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From 2010.igem.org

Contents 1 ODE models of the chemotaxis pathway 1.1 Spiro (1997) 1.2 Mello (2003) 1.3 Rao et al. (2004) 1.4 Barkai & Leibler (1997)

ODE models of the chemotaxis pathway

Spiro (1997)

This model basically predicts that for all Che proteins (CheR, B, Y and Z) would make a good light input. For CheR and CheY the concentration of CheYp drops more than Delta (initial value - Threshold), for CheB and CheZ it increases more than Delta. For all Che proteins the concentrations stay like forever below/above the Threshold, until we deactivate them with far-red light. The best results was obtained for assuming a high ligand concentration (saturation, so that the methylation level of the receptors is high). For CheY and CheZ the reaction times were (as expected), much faster than for CheB and CheR. However, for these proteins the reaction times were still fast enough.

Mello (2003)

This model is already implemented compatible to the Spiro1997 model, but not yet documented.

Rao et al. (2004)

This model predicts quite a similar behavior of the Che proteins, as demonstrated by the previous model. A notable difference is that the response of CheYp level to the change of the level of the other Che proteins is robust to the fluctuations of the ligand (attractant) concentration. In the previous model (Spiro), the most desirable results were obtained only for higher concentrations of the ligand.

A detailed analysis of the simulation results obtained from this model can be found here.

Barkai & Leibler (1997)

The model is implemented, but not yet documented.