Team:Bielefeld-Germany/Project/Outlook

From 2010.igem.org

Revision as of 12:26, 23 October 2010 by Nkessler (Talk | contribs)

{{{1}}}

Contents

Outlook

The techniques’ potential

In our project we modulated the virA-gene from ’’A. tumefaciens’’, which is encoding a receptor for the plant-hormone acetosyringone, via error prone PCR. Slight mutations may alter the receptors conformation or its binding site. Both of these can cause shifts in specificity and sensitivity. This way we created a new receptor, which is capable of sensing capsaicin. The chemical formulas of capsaicin and acetosyringone are quite similar and there are other molecules of interest, that have some of the necessary properties, too. Thus, we suggest that it is possible to modulate VirA receptors in order to make them sense a variety of highly relevant compounds.

A whole lot of candidates

[|200px|thumb|left|Acetosyringone] [[1]] As stated, there are other candidates our sensing system may be applied to. All of them have similiar molecular structures as the vir-systems natural inducor acetosyringone. In the following we will present some of the most relevant compounds other than capsaicin, that may be upcoming targets of our research.

Dopamine

[[2]] [[3]] Following some text ´bout it

3-Methoxytyramine

[[4]] Following some text ´bout it

Homovanillic acid

[[5]] [[6]] Following some text ´bout it

Vanilmandelic Acid

[[7]] [[8]] Following some text ´bout it