Team:LMU-Munich/ProSearch/Schedule
From 2010.igem.org
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! Environmental Condition (EV) | ! Environmental Condition (EV) | ||
- | ! align="center"| | + | ! align="center"|Number of genes differentially expressed |
! align="center"|Reference | ! align="center"|Reference | ||
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- | [1] | + | [1] Campeau PM, Rafei M, Boivin MN, Sun Y et al. Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome. Blood 2009 Oct 8;114(15):3181-90. [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13675 GEO Link] |
- | [ | + | [2] Gene Expression and Transcription Factor Profiling Reveal Inhibition of Transcription Factor cAMP-response Element-binding Protein by {gamma}-Herpesvirus Replication and Transcription Activator. Brown HJ, Peng L, Harada JN, Walker JR, Cole S, Lin SF, Zack JA, Chanda SK, Sun R. J Biol Chem 285(33):25139-53 [http://www.ebi.ac.uk/arrayexpress/browse.html?keywords=E-MEXP-1437&species=&array=&exptype[]=&exptype[]=&pagesize=25&sortby=releasedate&sortorder=descending&expandefo=on Array Express Link] |
- | [ | + | [3] A role for LEDGF/p75 in targeting HIV DNA integration. Angela Ciuffi, Manuel Llano, Eric Poeschla, Christian Hoffmann, Jeremy Leipzig, Paul Shinn, Joseph R Ecker, Frederic Bushman. Nat Med 11(12):1287-9 [http://www.ebi.ac.uk/arrayexpress/browse.html?keywords=E-GEOD-3485&species=&array=&exptype[]=&exptype[]=&pagesize=25&sortby=releasedate&sortorder=descending&expandefo=on Array Express Link] |
[1] Reference one Geo | [1] Reference one Geo | ||
[1] Reference one Geo | [1] Reference one Geo |
Revision as of 07:16, 27 September 2010
The cell line used in this project is the human embryonic kidney cell line 293T .
The NCBI GEO and ArrayExpress databases were extensively searched for environmental conditions leading to apoptosis in 293T cells and genes differentially expressed under these conditions. The following data was obtained:
In order to understand gene regulation of apoptosis regulated genes the Transcriptional Regulatory Element Database (TRED) was used to extract known promoters and the STRING database for known and predicted protein-protein interactions. The lists of all known human transcription factors were downloaded from here and here.
Cell Line
Databases Search
Environmental Condition (EV)
Number of genes differentially expressed
Reference
Conduritol B Epoxide treatment
57
[1]
Gammaherpesvirus
103
[2]
HIV integration
1
[3]
HLTV-1 p30
2291
[4]
Hypoxia
2
[5]
RCAS-beta-cateinS37A
55
[6]
[1] Campeau PM, Rafei M, Boivin MN, Sun Y et al. Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome. Blood 2009 Oct 8;114(15):3181-90. GEO Link
[2] Gene Expression and Transcription Factor Profiling Reveal Inhibition of Transcription Factor cAMP-response Element-binding Protein by {gamma}-Herpesvirus Replication and Transcription Activator. Brown HJ, Peng L, Harada JN, Walker JR, Cole S, Lin SF, Zack JA, Chanda SK, Sun R. J Biol Chem 285(33):25139-53 [=&exptype[]=&pagesize=25&sortby=releasedate&sortorder=descending&expandefo=on Array Express Link]
[3] A role for LEDGF/p75 in targeting HIV DNA integration. Angela Ciuffi, Manuel Llano, Eric Poeschla, Christian Hoffmann, Jeremy Leipzig, Paul Shinn, Joseph R Ecker, Frederic Bushman. Nat Med 11(12):1287-9 [=&exptype[]=&pagesize=25&sortby=releasedate&sortorder=descending&expandefo=on Array Express Link]
[1] Reference one Geo
[1] Reference one Geo
[1] Reference one Geo