Team:Groningen/Home

From 2010.igem.org

(Difference between revisions)
Line 3: Line 3:
<div style="height: 1330px">
<div style="height: 1330px">
<div id="slider" style="margin-left: 10px; height: 343px;">
<div id="slider" style="margin-left: 10px; height: 343px;">
-
<img src="http://2010.igem.org/wiki/images/d/dd/Groningen-Reel-Stage1.jpg" alt="" title="Biofilm formation" />
+
<img src="http://2010.igem.org/wiki/images/d/dd/Groningen-Reel-Stage1.jpg" alt="" title="#biofilm-caption" />
-
<img src="http://2010.igem.org/wiki/images/d/d3/Groningen-Reel-Stage2.jpg" alt="" title="Chaplin expression" />
+
<img src="http://2010.igem.org/wiki/images/d/d3/Groningen-Reel-Stage2.jpg" alt="" title="#chaplin-caption" />
-
<img src="http://2010.igem.org/wiki/images/6/6f/Groningen-Reel-Stage3.jpg" alt="" title="Controlled cell death" />
+
<img src="http://2010.igem.org/wiki/images/6/6f/Groningen-Reel-Stage3.jpg" alt="" title="#killswitch-caption" />
</div>
</div>
<script type="text/javascript">
<script type="text/javascript">
Line 12: Line 12:
</script>
</script>
-
<div style="text-align: justify; margin-left: 10px">  
+
<div id="biofilm-caption" class="nivo-html-caption">
 +
  A self assembling bio-based coating is form, a </html>[http://2010.igem.org/Team:Groningen#/biofilm rigid biofilm]<html>.
 +
</div>
 +
<div id="chaplin-caption" class="nivo-html-caption">
 +
    </html>[http://2010.igem.org/Team:Groningen#/expression Expression]<html> of hydrophobic proteins called </html>[http://2010.igem.org/Team:Groningen#/hydrophobins chaplins]<html> is induced by the biofilm causing strong surface hydrophobicity.
 +
</div>
 +
<div id="killswitch-caption" class="nivo-html-caption">
 +
    The strongly hydrophobic biofilm will die off by a </html>[http://2010.igem.org/Team:Groningen#/killswitch_model killswitch]<html>, leaving a nice hydrophobic biological coating.
 +
</div>
 +
 
 +
 
 +
<div margin-left: 10px">  
</html>
</html>
===Self assembling hydrophobic biofilm===
===Self assembling hydrophobic biofilm===

Revision as of 19:04, 27 October 2010

A self assembling bio-based coating is form, a rigid biofilm.
Expression of hydrophobic proteins called chaplins is induced by the biofilm causing strong surface hydrophobicity.
The strongly hydrophobic biofilm will die off by a killswitch, leaving a nice hydrophobic biological coating.

Self assembling hydrophobic biofilm

Surface hydrophobicity is a very useful property and is used in many applications ranging from raincoats, antifouling coatings to applications in the field of medical sciences.

The idea is to engineer a bacterium that once applied to a surface starts forming a fast growing rigid biofilm. The formation will trigger the expression of hydrophobic proteins called chaplins. These hydrophobic proteins will be incorporated in the biofilm, causing strong hydrophobic surface activity. The result is a hydrophobic biobased surface coating. During the project we've created numerous Biobrick parts to achieve this.

Team
This year a team of young inspired undergraduates from the University of Groningen participated in the amazing challenge of iGEM. A multi-disciplinary team of Molecular Biologists, Chemists, Computer Scientists, Journalists and others spend the summer creating a wonderful project in the emerging field of synthetic biology
Modeling
Using computer models we worked on the frontiers of knowledge. Gene expression was simulated and a simple explanation for cell differentiation was proposed. Also aiding in ethics and practical feasibility a kill switch system was studied. Finally a new standard was proposed for characterizing Biobrick parts so future can be streamlined.
Human Practices
Because we believe that synthetic biology can better the lives of people and ensure long term prosperity for all humans we spend time educating high school students. But not all is perfect so risks were assessed and we philosophized on the ethical aspects of synthetic biology.


Our sponsors

Sigma Aldrich DSM NGI GBB Kluyver Center Bioké Stichting biotechnology Nederland (SBN) 101 promotions Center for Synthetic Biology