From 2010.igem.org
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Cell Line
The cell line used in this project is the human embryonic kidney cell line 293T .
Databases Search
The NCBI GEO and ArrayExpress databases were extensively searched for environmental conditions leading to apoptosis in 293T cells and genes differentially expressed under these conditions. The following data was obtained:
Environmental Condition (EV)
| #genes selectively expressed in this EV
| Reference
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Conduritol B Epoxide treatment
| 57
| [1]
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Gammaherpesvirus
| 103
| [2]
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HIV integration
| 1
| [3]
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HLTV-1 p30
| 2291
| [4]
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Hypoxia
| 2
| [5]
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RCAS-beta-cateinS37A
| 55
| [6]
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[1] Reference one Geo
[1] Reference one Geo
[1] Reference one Geo
[1] Reference one Geo
[1] Reference one Geo
[1] Reference one Geo
In order to understand gene regulation of apoptosis regulated genes we used the Transcriptional Regulatory Element Database (TRED) to extract known promoters and the STRING database for known interactions between genes and their transcription factors.
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