 21:54, 3 October 2010
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SCIN - Self-regenerating Chitin INduction Chitin, found in the exoskeletons of insects and crustaceans, is one of the most abudant substances in nature. Like keratin in skin, it comprises the protective outer layer of these animals. Our chitin expression platform involves generating a layer of chitin from a lawn of bacteria in response to an external molecular cue. This cue induces chitin synthesis (fast) and cell lysis (slow). This system allows for a build-up of chitin followed by cell lysis and subsequent release into the top layer of the lawn. Abrasions expose cells to the external cue for self-repair. In this way, we create a regenerative chitin biolayer with potential medical and industrial applications. |
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== Project Description: Bacterial Skin ==
Medicinal Use:
Industrial Use:
Side Project: Magnetite ProductionOur side project is to synthesize superparamagnetic magnetite nanoparticles in E Coli. Nano-manipulation of magnetite particles, which can lead to a plethora of advances, especially in research technology and biomedical technology. Understanding and utilization of magnetotaxis and/or magnetoception in bacteria. Possible production and use of ferrofluid, a paramagnetic or superparamagnetic fluid. Ability to create uniform nanoparticles will further nanotechnology. (biotech is nanotech that works) Northwestern UniversityNorthwestern University in Evanston, IL, combines innovative teaching and pioneering research in a highly collaborative environment that transcends traditional academic boundaries. Our lab facilities are located at: Technological Institute 2145 Sheridan Road, Evanston, IL 60208 Find out more about Northwestern University Find out more about McCormick School of Engineering Find out more about Weinberg College of Arts and Sciences Sponsors |