Team:Bielefeld-Germany/Project/Outlook

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Contents

Outlook

The techniques’ potential

Acetosyringone


see pubchem datasheet

In our project we modulated the virA-gene from ’’A. tumefaciens’’, which is encoding a receptor for the plant-hormone acetosyringone, via error prone PCR. Slight mutations may alter the receptors conformation or its binding site. Both of these can cause shifts in specificity and sensitivity. This way we created a new receptor, which is capable of sensing capsaicin. The chemical formulas of capsaicin and acetosyringone are quite similar and there are other molecules of interest, that have some of the necessary properties, too. Thus, we suggest that it is possible to modulate VirA receptors in order to make them sense a variety of highly relevant compounds.

In other words, there are other candidates our sensing system may be applied to. All of them have similiar molecular structures as the vir-systems natural inducor acetosyringone. In the following we will present some of the most relevant compounds other than capsaicin, that may be upcoming targets of our research.

Dopamine

Following some text ´bout it

3-Methoxytyramine

3-Methoxytyramine


see pubchem datasheet
Following some text ´bout it

Homovanillic acid

Homovanillic acid


see pubchem datasheet
Following some text ´bout it

Vanilmandelic Acid

Vanilmandelic Acid


see pubchem datasheet
Following some text ´bout it